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Information on this page was last modified on : 2020/06/29 3:04:30 PM

Absolute tablet 10 mg 10's

Absolute tablet contains Olanzapine | belongs to Thienobenzodiazepine

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How it works

Combination of Dopamine and Serotonin type 2 receptor site antagonism.

Side effects

Major & minor side effects for Absolute tablet 10 mg 10’s

  • Orthostatic Hypotension
  • Weight gain severe
  • Headache severe
  • Sleepiness
  • Increase in body fat and cholesterol
  • Dizziness
  • Uncontrolled muscle movements
  • Chest pain severe
  • Dry mouth
  • Running nose and cough
  • Loss of libido
  • Change in personality severe

Uses of Absolute tablet 10 mg 10’s

What is it prescribed for?

  • Schizophrenia

    [post-title] is used for the treatment of symptoms of Schizophrenia.

  • Bipolar Mania

    [post-title] nzapine is used for acute relief from Manic episodes associated with Bipolar Disorder.

  • Depression

    [post-title] is used in combination with other drugs to treat depression associated with Bipolar Disorder.

  • Agitation

    [post-title] is used to treat moderate to severe agitation associated with Schizophrenia and Bipolar Disorder.

Concerns

Frequently asked questions

  • Onset of action

    The peak effect of [post-title] (which is the main constituent of [post-title]) can be observed after 5-8 hours of oral administration. Upon intramuscular injection, the effect can be observed after 15-45 minutes. The extended release forms tend to take longer than the other forms.

  • Duration of Effect

    The effect of this medication is cumulative and the oral form stays in the body for 21 to 54 hours while the extended release form stays for 30 days.

  • Safe with Alchohol?

    Use of Alcohol is not recommended while you are taking [post-title] Any activity requiring high level of mental alertness should be avoided and symptoms like mental confusion, drowsiness should be reported to the doctor immediately.

  • Is it habit forming?

    No habit forming tendencies were reported. However, patients with a history of drug abuse should be monitored closely for misuse.

  • Usage in pregnancy?

    Use of this medicine is not recommended during pregnancy as it can cause developmental defects in the newborn. Since there is a lack of conclusive evidence from human studies, consult your doctor if you are pregnant. All the potential benefits and risks should be considered before taking this medicine.

  • Usage while breast-feeding?

    Use of this medicine is not recommended for breastfeeding mothers as it is excreted via breast milk. Though the effects are not ascertained, it is recommended to consult your doctor before taking the medicine. Close monitoring of symptoms in infants might be required in some cases.

Warnings

Warnings for special population
  • Pregnancy

    Use of this medicine is not recommended during pregnancy as it can cause developmental defects in the newborn. Since there is a lack of conclusive evidence from human studies, consult your doctor if you are pregnant. All the potential benefits and risks should be considered before taking this medicine.

  • Breast-feeding

    Use of this medicine is not recommended for breastfeeding mothers as it is excreted via breast milk. Though the effects are not ascertained, it is recommended to consult your doctor before taking the medicine. Close monitoring of symptoms in infants might be required in some cases.

Warnings

Warnings for special population
  • Hyperglycemia

    Use of [post-title] may increase the risk of high blood sugar levels in patients who are diabetic or are exposed to the risk factors. Severe adverse reactions leading to Ketoacidosis, Hyperosmolar coma and even death have been reported in some rare cases. It is advised to constantly monitor the blood sugar levels while taking this medicine.

  • Muscular Disorders

    [post-title] is likely to cause problems with movements and muscular disorders. Any incidence of ticks or uncontrolled muscle movements, fever, dizziness and weakness in muscles should be reported to the doctor immediately. Special caution should be exercised in elderly patients and women while prescribing this medicine.

  • Suicidal Tendencies

    [post-title] is likely to cause suicidal thoughts in patients suffering from Schizophrenia and Bipolar Disorders. Close monitoring of high-risk patients is a must while [post-title] is administered.

  • Dyslipidemia

    [post-title] is likely to cause changes in the levels of cholesterol and fats in the body. The fat and cholesterol levels are to be monitored to prevent and manage the after-effects.

  • Weight gain

    [post-title] is likely to cause a gain in weight and hence periodic monitoring is required especially in patients who are obese.

  • Orthostatic hypotension

    [post-title] is likely to position based decrease in blood pressure especially during the start of therapy. It should be given very carefully to patients who have an active disease of the heart and valves. Any condition leading to a decrease in blood pressure should be given consideration while deciding the dose.

  • Low Blood Count

    [post-title] is likely to cause a decrease in blood cell count including white blood cells and overall count. It should be administered with caution in patients who have an active blood condition. Dose adjustments and clinical monitoring of blood cell levels might be required in such cases.

  • Cognitive and motor impairment

    [post-title] is likely to cause changes in perception, thoughts and might affect brain centrally controlled movements of muscles. Proper dosing and safety monitoring become a necessity especially if the patient has some form of active mental illness.

  • Alzheimer's Disease

    [post-title] is not recommended for use in patients suffering from Alzhiemer's Disease as the risks of life-threatening side effects rise substantially.

Dosage

  • Missed Dose

    Contact your doctor immediately if you have missed a scheduled dose. One should avoid taking the missed dose without consulting your doctor.

  • Overdose

    Contact a doctor immediately if an overdose of this medicine is suspected. An overdose with [post-title] requires immediate supportive measures like airway clearance, gastric lavage etc. Since treatment is symptom based, it is advised that the patient is kept under supervision in a medical facility with regular monitoring.

Interactions

Interaction with Medicines
  • Acarbose moderate
  • Amlodipine moderate
  • Cetirizine moderate
  • Diazepam severe
  • Tramadol severe
  • Atropine moderate
Disease interactions
  • severe

    Use of [post-title] is not recommended in treating Psychosis related to Dementia especially in the elderly. Any dementia-related incidence should be reported to the Doctor.

  • severe

    Use of [post-title] is not recommended if the patient is in a coma and has severe Central Nervous System Depression. Symptoms like decreased rate of breathing and decreased heart beat rate should be reported immediately.

  • severe

    Use of [post-title] is not recommended if the patient suffers from Neuroleptic malignant syndrome. Introduction or reintroduction of this medicine should be done with caution in patients having a known history of this syndrome.

  • severe

    Use of [post-title] is not recommended in patients with active Tardive Dyskinesia. Women and elderly patients are more likely to develop or exacerbate the symptoms on prolonged consumption of this medicine. The medicine should be withdrawn if symptoms like uncontrolled movements of tongue, mouth, lips, jaws etc are experienced during therapy with this medicine. Suitable alternatives can be prescribed in such cases.

  • moderate

    Use of [post-title] is not recommended in patients having a known history of seizure attacks. The medicine should be administered with extreme caution in such cases.

  • moderate

    [post-title] should be administered with caution in patients having Diabetes or are exposed to the risk factors. Proper monitoring of blood glucose levels is necessary in such cases.

Lab interactions

General Instructions

[post-title] should be used as directed by the doctor. The dosage strengths, timings, and other aspects are specific for you and should be followed strictly for better effect. Read the instruction mentioned on the label carefully and follow them while taking the medicine. It is advised to take an injectable form of this medicine in the presence of a trained healthcare professional only.

Other details

  • Food timings: Information not available
  • Administration time: Information not available
  • Sleep inducing: Information not available

References

How to use Absolute tablet 10 mg 10’s

Short acting IM Inj: For IM use only. Inject slowly deep into muscle. Extended release IM Inj: For IM gluteal injection only after needle insertion in to muscle, aspirate to verify that no blood appears. Do no massage injection site.
Stability: Injection extended release: Store at 20°C-25°C; excursions permitted to 15°C-30°C. Dilute as directed to final concentration of 150 mg/mL following the reconstitution, it may be stored at room temperature and use within 24 hours. Shake well to resuspend prior to administration. Injection short acting: Store at 20°C-25°C; excursions permitted to 15°C-30°C. Do not freeze. Protect from light. Reconstitute 10 mg vial with 2.1 mL SWFI. Resulting solution is 5 mg/mL. Use within 1 hour.

UNLICENSED USE
Children: When one or more factors are present that might result in slower metabolism (e.g. female gender, non-smoker) consider lower initial dose and more gradual dose increase.
Schizophrenia, combination therapy for mania: 12-18 yr, initially 5-10 mg daily adjusted to usual range of 5-20 mg daily; doses greater than 10 mg daily only after reassessment, max 20 mg daily.
Monotherapy for mania: 12-18 yr, 15 mg daily adjusted to usual range of 5-20 mg daily, doses greater than 15 mg only after reassessment, max 20 mg daily.

what are the adverse effects of Absolute tablet 10 mg 10’s

Somnolence, weight gain, increased appetite, dizziness, peripheral oedema, orthostatic hypotension, anticholinergic effects raised ALT/AST.

What is the dose of Absolute tablet 10 mg 10’s

Adults: ORAL: Schizophrenia: Usual: 5-10 mg daily. Titrate: Adjust weekly by 5 mg/day. Max: 20 mg/day.
Bipolar Disorder: Acute Manic & Mixed Episodes: Monotherapy: Initial: 10-15 mg daily. Combination therapy with lithium or valproate: Initial: 10 mg daily. Range: 5-20 mg/day. Max: 20 mg/day. Titrate: Adjust by 5 mg/day. Max: 20 mg/day. Maintenance monotherapy: 5-20 mg/day.
Children: Not recommended.
INJECTION: Adults: By deep IM injection into the gluteal muscle. Patients taking oral olanzapine 10 mg daily, initially 210 mg every 2 wk or 405 mg every 4 wk, then maintenance dose after 2 mth treatment, 150 mg every 2 wk or 300 mg every 4 wk; Patients taking oral olanzapine 15 mg daily, initially 300 mg every 2 wk, then maintenance dose after 2 mth treatment, 210 mg every 2 wk or 405 mg every 4 wk; Patients taking oral olanzapine 20 mg daily, initially 300 mg every 2 wk, then maintenance dose after 2 mth treatment 300 mg every 2 wk; dose adjusted according to response; Max 300 mg every 2 wk.
Children: Not recommended.

One of the following licensed pharmacy from the nearest location will deliver Absolute tablet 10 mg 10’s. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts the your request based on valid prescription and availability.

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