₨ 240.00
MBBS
Dactinofin Injection 0.5 mg 1 Vial
- Does this requires a prescription ? Yes
- Generic Name: Dactinomycin
- Manufactured by : Pharmedic Laboratories
- Drug Strength : 0.5 mg
- Drug Form : Injection
- Pack Size : 1 vial
- Product SKU : pg_5660_7903
Dactinofin Injection contains Dactinomycin | belongs to Cytotoxic antibiotic
Alternate brands of Dactinofin Injection 0.5 mg 1 Vial
| Brand Name | Price | Savings |
|---|---|---|
| Dactinomycin Injection 0.5 mg 1 Vial | ₨ 292.00 | You will pay -52 more |
How it works
Dactinofin Injection 0.5 mg 1 Vial by inhibiting and slowing the growth of the cancer cells in the body.
Side effects
Major & minor side effects for Dactinofin Injection 0.5 mg 1 Vial
- Diarrhea
- Heartburn
- Blood in the urine or stools
- Mouth sores
- Joint pain rare
- Skin Rash
- Vomiting
Uses of Dactinofin Injection 0.5 mg 1 Vial
What is it prescribed for?
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Wilm's Tumour
This medicine is used in the treatment of Wilm's Tumour (a malignant tumor which occurs in the kidney).
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Ewing's Sarcoma
This medicine is used in the treatment of Ewing's sarcoma, a type of cancer which affects the bone or soft tissues surrounding the bone such as nerves or cartilage.
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Rhabdomyosarcoma
This medicine is used in the treatment of Rhabdomyosarcoma, a type of cancer that affects the skeletal muscle cells (rhabdomyloblasts).
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Testicular Cancer
This medicine is used in the treatment of Testicular Cancer, a type of cancer that affects the testicles where the male hormones and sperms are secreted
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Trophoblastic Disease
This medicine is used in the treatment of Trophoblastic Disease, a rare type of cancer in which trophoblast cells grow abnormally in the uterus after conception.
Concerns
Frequently asked questions
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Onset of action
The amount of time required for this medicine to show its action is not clinically established.
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Duration of Effect
The amount of time for which this medicine remains active in the body is not clinically established.
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Safe with Alchohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
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Is it habit forming?
No habit-forming tendencies were reported.
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Usage in pregnancy?
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
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Usage while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
When not to use?
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Allergy
This medicine is not recommended for use in patients with a known allergy to Dactinofin Injection 0.5 mg 1 Vial , or any other inactive ingredients present in the formulation.
Warnings
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Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
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Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
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Extravasation
This medicine should be administered only under the supervision of qualified healthcare professionals. if extravasation occurs, interrupt the infusion or injection as soon as possible and apply ice.
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Infections
Use of this medicine may affect the immune system, making you susceptible to opportunistic infections from a wide variety of pathogens. Use of this medicine is not recommended if you have an active infection. If a serious infection develops, consult your doctor immediately and discontinue the use of this medicine based on the doctor's advice.
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Liver Disease
This medicine should be used with caution in patients with liver diseases due to the increased risk of adverse effects. Regular monitoring of liver function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
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Kidney Disease
This medicine should be used with caution in patients with kidney diseases due to the increased risk of adverse effects. Regular monitoring of kidney function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
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Bone marrow suppression
This medicine should be used with caution since it may increase the risk of myelosuppression (decreased bone marrow function). Regular monitoring of blood cells count is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Dosage
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Missed Dose
Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.
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Overdose
Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
Interactions
Interaction with Medicines- Adalimumab severe
- Influenza vaccine H1N1 live severe
- Clozapine severe
- Mumps virus Vaccine severe
- Certolizumab severe
- Polio virus vaccine Live,Trivalent severe
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severe
This medicine should be used with extreme caution in patients with a history of recurrent infections due to the increased risk of myelosuppression. Initiation of therapy with this medicine in patients with active infections is not recommended. Patients susceptible to infections should be monitored closely during treatment with this medicine. An alternative treatment option may be necessary in some cases based on the clinical condition.Kidney Disease
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moderate
This medicine should be used with caution in patients with kidney disease due to the increased risk of severe adverse effects. Regular monitoring of kidney function, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
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moderate
This medicine should be used with caution in patients with liver disease due to the increased risk of severe adverse effects. Regular monitoring of liver function, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
General Instructions
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Other details
- Usage does not depend on food timings
- To be taken as instructed by doctor
- Does not cause sleepiness
References
- dailymed - DACTINOMYCIN [Internet]. Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5dc19443-1bac-4bb4-893e-e791b72b3d26 [cited 1/14/2021]. 2018
How to use Dactinofin Injection 0.5 mg 1 Vial
IV: Infuse over 10-15 min. Avoid extravasation. Extremely damaging to soft tissue and will cause a severe local reaction if extravasation occurs. Administer slow IV push over 10-15 min. An in line cellulose membrane filter should not be used during administration of Dactinomycin soln. Do not give IM or SC. Dilute with 1.1 mL of preservative-free SWFI to yield a final concentration of 500 mcg/mL; do not use preservative diluent as precipitation may occur.
Compatibility: Stable in D5W, NS, SWFI.
what are the adverse effects of Dactinofin Injection 0.5 mg 1 Vial?
Fatigue, fever, acne, alopecia (reversible), increased pigmentation, Stevens-Johnson syndrome, growth retardation, hyperuricaemia, abdominal pain, anorexia, diarrhoea, GI ulceration, nausea, vomiting, anaemia, increased bilirubin, hepatotoxicity, liver function test abnormality, erythema, oedema, myalgia.
What happens if I miss a dose of Dactinofin Injection 0.5 mg 1 Vial?
Adults: 2.5 mg/m² in divided doses, over 1 wk, repeated every 2 wk or 0.75-2 mg/m² every 1-4 wk or 400-600 mg/m²/day for 5 days, repeated every 3-6 wk. Refer to individual protocol.
One of the following licensed pharmacy from the nearest location will deliver Dactinofin Injection 0.5 mg 1 Vial. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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