Dobutamine Injection 250 mg 1 Ampx20 mL

 444.68

Manufactured by:
Active Pharmaceutical Ingredient:
Drug Strength: 250 mg
Drug Form : Injection
Pack Size : 1 Ampx20 mL
Does this requires a prescription ?Yes

Dobutamine Injection contains Dobutamine | belongs to Beta-1 agonist

SKU: pg_6684_9228 Categories: ,

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    How it works

    Dobutamine Injection 250 mg 1 Ampx20 mL stimulates heart muscle and improves blood flow by helping the heart pump better.

    Side effects

    Major & minor side effects for Dobutamine Injection 250 mg 1 Ampx20 mL

    • Increased heart rate severe
    • Chest pain
    • Changes in blood pressure
    • Narrowing of blood vessels severe
    • Irregular heartbeat severe
    • Headache
    • Chest tightness
    • Shortness of breath
    • Increase in white blood cell count severe
    • Unusual bleeding or bruising severe
    • Increased urination frequency
    • Nausea
    • Skin rash and itching
    • Fever
    • Swelling and redness at the injection site
    • Fast and uncontrolled contractions of the ventricles severe
    • Restlessness severe
    • Shaking and trembling of arms and feet rare
    • Anxiety and confusion severe
    • Muscle cramps and stiffness rare

    Uses of Dobutamine Injection 250 mg 1 Ampx20 mL

    What is it prescribed for?

    • Congestive Heart Failure

      This medicine is used for the short-term treatment of heart failure associated with a heart attack or other heart disorders. It is also used for improving heart function in patients who are undergoing open heart surgery or are on a ventilator. It is also used as a short-term treatment option for cardiac decompensation due to weakened heart muscles.

    Concerns

    Frequently asked questions

    • Onset of action

      The effects of this medicine can be observed within 1 to 10 minutes of parenteral administration.

    • Duration of Effect

      The effects of this medicine last for an average duration of 10 minutes.

    • Safe with Alchohol?

      Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

    • Is it habit forming?

      No habit-forming tendencies were reported.

    • Usage in pregnancy?

      This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.

    • Usage while breast-feeding?

      This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine. You may be advised to discontinue breastfeeding during treatment with this medicine.

    When not to use?

    • Allergy

      This medicine is not recommended for use in patients with a known allergy to Dobutamine Injection 250 mg 1 Ampx20 mL , sodium metabisulphite, or any other inactive ingredients present along with it.

    • Obstructive heart disease

      This medicine is not recommended for use in patients with a narrowing or obstruction in the heart or blood vessels that prevents the heart from filling or pumping blood properly due to the increased risk of worsening of the patient’s condition.

    • Hypovolemia

      This medicine is not recommended for use in patients with a very low blood volume or an inadequate circulatory filling due to the increased risk of worsening of the patient’s condition.

    • Pheochromocytoma

      This medicine is not recommended for use in patients with pheochromocytoma, a tumor of the adrenal glands that causes increased secretion of adrenal hormones, since it may worsen the patient's condition.

    Warnings

    Warnings for special population
    • Pregnancy

      This medicine is not recommended for use in pregnant women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine.

    • Breast-feeding

      This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Your doctor will determine the best course of treatment after evaluating the potential benefits and risks associated with the use of this medicine. You may be advised to discontinue breastfeeding during treatment with this medicine.

    General Warnings
    • Other medicines

      Dobucin Injection may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

    • Use in elderly

      This medicine should be used with caution and monitoring in elderly patients since the risk of adverse effects is significantly high. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

    Dosage

    • Missed Dose

      Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.

    • Overdose

      Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.

    Interactions

    Interaction with Medicines
    • Amitriptyline severe
    • Insulin moderate
    • Formoterol moderate
    • Salmeterol moderate
    • Beta blockers moderate
    • Glimepiride moderate
    • Digoxin moderate
    • Desvenlafaxine moderate
    • Linezolid severe
    • Cimetidine moderate
    • Metformin moderate
    Disease interactions
    • severe

      This medicine should be administered with extreme caution in patients with asthma due to the increased risk of worsening of the patient’s condition. Formulations containing sodium metabisulfite should not be administered, particularly in patients with a known history of allergy to sulfites. An alternative treatment option should be considered based on the clinical condition of the patient.

    • severe

      This medicine should be administered with caution in patients with a heart rhythm disorder due to the increased risk of worsening of the patient’s condition. Appropriate corrective measures, dose adjustments, or more frequent clinical monitoring are required to safely use this medicine. An alternative treatment option may be considered based on the clinical condition of the patient.

    • moderate

      This medicine should be administered with caution in patients with reduced levels of potassium in the blood (hypokalemia). Frequent monitoring of blood potassium levels with appropriate electrolyte replacement may be required in some cases based on the patient's clinical condition.

    General Instructions

    This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.

    Other details

    • Usage does not depend on food timings
    • To be taken as instructed by doctor
    • Does not cause sleepiness

    References

    Additional Information>

    How to use Dobutamine Injection 250 mg 1 Ampx20 mL

    IV: Always administer via inf device; administer into large vein.
    Reconstitution: Dilute concentrate with at least 50 mL compatible IV soln. A common dilution is 500 mg (40 mL from 250 mL bag) in 210 mL D5W or NS to yield 2000 mcg/mL or dilute 1000 mg (80 mL from 250 mL bag) in 170 mL D5W or NS to yield 4000 mcg/mL. Adjust max conc. according to patient’s fluid requirements as prescribed. Do not exceed 5000 mcg/mL.
    Compatibility: Stable in D5LR, D5 ½NS, D5NS, D5W, D10W, LR, ½NS, NS, mannitol 20%.
    Y-site administration:
    Drug to Drug IV Compatibility: Amikacin, amiodarone, aztreonam, cimetidine, ciprofloxacin, cisatracurium, diltiazem, dopamine, enalapril, epinephrine, esmolol, famotidine, fentanyl, fluconazole, gentamicin, hydromorphone, labetalol, levofloxacin, linezolid, meropenem, methylprednisolone, metoclopramide, milrinone, morphine, nitroglycerin, norepinephrine, ondansetron, phenylephrine, propofol, ranitidine, tobramycin, vancomycin, vasopressin, vecuronium.
    Drug to Drug IV Incompatibility: Acyclovir, alatrofloxacin, alteplase, aminophylline, amphotericin B, cefepime, ceftriaxone, cephazolin, dexamethasone, digoxin, foscarnet, furosemide, heparin, hydrocortisone, indomethacin, insulin regular, lansoprazole, midazolam, pantoprazole, phytonadione, piperacillin/tazobactam, thiopental, warfarin.
    In syringe: Incompatible with doxapram.
    When admixed: Incompatible with acyclovir, alteplase, aminophylline, bumetanide, calcium gluconate, diazepam, digoxin, floxacillin, furosemide, insulin regular, magnesium sulphate, phenytoin, potassium phosphate, sodium bicarbonate.
    Stability: Remix soln every 24 hrs. Store reconstituted soln under refrigeration for 48 hrs or 6 hrs at room temp. Pink discoloration of soln indicates slight oxidation but no significant loss of potency. Stability of parenteral admixture at room temp (25°C) is 48 hrs; at refrigeration (4°C) stability is 7 days.

    what are the adverse effects of Dobutamine Injection 250 mg 1 Ampx20 mL?

    Nausea; hypotension, hypertension (marked increase in systolic blood pressure indicates overdose), arrhythmias, palpitations, chest pain; dyspnoea, bronchospasm; headache; fever; increased urinary urgency; eosinophilia; rash, phlebitis; very rarely myocardial infarction, hypokalaemia; coronary artery spasm and thrombocytopenia also reported.

    What happens if I miss a dose of Dobutamine Injection 250 mg 1 Ampx20 mL?

    Adults: 2.5-20 mcg/kg/min; max: 40 mcg/kg/min, titrate to desired response.
    Children: Inotropic support in low cardiac output states, after cardiac surgery, cardiomyopathies, shock: Continuous IV infusion. Neonate, initially 5 mcg/kg/minute, adjusted according to response to 2-15 mcg/ kg/minute; max. 20 mcg/kg/minute; 1 mth-18 yr, initially 5 mcg/kg/minute adjusted according to response to 2-20 mcg/kg/minute.

    One of the following licensed pharmacy from the nearest location will deliver Dobutamine Injection 250 mg 1 Ampx20 mL. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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