Podophyllum is a plant. The root and underground stem (rhizome) are used to make medicine.

Podophyllum is poisonous when taken by mouth. Despite this, some people take it orally for yellowed skin (jaundice), liver ailments, fever, syphilis, hearing loss, and cancer. Podophyllum is also used to empty the bowels, kill parasitic worms in the intestine, and counteract snakebites. Some women take it to cause an abortion.