Antifocine suspension 500/25 mg 15 mL
Antifocine suspension contains Sulfadoxine and Pyrimethamine | belongs to Diaminopyrimidine/Sulphonamide
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How it works
Antifocine suspension 500/25 mg 15 mL is a sulfa drug, often used in combination with pyrimethamine to treat malaria. This medicine may also be used to prevent malaria in people who are living in, or will be traveling to, an area where there is a chance of getting malaria. This drug targets Plasmodium dihydropteroate synthase and dihydrofolate reductase. Sulfa drugs or Sulfonamides are antimetabolites. They compete with para-aminobenzoic acid (PABA) for incorporation into folic acid. The action of sulfonamides exploits the difference between mammal cells and other kinds of cells in their folic acid metabolism. All cells require folic acid for growth. Folic acid (as a vitamin) diffuses or is transported into human cells. However, folic acid cannot cross bacterial (and certain protozoan) cell walls by diffusion or active transport. For this reason bacteria must synthesize folic acid from p-aminobenzoic acid.
Frequently asked questions
Onset of action
Duration of Effect
Safe with Alchohol?
Is it habit forming?
Usage in pregnancy?
Usage while breast-feeding?
- mayo clinic - Pyrimethamine And Sulfadoxine (Oral Route) [Internet]. Available from: https://www.mayoclinic.org/drugs-supplements/pyrimethamine-and-sulfadoxine-oral-route/side-effects/drg-20062761?p=1 [cited 29/6/2020]. 1/2/2020
- drugbank - Mechanism of action [Internet]. Available from: https://www.drugbank.ca/drugs/DB01299 [cited 29/6/2020]. 13/6/2020
what are the adverse effects of Antifocine suspension 500/25 mg 15 mL?
Skin rash (discontinue immediately). Pharyngitis or pruritus occurs. Gl distress, skin rashes, blood dyscrasias. Rarely erythema multiforme, Stevens-Johnson syndrome, Lyell’s syndrome.
What happens if I miss a dose of Antifocine suspension 500/25 mg 15 mL?
TABLETS: Prophylaxis: Adults: Non-immune subjects, 1 tab as a single dose once in a wk; Semi-immune subjects, 2-3 tab once every four wk. Children: Under 4 yr, quarter adult dose; 4-8 yr, half adult dose; 9-14 yr, three-quarters adult dose. The mentioned prophylactic dose is once every two wk for non-immune subjects while once every four wk for semi-immune subjects.
Treatment: Adults: Over 14 yr, 2-3 tab as a single dose. Children: Under 4 yr, 1/2 tab; 4-8 yr, 1 tab; 9-14 yr, 2 tab. All as a single dose.
SUSPENSION: Curative dose: Adults: 15 mL in single dose. Children: Single dose: Under 4 yr, 2.5 mL; 4-6 yr, 5 mL; 7-9 yr, 7.5 mL; 10- 14 yr, 10 mL.
Prophylactic dose: Adults: Non-immune subjects, 5 mL as a single dose once in a wk; Semi-immune subjects, 10-15 mL once every four wk. Children: Under 4 yr, 2.5 mL as a single dose; 4-8 yr, 5 mL as a single dose; 9-14 yr, 7.5 mL as a single dose. The mentioned prophylactic dose is once every two wk for non-immune subjects while once every four wk for semi-immune subjects.
One of the following licensed pharmacy from the nearest location will deliver Antifocine suspension 500/25 mg 15 mL. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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