Dasirox tablet Dispersible 400 mg 30’s

 4,800.00

Manufactured by:
Active Pharmaceutical Ingredient:
Drug Strength: 400 mg
Drug Form : tablet Dispersible
Pack Size : 30s
Does this requires a prescription ?Yes

Dasirox tablet Dispersible contains Deferasirox | belongs to Oral iron chelator

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    How it works

    Dasirox tablet Dispersible 400 mg 30’s is in a class of medications called iron chelators. It works by attaching to iron in the body so that it can be excreted (removed from the body) in feces.

    Side effects

    Major & minor side effects for Dasirox tablet Dispersible 400 mg 30’s

    • Nausea and vomiting
    • Dizziness
    • Earache
    • Stomach pain
    • Loss of vision or blurred vision severe
    • Hearing impairment severe
    • Black or tarry stools severe
    • Bleeding gums severe
    • Unusual tiredness or weakness severe
    • Puffing or swelling of eyelids severe
    • Unusual bleeding or bruising severe
    • Fever
    • Cough or hoarseness
    • Respiratory tract infection severe
    • Abnormal blood counts severe

    Uses of Dasirox tablet Dispersible 400 mg 30’s

    What is it prescribed for?

    • Iron overload

      This medicine is used to treat an excessive amount of iron accumulated in the body due to repeated blood transfusions.

    • Non-transfusion dependent thalassemia (NTDT)

      This medicine is used to treat an excessive amount of iron accumulated in the body due to a genetic blood disorder called non-transfusion-dependent thalassemia.

    Concerns

    Frequently asked questions

    • Onset of action

      The amount of time taken by this medicine to show its effects is not clinically established.

    • Duration of Effect

      The amount of time for which this medicine remains effective in the body is not clinically established.

    • Safe with Alchohol?

      Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

    • Is it habit forming?

      No habit-forming tendencies were reported.

    • Usage in pregnancy?

      This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.

    • Usage while breast-feeding?

      This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine. You may be advised to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

    When not to use?

    • Allergy

      This medicine is not recommended for use in patients with a known allergy to Dasirox tablet Dispersible 400 mg 30’s or any other inactive ingredients present in the formulation.

    • Poor performance status

      This medicine is not recommended for use in patients with poor performance status, which is an indicator of the ability to perform certain activities of daily living without the help of others. These activities include getting dressed, eating, working a regular job, etc.

    • Myelodysplastic syndrome

      This medicine is not recommended for use in patients with high-risk myelodysplastic syndromes, a group of disorders characterized by the inability of the bone marrow to produce healthy blood cells.

    • Advanced malignancies

      This medicine is not recommended for use in patients suffering from advanced or end-stage cancers.

    • Low platelet count

      This medicine is not recommended for use in patients with very low blood platelet counts (less than 50,000/mm3) due to the increased risk of worsening of the patient's condition.

    • Severe renal impairment

      This medicine is not recommended for use in patients with a severe impairment of kidney function (creatinine clearance less than 40 ml/min) due to the increased risk of serious adverse effects.

    • Severe liver impairment

      This medicine is not recommended for use in patients with a severe impairment of liver function (Child-Pugh Category C) due to the increased risk of serious adverse effects.

    Warnings

    Warnings for special population
    • Pregnancy

      This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.

    • Breast-feeding

      This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine. You may be advised to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

    General Warnings
    • Other medicines

      This medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you report all your current medicines, including any herbs and supplements, to the doctor before beginning treatment with this medicine.

    • Pediatric use

      Use of this medicine in children is condition specific. For treating iron overload, it should not be used in children less than 2 years of age. For treating thalassemia, it should not be used in children less than 10 years of age.

    • Clinical monitoring

      Your doctor may conduct regular tests to obtain the serum ferritin and liver iron concentration values during treatment with this medicine. These parameters play a crucial role in determining the dose regimen and therapy duration. You may also be asked to undergo other blood tests during the course of treatment with this medicine.

    • Form based dosing

      The dose regimen of this medicine is likely to vary based on the form. You are advised to not change from conventional tablets to tablets for suspension or dispersible tablets and vice versa without consulting the doctor.

    • Liver diseases

      This medicine should be used with caution in patients with an impaired liver function due to the increased risk of severe adverse effects. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the patient's condition. It should not be used in patients suffering from a severe liver function impairment.

    • Kidney diseases

      This medicine should be used with caution in patients with an impaired kidney function due to the increased risk of severe adverse effects. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the patient's condition. It should not be used in patients suffering from a severe kidney function impairment.

    • Use in elderly

      This medicine should be used with caution in the elderly patients due to the increased risk of severe adverse effects. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the patient's condition.

    • Severe allergic reaction

      Use of this medicine may cause severe and life-threatening allergic reactions in some patients. The use should be discontinued as early as possible in such cases and appropriate corrective measures should be initiated.

    • Gastrointestinal disorders

      This medicine should be used with extreme caution in patients with a history of gastrointestinal disorders including gastric bleeding, ulceration, or blockage since it may worsen the patient's condition. This risk is especially higher if the patient is receiving other medicines which irritate the gastrointestinal tract (e.g. NSAIDs). Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the patient's condition.

    Dosage

    • Missed Dose

      Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped. Do not use extra medicine to make up for the missed dose.

    • Overdose

      Seek emergency medical treatment or contact the doctor in case of an overdose.

    Interactions

    Interaction with Medicines
    • Dexamethasone severe
    • Heparin severe
    • Celecoxib severe
    • Amlodipine moderate
    • Albendazole moderate
    • Cisplatin severe
    • Gentamicin severe
    • Estradiol moderate
    • Prednisone severe
    • Paracetamol severe
    • Atorvastatin moderate
    • Aspirin severe
    • Abciximab severe
    • Balsalazide severe
    • Antacids containing aluminum moderate
    Disease interactions
    • severe

      This medicine should be used with extreme caution in patients with a bone marrow disorder or an abnormal blood count due to the increased risk of worsening of the patient's condition. Use is not recommended if the platelet count is extremely low. Close monitoring of complete blood counts is recommended during therapy with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the patient's clinical condition.

    • severe

      This medicine should be used with caution and monitoring in patients with mild to moderate impairment of normal liver function. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the patient's clinical condition. This medicine is not recommended for use in patients with a severe liver function impairment.

    • severe

      This medicine should be used with caution and monitoring in patients with mild to moderate impairment of normal kidney function. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the patient's clinical condition. This medicine is not recommended for use in patients with a severe kidney function impairment.

    • moderate

      This medicine should be used with caution in patients suffering from gastrointestinal diseases such as ulcers, hemorrhages, blockages, etc. due to the increased risk of worsening of the patient's condition. Close monitoring of clinical condition, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the patient's condition.

    Food interactions
    • Report the use of medical/non-medical caffeine to the doctor. Using caffeine or caffeine-containing products and this medicine may increase the risk of severe side effects. You may require a dose adjustment and more frequent clinical monitoring to safely use caffeine and this medicine together. Avoid or limit the use of caffeine-containing products during therapy with this medicine.

    General Instructions

    Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller quantities than recommended. You may be asked to undergo certain tests on a regular basis before and during the course of treatment with this medicine. Report any undesired side effects to your doctor. Do not stop the use of this medicine without consulting your doctor.

    Other details

    • To be taken before food
    • To be taken as instructed by doctor
    • May cause sleepiness

    References

    Additional Information>

    what are the adverse effects of Dasirox tablet Dispersible 400 mg 30’s?

    Most common: Nausea, vomiting, diarrhoea, abdominal pain, rash, non-progressive increase in serum creatinine, increased transaminases, abdominal distension, constipation, dyspepsia, proteinuria, headache. Uncommon (potentially serious): Severe skin rash, maculopathy, hepatitis; high frequency hearing loss, early cataracts.

    What happens if I miss a dose of Dasirox tablet Dispersible 400 mg 30’s?

    Recommended starting daily dose: Initially 20 mg/kg once daily. Patients receiving gt;14 mL/ kg/mth of packed RBC (lt;4 u/mth), & for reduction of Fe overload 30 mg/kg. Patients receiving lt;7 mL/kg/mth of packed RBC (lt;2 u/mth), & for maintenance of Fe level 10 mg/kg. For patients well managed on treatment with deferoxamine. See literature.

    One of the following licensed pharmacy from the nearest location will deliver Dasirox tablet Dispersible 400 mg 30’s. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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