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Avastin Injection 400 mg 16 mL
- Does this requires a prescription ? Yes
- Generic Name: Bevacizumab
- Manufactured by : Roche
- Drug Strength : 400 mg
- Drug Form : Injection
- Pack Size : 16 mL
- Product SKU : pg_2027_2637
Out of stock
Avastin Injection contains Bevacizumab | belongs to Monoclonal antibody
Alternate brands of Avastin Injection 400 mg 16 mL
| Brand Name | Price | Savings |
|---|---|---|
| Avastin Injection 100 mg 4 mL | ₨ 28,800.00 | You can save 85700 |
How it works
Avastin Injection 400 mg 16 mL inhibits the formation and growth of blood vessels that bring oxygen and nutrients to cancer cells. This helps in slowing the growth of the cancer cells.
Side effects
Major & minor side effects for Avastin Injection 400 mg 16 mL
- Black or Tarry stools
- Bleeding gums
- Body aches or Pain
- Burning, numbness, tingling in the arms and feet
- Chest pain
- Chills
- Cloudy urine
- Decreased urine output
- Dilated neck veins
- Fever
- Irregular breathing
- Seizures
- Sore throat
- Sweating
- Unusual bleeding or bruising
- Unusual tiredness and weakness
- Dizziness
Uses of Avastin Injection 400 mg 16 mL
What is it prescribed for?
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Colorectal Cancer
This medicine is used in the treatment of colorectal cancer. The colon and rectum are parts of the large intestine. Colorectal cancer occurs when tumors form in the lining of the large intestine.
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Non-Small Cell Lung Cancer
This medicine is used in the treatment of non-small cell lung cancer. It is a type of lung cancer characterized by symptoms such as a persistent cough, shortness of breath, weight loss, coughing up blood, etc.
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Glioblastoma Multiforme
This medicine is used in the treatment of glioblastoma multiforme, an aggressive type of brain cancer characterized by symptoms such as a headache, drowsiness, nausea, blurred vision, seizures, changes in personality, etc.
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Renal cell carcinoma
This medicine is used in the treatment of renal cell carcinoma, which is the most common type of kidney cancer.
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Cervical cancer
This medicine is used in the treatment of cervical cancer, a cancer of the cervix characterized by symptoms such as bleeding in between periods, foul-smelling white discharge, low back pain, lower abdominal pain, etc.
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Ovarian Cancer
This medicine is used in the treatment of cancer of the ovaries.
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Fallopian Tube Cancer
This medicine is used in the treatment of fallopian tube cancer.
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Peritoneal Cancer
This medicine is used in the treatment of peritoneal cancer. It develops in a thin layer of tissue that lines the abdomen called the peritoneum.
Concerns
Frequently asked questions
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Onset of action
The effect of this medicine can be observed rapidly after intravenous administration.
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Duration of Effect
The effect of this medicine lasts for an average duration of 14 days.
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Safe with Alchohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
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Is it habit forming?
No habit-forming tendencies were reported.
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Usage in pregnancy?
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
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Usage while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
When not to use?
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Allergy
This medicine is not recommended for use in patients with a known allergy to Avastin Injection 400 mg 16 mL or any other active ingredients present along with this medicine.
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Bleeding disorder
This medicine is not recommended for use in patients with significant bleeding disorders since it may worsen the patient's condition.
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Surgery
This medicine is not recommended for use for at least 28 days prior to and 28 days after a surgical procedure or until the surgical wound is fully healed due to the increased risk of serious adverse effects.
Warnings
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Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
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Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.
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Fistula formation
This medicine should be used with caution since it may cause a formation of fatal fistula involving the tracheoesophageal, bronchopleural, biliary, vaginal, renal, or bladder sites. Therapy with the medicine should be discontinued if fistula formation involving an internal organ is observed.
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Driving and Operating machinery
This medicine may cause symptoms such as dizziness, fainting, loss of balance, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.
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Bleeding
This medicine may cause severe bleeding and gastrointestinal perforations in some patients. Therapy may need to be discontinued in these patients based on the clinical condition.
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Cardiovascular diseases
This medicine should be used with caution in patients with pre-existing cardiovascular diseases due to the increased risk of worsening of the patient's condition. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
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Use in Children
This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.
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Surgeries
This medicine is not recommended for use for at least 28 days prior to and 28 days after a surgical procedure or until the surgical wound is fully healed due to the increased risk of serious adverse effects.
Dosage
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Missed Dose
Since this medicine is administered by a qualified healthcare professional in the clinical or hospital setting, the likelihood of a missed dose is very low. If you miss an appointment for a scheduled dose of this medicine, contact your doctor immediately for further instructions.
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Overdose
Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
Interactions
Interaction with Medicines- Thalidomide severe
- Deferiprone severe
- Sunitinib severe
- Topotecan moderate
-
moderate
This medicine should be used with extreme caution in patients with pre-existing hypertension due to the increased risk of worsening of the patient's condition. Close monitoring of blood pressure levels, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
General Instructions
This medicine is usually administered by a qualified healthcare professional in the hospital or clinical setting. Inform the doctor if you have a known allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine. Report any unusual and significant side effects to the doctor immediately.
Other details
- Usage does not depend on food timings
- To be taken as instructed by doctor
- May cause sleepiness
References
- practo.com - Bevacizumab [Internet]. Available from: https://www.practo.com/medicine-info/bevacizumab-1400-api [cited 2 october 2019]. 9 Apr 2018
- drugbank.ca - Bevacizumab [Internet]. Available from: https://www.drugbank.ca/drugs/DB00112 [cited 2 october 2019]. September 30, 2019
How to use Avastin Injection 400 mg 16 mL
Do not administer as an IV push or bolus. Administered only as an IV inf. Deliver the initial dose over 90 min as an IV inf following chemotherapy. If the first inf is well tolerated the second inf may be administered over 60 min. If the 60 min inf is well tolerated, all subsequent inf may be administered over 30 min.
Compatibility: Stable in NS.
Stability: Bevacizumab solutions for inf may be stored at 2°C-8°C (36°F-46°F) for upto 8 hours.
what are the adverse effects of Avastin Injection 400 mg 16 mL?
GI perforation or fistulae, tumour-associated and mucocutaneous hemorrhage, arterial and venous thromboembolism, HTN, proteinuria, CHF, immune system disorders, hypersensitivity and infusion reactions.
What happens if I miss a dose of Avastin Injection 400 mg 16 mL?
Metastatic Colon/Rectum Carcinoma: Adults: 5 mg/kg IV infusion over 90 min once every 14 day until disease progression is detected. If 1st infusion is well tolerated, administer 2nd infusion over 60 min. If 2nd infusion is well tolerated, administer subsequent doses over 30 min.
One of the following licensed pharmacy from the nearest location will deliver Avastin Injection 400 mg 16 mL. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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