96.20

Content Details
Information on this page was last modified on : 2019/08/14 3:42:21 AM
, This drug requires a valid prescription from PMDC registered health practitioner.
Manufactured by
Contains

218-TRIAL-Abbocin Injection contains Tobramycin, Inj | belongs to Aminoglycoside

Product SKUpg_75_104
Belongs to Category,
Drug Strength
Pack size

Side effects

Major & minor side effects for 218-TRIAL-Abbocin Injection 20 mg 1 Vial

  • Neuromuscular blockade severe
  • Hearing loss
  • Ringing or buzzing in the ears
  • Headache
  • Nosebleed severe
  • Difficulty in breathing severe
  • Hoarseness of voice severe
  • Unusual tiredness and weakness severe
  • Fever severe

Uses of 218-TRIAL-Abbocin Injection 20 mg 1 Vial

What is it prescribed for?

  • Bacterial infections

    218-TRIAL-Abbocin Injection 20 mg 1 Vial injection is used in the treatment of bacterial infections of the abdomen, brain and spinal cord, heart, bones, and joints.

  • Cystic fibrosis

    218-TRIAL-Abbocin Injection 20 mg 1 Vial is used as an injection and an intranasal agent for the treatment of cystic fibrosis. The symptoms of this disease are clubbing of fingers, breathing difficulty, poor growth, frequent chest infection, poor weight gain, and coagulation disorder in a few patients, and infertility in males.

Concerns

Frequently asked questions

  • Onset of action

    The amount of time required for this medicine to show its action is not clinically established.

  • Duration of Effect

    The effect of this medicine lasts for an average duration of 6 to 24 hours depending on the route of administration.

  • Safe with Alchohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    No habit forming tendencies were reported.

  • Usage in pregnancy?

    This medicine is not recommended for use in pregnant women.

  • Usage while breast-feeding?

    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Eye drops or ear drops of this medicine may be used since they present little or no risk to the nursing infant. Discuss all the risks and benefits with your doctor before taking this medicine.

When not to use?

  • Allergy

    This medicine is not recommended for use in patients with a known allergy to 218-TRIAL-Abbocin Injection 20 mg 1 Vial or other aminoglycosides.

Warnings

Warnings for special population
  • Pregnancy

    This medicine is not recommended for use in pregnant women.

  • Breast-feeding

    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Eye drops or ear drops of this medicine may be used since they present little or no risk to the nursing infant. Discuss all the risks and benefits with your doctor before taking this medicine.

Warnings

Warnings for special population
  • Drug resistance

    Use of 218-TRIAL-Abbocin Injection 20 mg 1 Vial without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.

  • Neuromuscular disorders

    218-TRIAL-Abbocin Injection 20 mg 1 Vial is not recommended for use in patients with existing neuromuscular diseases like Parkinsonism or Myasthenia gravis since it may worsen the condition of the patient.

  • Impaired kidney function

    218-TRIAL-Abbocin Injection 20 mg 1 Vial may increase the risk of kidney injury, especially when high doses are used for a prolonged period of time. Suitable dose adjustments should be made based on the creatinine clearance (CrCl).

Dosage

  • Missed Dose

    If a dose is missed, take the dose as soon as you remember it. If it is almost the time for the next dose, skip the missed dose and take the next dose. Do not double the dose to make up for the missed one.

  • Overdose

    Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions

Interaction with Medicines
  • Colistin severe
  • Diuretics severe
  • Live cholera vaccine severe
  • Neuromuscular blockers severe
Disease interactions
  • severe

    Consume an adequate amount of water to prevent kidney injury and hearing problems. Fluid status should be monitored closely, especially in patients with severe diarrhea and vomiting who are receiving 218-TRIAL-Abbocin Injection 20 mg 1 Vial. Frequent monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments should be made based on the clinical condition of the patient.

General Instructions

Strictly follow the instructions on the label and take 218-TRIAL-Abbocin Injection 20 mg 1 Vial only as directed. Drink plenty of water to avoid kidney damage. Do not take more than what is prescribed or share this medication with other people. It is advised that you inform the doctor about all the medicines or herbal products that you are using and about all your medical conditions before taking this medicine.

Other details

  • Usage does not depend on food timings
  • To be taken as instructed by doctor
  • Does not cause sleepiness

How it works

218-TRIAL-Abbocin Injection 20 mg 1 Vial is a broad-spectrum antibiotic which kills the bacteria by blocking the production of certain proteins that are required for their growth.

References

How to use 218-TRIAL-Abbocin Injection 20 mg 1 Vial

IV: Infuse over 30-60 min. Give penicillins or cephalosporins at least 1 hour apart from tobramycin.
Reconstitution: Standard diluent: Dose/100 mL NS; minimum volume: 50 mL NS
Compatibility: Stable in dextran 40 10% in dextrose, D5NS, D5W, D10W, mannitol 20%, LR, NS. Don’t mix tobramycin in same solution with parenteral aminoglycosides or beta lactam antibiotics because mutual inactivation may occur.
Y-site administration:
Drug to Drug IV Compatibility: Acyclovir, amikacin, amiodarone, aztreonam, bumetanide, calcium gluconate, ciprofloxacin, cisatracurium, diltiazem, diphenhydramine, dobutamine, dopamine, enalapril, epinephrine, esmolol, famotidine, fentanyl, fluconazole, furosemide, gentamicin, hydromorphone, imipenem, labetalol, levofloxacin, linezolid, lorazepam, magnesium sulphate, methylprednisolone, metoclopramide, midazolam, milrinone, nitroglycerin, nitroprusside, norepinephrine, ondansetron, phenylephrine, vancomycin, vasopressin.
Drug to Drug IV Incompatibility: Allopurinol, amphotericin B cholesteryl sulphate complex, azithromycin, cefoperazone, ceftriaxone, dexamethasone, heparin, hetastarch, indomethacin, lansoprazole, piperacillin/tazobactam, propofol, sargramostim.
In syringe: Incompatible with cefamandole, clindamycin, heparin.
When admixed: Incompatible with cefamandole, cefepime, cefotaxime, cefotetan, floxacillin, heparin, penicillins.
Stability: Stable at room temperature as the dry powder. Reconstituted solution remains stable for 24 hours at room temperature and 96 hours when refrigerated.

what are the adverse effects of 218-TRIAL-Abbocin Injection 20 mg 1 Vial

Voice alteration, cough, dyspnoea, nausea. Rarely, bronchospasm, tinnitus, dysphonia, lung disorders, laryngitis, sputum discolouration, GI upset, rhinitis, malaise, myalgia, hearing loss, dysgeusia, rash, haemoptysis, epistaxis, chest pain, pyrexia, nasal congestion.

What is the dose of 218-TRIAL-Abbocin Injection 20 mg 1 Vial

Adults: 3-5 mg/kg daily in three or four divided doses by IM/IV inj or infusion. Children: Neonates, up to 4 mg/kg daily in two equal doses; others, 6-7.5 mg/kg daily in 3 or 4 divided doses.
Bone Infection: IM/IV: Adults: 3 mg/kg/day given every 8 hr. Max: 5 mg/kg/day in 3-4 doses. Reduce to 3 mg/kg/day as soon as clinically indicated. Children: gt;1 wk: 2-2.5 mg/kg every 8 hr or 1.5-1.89 mg/kg every 6 hr. 1 wk or less: Up to 2 mg/kg every 12 hr.
Lower Respiratory Infection, Meningitis & Septicaemia: IV: Adults: 3 mg/kg/day given every 8 hr. Max: 5 mg/kg/day in 3-4 doses. Reduce to 3 mg/kg/day as soon as clinically indicated. Children: gt;1 wk: 2-2.5 mg/kg every 8 hr or 1.5-1.89 mg/kg every 6 hr. lt;1 wk: Up to 2 mg/kg every 12 hr.

One of the following licensed pharmacy from the nearest location will deliver 218-TRIAL-Abbocin Injection 20 mg 1 Vial. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts the your request based on valid prescription and availability.

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