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Content Details
Information on this page was last modified on : 2019/08/10 5:44:54 PM
, This drug requires a valid prescription from PMDC registered health practitioner.
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Contains

Abex Injection IV contains Ceftriaxone | belongs to Cephalosporin

Product SKUpg_82_114
Belongs to Category,
Drug Strength
Pack size

Side effects

Major & minor side effects for Abex Injection IV 1 gm 1 Vial

  • Black or tarry stools Severe
  • Chest pain Severe
  • Fever
  • Difficulty or painful urination
  • Sore throat
  • Diarrhea
  • Abdominal pain
  • Dizziness
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Acid or sour stomach
  • Change in taste
  • Excessive air or gas in stomach

Uses of Abex Injection IV 1 gm 1 Vial

What is it prescribed for?

  • Bacterial Meningitis

    Abex Injection IV 1 gm 1 Vial is used in the treatment of meningitis, which is an inflammation of the protective membranes that surround the brain and spinal cord. This infection may be caused by Streptococcus pneumoniae or Neisseria meningitidis.

  • Bacterial Septicemia

    Abex Injection IV 1 gm 1 Vial is used in the treatment of septicemia which is an infection of the blood caused by Staphylococci and Streptococcus pyogenes.

  • Gonococcal Infection

    Abex Injection IV 1 gm 1 Vial is used in the treatment of gonococcal infection which is a sexually transmitted bacterial infection caused by Neisseria gonorrhoeae.

  • Urinary Tract Infection

    Abex Injection IV 1 gm 1 Vial is used in the treatment of infections of the urinary tract caused by E.coli, Pseudomonas aeruginosa, Enterococci and Klebsiella pneumoniae.

  • Pneumonia

    Abex Injection IV 1 gm 1 Vial is used in the treatment of community-acquired pneumonia which is a common type of lung infection caused by Streptococcus pneumoniae and Haemophilus influenzae.

  • Bone and joint infections

    Abex Injection IV 1 gm 1 Vial is used in the treatment of bone and joint infections such as septic arthritis and osteomyelitis caused by Staphylococci and Streptococci species.

  • Skin and structure Infection

    Abex Injection IV 1 gm 1 Vial is used in the treatment of Skin and structure infections such as cellulitis, wound infection and cutaneous abscesses caused by Streptococcus pyogenes and Staphylococcus aureus.

Concerns

Frequently asked questions

  • Onset of action

    The effect of this medicine occurs rapidly after intravenous and intramuscular routes of administration of the dose.

  • Duration of Effect

    The effect of this medicine lasts for an average duration of 24 hours.

  • Safe with Alchohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    No habit forming tendency has been reported.

  • Usage in pregnancy?

    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.

  • Usage while breast-feeding?

    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.

When not to use?

  • Allergy

    This medicine is not recommended for use in patients with a known allergy to Abex Injection IV 1 gm 1 Vial or any other Beta-lactam antibiotics such as penicillins or cephalosporins.

  • Lidocaine

    Abex Injection IV 1 gm 1 Vial is contraindicated for use if Lidocaine is used as a solvent for intravenous injection. Lidocaine can be used as a solvent for the intramuscular route of injection for this medicine, despite contraindications.

  • Calcium-containing products

    Abex Injection IV 1 gm 1 Vial is contraindicated in neonates who are on calcium-containing intravenous solutions or infusions such as parenteral nutrition because of the risk of precipitation of Abex Injection IV 1 gm 1 Vial and calcium.

Warnings

Warnings for special population
  • Pregnancy

    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.

  • Breast-feeding

    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.

Warnings

Warnings for special population
  • Allergy

    This medicine is not recommended for use in patients with a known history of allergy to Abex Injection IV 1 gm 1 Vial or Beta-lactam Antibiotics such as penicillins and cephalosporins.

  • Hemolytic anemia

    An immune mediated hemolytic anemia has been reported in patients receiving Abex Injection IV 1 gm 1 Vial and other cephalosporins. Report any unusual symptoms to the doctor immediately. Your doctor may advise you to discontinue the medicine if you develop hemolytic anemia until the exact cause is determined.

  • Prothrombin time

    Alterations in prothrombin time (a test used to check for bleeding problems) have been reported in patients receiving Abex Injection IV 1 gm 1 Vial . Regular monitoring of prothrombin time may be necessary for some patients. Replacement with a suitable alternative may be required in some cases based on the clinical condition.

  • Drug-resistance

    Usage of Abex Injection IV 1 gm 1 Vial without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.

  • Patients with impaired kidney or liver function

    This medicine should be used with caution in patients with kidney or liver diseases due to the increased risk of severe adverse effects. The dose of this medicine should not exceed 2 g/day for such patients.

  • Clostridium difficile-associated Diarrhea

    This medicine is not recommended for use if you experience severe diarrhea after receiving Abex Injection IV 1 gm 1 Vial . Antibiotic therapy may cause an imbalance in the normal microbial flora in the large intestine; this may promote the growth of bacteria called Clostridium difficile, leading to severe diarrhea. Your doctor may prescribe a safer alternative based on your clinical condition.

  • Use in neonates

    is not recommended in patients less than 28 days of age.

Dosage

  • Missed Dose

    Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of missing a dose is very low.

  • Overdose

    Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.

Interactions

Interaction with Medicines
  • Amikacin Moderate
  • Ethinyl Estradiol Moderate
  • Cholera Vaccine Severe
  • Cyclosporine Moderate
Disease interactions
  • Moderate

    This medicine may cause diarrhea, abdominal pain and blood in stools in some cases. This risk is especially higher in patients with a history of gastrointestinal diseases. Drink an adequate amount of water to prevent dehydration. Report any such symptoms to the doctor immediately. Replacement with a suitable alternative may be required based on the clinical condition.

  • Moderate

    This medicine should be used with caution in patients with a history of seizure disorder or a family history of seizures since it may worsen the patient's condition. Report any unusual symptoms to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

General Instructions

This medicine is usually administered in the hospital by a qualified healthcare professional. Carefully follow all the instructions given by your doctor. Report any unusual symptoms or side effects to the doctor immediately. Report any allergies to antibiotics to the doctor prior to using this medicine.

Other details

  • Usage does not depend on food timings
  • To be taken as instructed by doctor
  • May cause sleepiness

How it works

Abex Injection IV 1 gm 1 Vial works by interfering with certain processes that help the bacteria to grow and increase in number.

References

How to use Abex Injection IV 1 gm 1 Vial

Ceftriaxone may be administered by IV intermittent infusion over 10-30 min; final concentration for IV administration should not exceed 40 mg/mL. The drug has also been administered by direct IV push over 2-4 min. Inject deep IM into large muscle mass.
IM Injection: 250 mg/500 mg/1000 mg VIAL: To make concentration of 250 mg/mL add Water for Injection 0.9 mL in 250 mg vial; 1.8 mL in 500 mg vial; 3.6 mL in 1000 mg vial.
IV: 250 mg/500 mg/1000 mg VIAL: To make concentration of 100 mg/mL add Water for Injection 2.4 mL in 250 mg vial; 4.8 mL in 500 mg vial; 9.6 mL in 1000 mg vial.
Compatibility: Stable in D5W with KCl 10 mEq, D5W, D10W, NS, mannitol 5%, mannitol 10%, sodium bicarbonate 5%, bacteriostatic water, SWFI.
Y-site administration:
Drug to Drug IV Compatibility: Acyclovir, amikacin, amiodarone, aztreonam, bumetanide, cephazolin, cisatracurium, dexamethasone, diltiazem, dopamine, enalapril, epinephrine, esmolol, fentanyl, furosemide, heparin, hydrocortisone, hydromorphone, insulin regular, lansoprazole, levofloxacin, lorazepam, methylprednisolone, metoclopramide, metronidazole, midazolam, morphine, nitroglycerin, nitroprusside, norepinephrine, pantoprazole, phenylephrine, propofol, vasopressin.
Drug to Drug IV Incompatibility: Alatrofloxacin, amphotericin B cholesteryl sulphate complex, amsacrine, azithromycin, calcium gluconate, diphenhydramine, dobutamine, filgrastim, fluconazole, imipenem, labetalol, magnesium sulphate, pentamidine, tobramycin, vinorelbine.
When admixed: Incompatible with aminophylline, clindamycin, linezolid, theophylline.
Stability: For IV infusion in NS or D5W, solution is stable for 24 hours at room temperature or 3 days when refrigerated.

what are the adverse effects of Abex Injection IV 1 gm 1 Vial

GI upset, skin reactions, blood dyscrasias. Rarely pseudomembranous colitis, raised liver enzymes, glucosuria, oliguria, haematuria, bronchospasm, phlebitis at inj site, urinary and biliary precipitates, pancreatitis, nephrolithiasis, haemolytic anaemia, positive Coombs test.

What is the dose of Abex Injection IV 1 gm 1 Vial

Adults: Usually 1 gm daily by deep IM, slow IV inj over at least 2-4 min, or IV infusion. Severe infections, 2-4 gm as a single dose every 24 hr. Children: Usually 20-50 mg/kg once daily by IM inj, slow IV inj over at least 2-4 min, or IV infusion. Severe infections, up to max 80 mg/kg daily (max 50 mg/kg in neonates). Doses over 50 mg/kg to be given by slow IV infusion over at least 30 min.
Peri-op prophylaxis: Adults: 1 gm as single IM or slow IV dose.
Colorectal surgery: Adults: 2 gm by IM, slow IV inj or infusion with anaerobic antibacterial.
Lower Respiratory Infection: Adults: IM/IV: Usual: 1-2 gm once daily (or in equally two divided doses). Max: 4 gm/day.
Otitis Media: Children: 50 mg/kg IM single dose. Max: 1 gm/dose.
Bone Infection: Adults: IM/IV: Usual: 1-2 gm once daily (or in equally divided two doses). Max: 4 gm/day.
Meningitis: IV: Adults: 1-2 gm once daily (or in equally divided two doses). Max: 4 gm/day. Children: Initial of 100 mg/kg (not to exceed 4 gm), then 100 mg/kg once daily or (in equally divided two doses) for 7-14 days. Max: 4 gm/day.
Septicaemia: IV: Adults: 1-2 gm once daily (or in equally divided two doses). Max: 4 gm/day. Children: 50-75 mg/kg in divided doses every 12 hr. Max: 2 gm/day.
Urinary Tract Infection: Adults: IM/IV: 1-2 gm once daily (or in equally divided two doses). Max: 4 gm/day.
Gonorrhoea: Single dose of 250 mg by IM inj.

One of the following licensed pharmacy from the nearest location will deliver Abex Injection IV 1 gm 1 Vial. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts the your request based on valid prescription and availability.

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