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AFRACIN 300mg Tablet 100s

Rifampicin:300mg + Isoniazid:150mg | Anti-tuberculosis drugs

Alternate brands of AFRACIN 300mg Tablet 100s

Brand Name Price Savings
RIMAZID 300mg Tablet 3x10s  139.00 You can save 284.57
RIFAN 300mg Tablet 30s  559.00 You will pay -135.43 more
RIFASAL ISO 300mg Capsule 3x10s  0.00 You can save 423.57
RIFA+FORT 300mg Tablet 100s  462.00 You will pay -38.43 more
LEDERRIF-INH 300mg Tablet 3x10s  139.71 You can save 283.86
List of alternate brands

Manufactured / Marketed By : CCL Product Form : TabletPack Size : 100sIngredients : Rifampicin:300mg + Isoniazid:150mgGeneric Category : Anti-tuberculosis drugs

How it works

This medicine works by interfering with certain processes that help the bacteria to grow and increase in number; this ultimately leads to the death of the bacteria.

Side effects

Major & minor side effects for AFRACIN 300mg Tablet 100s

  • Dark urine
  • Loss of appetite severe
  • Nausea or Vomiting severe
  • Unusual tiredness or weakness
  • Tingling or numbness of the hands and feet
  • Convulsions (seizures) rare
  • Depression rare
  • Joint pain rare
  • Skin Rash severe
  • Unusual bleeding or bruising rare
  • Abdominal pain severe
  • Dizziness severe
  • Headache severe
  • Yellow colored eyes or skin rare
  • Muscle pain rare

Uses of AFRACIN 300mg Tablet 100s

What is it prescribed for?

  • Tuberculosis

    This medicine is used in the treatment of active tuberculosis, a type of lung infection caused by Mycobacterium tuberculosis.

Concerns

Frequently asked questions

  • Onset of action

    The amount of time required for this medicine to show its action is not clinically established.

  • Duration of Effect

    The amount of time for which this medicine remains active in the body is not clinically established.

  • Safe with Alchohol?

    Alcohol should not be consumed while receiving this medicine since it may significantly increase the risk of serious adverse effects. These adverse effects may include unusual bleeding or bruising, joint pain or swelling, fever, chills, skin rash, severe abdominal pain, yellowing of the skin or eyes, etc.

  • Is it habit forming?

    No habit-forming tendencies were reported.

  • Usage in pregnancy?

    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

  • Usage while breast-feeding?

    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

When not to use?

  • Allergy

    This medicine is not recommended for use in patients with a known allergy to isoniazid, rifampicin, or any other inactive ingredients present along with these medicines.

  • Antiviral medications

    This medicine is not recommended for use in patients receiving antiviral therapy since it may reduce the effects of antiviral medications and may lead to the development of viral resistance.

  • Severe Hepatic impairment

    This medicine is not recommended for use in patients suffering from a severe hepatic impairment or an acute liver disease due to the increased risk of worsening of the patient's condition.

Warnings

Warnings for special population
  • Pregnancy

    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

  • Breast-feeding

    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

General Warnings
  • Liver impairment

    This medicine should be used with extreme caution in patients with a known history of liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function tests and/or replacement with a suitable alternative may be required based on the clinical condition of the patient.

  • Renal impairment

    This medicine should be used with caution in patients with a known history of kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests and/or replacement with a suitable alternative may be required based on the clinical condition of the patient.

  • Diabetes

    This medicine should be used with caution in patients with a history of diabetes since it may alter the blood glucose levels. Close monitoring of blood glucose levels, appropriate patient education, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

  • Drug-resistance

    Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug-resistant.

  • Severe cutaneous reactions

    This medicine may cause severe skin reactions including Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) in some patients. Report any skin rashes or mucosal lesions to the doctor immediately. Appropriate corrective measures and/or replacement with a suitable alternative may be required based on the clinical condition of the patient.

  • Liver enzymes

    This medicine may elevate liver enzyme levels in some patients. Close monitoring of liver enzyme levels and/or replacement with a suitable alternative may be necessary in some cases based on the clinical condition of the patient.

  • Use in geriatrics

    This medicine should be used with caution in elderly patients due to the increased risk of severe adverse effects. Replacement with a suitable alternative may be required based on the clinical condition of the patient.

Dosage

  • Missed Dose

    Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

  • Overdose

    Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions

Interaction with Medicines
  • Clopidogrel moderate
  • Propranolol moderate
  • Pimozide severe
  • Warfarin severe
  • Leflunomide severe
  • Halothane severe
  • Teriflunomide severe
  • Citalopram severe
Disease interactions
  • severe

    This medicine is not recommended for use in patients with an acute liver disease or a known history of liver injury due to the use of this medicine. It should be used with caution in patients with chronic liver diseases or a history of alcoholism due to the increased risk of serious liver injuries which may be fatal. Close monitoring of liver function tests is recommended for such patients. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

  • severe

    This medicine should be used with caution in patients with a known history of peripheral neuropathy due to the increased risk of worsening of the patient's condition. Appropriate corrective measures including vitamin B6 supplementation and/or replacement with a suitable alternative may be required in some cases based on the clinical condition.

  • moderate

    This medicine should be used with caution in patients with a known history of renal diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function and/or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

  • severe

    This medicine should be used with extreme caution in patients with preexisting bone marrow depression or blood dyscrasias due to the increased risk of serious hematopoietic abnormalities. These abnormalities may include thrombocytopenia, leukopenia, decreased hemoglobin levels, acute hemolytic anemia, etc. Close monitoring of complete blood counts and/or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

  • severe

    This medicine should be used with caution in patients with a history of porphyria due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be required based on the clinical condition of the patient.

  • moderate

    This medicine should be used with caution in patients with a history of gastrointestinal diseases, particularly colitis due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative may be required based on the clinical condition of the patient.

Food interactions
  • This medicine should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal since food decreases the absorption of this medicine.

General Instructions

Take this medicine on an empty stomach, either 1 hour before or 2 hours after a meal. The absorption of this medicine may be reduced if it is taken along with food. Do not consume in larger or smaller amounts than advised. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.

Other details

  • To be taken on an empty stomach
  • To be taken as instructed by doctor
  • May cause sleepiness

References

Additional Information:

One of the following licensed pharmacy from the nearest location will deliver AFRACIN 300mg Tablet 100s. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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