Donataxel Injection 80 mg 1 Vial

 20,000.00

Manufactured by:
Active Pharmaceutical Ingredient:
Drug Strength: 80 mg
Drug Form : Injection
Pack Size : 1 vial

Donataxel Injection contains Docetaxel | belongs to Taxane

SKU: pg_6774_9352 Categories: ,

Alternate brands of Donataxel Injection 80 mg 1 Vial

Brand Name Price Savings
Texot Injection 20 mg 1 Vial  8,000.00 You can save 12000
Taxotere Concentrate Injection 80 mg 1 Vialx4 mL  20,000.00 You can save 0
Taxotere Concentrate Infusion 20 mg 1 Vial  8,000.00 You can save 12000
Taxotere Infusion 20 mg 1 Vial  10,384.20 You can save 9615.8
Mebrexel Injection 80 mg 1 Vial  20,000.00 You can save 0
List of alternate brands

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How it works

Donataxel Injection 80 mg 1 Vial exhibits cytotoxic activity on breast, colorectal, lung, ovarian, gastric, renal and prostate cancer cells. It does not block disassembly of interphase microtubules and so does not prevent entry into the mitotic cycle, but does block mitosis by inhibiting mitotic spindle assembly.

Side effects

Major & minor side effects for Donataxel Injection 80 mg 1 Vial

  • Burning, numbness, tingling in the arms and feet severe
  • Swelling of the face, arms, hands, lower legs, or feet severe
  • Weight gain severe
  • Fever and chills severe
  • Dizziness severe
  • Skin rash severe
  • lower back pain severe
  • Chest discomfort severe
  • Diarrhea
  • Sore throat
  • Nausea and Vomiting
  • Headache
  • Swelling and redness at the injection site

Uses of Donataxel Injection 80 mg 1 Vial

What is it prescribed for?

  • Breast cancer

    Donataxel Injection 80 mg 1 Vial is used in the treatment of breast cancer.

  • Non-Small Cell Lung Cancer

    Donataxel Injection 80 mg 1 Vial is used in the treatment of Non-Small Cell Lung Cancer which is a type of cancer that affects the lungs.

  • Prostate Cancer

    Donataxel Injection 80 mg 1 Vial is used in the treatment of prostate cancer which is a most common type of cancer in the men.

  • Gastric Cancer

    Donataxel Injection 80 mg 1 Vial is used in the treatment of gastric cancer that develops in the lining of the stomach.

  • Head and Neck Cancer

    Donataxel Injection 80 mg 1 Vial is used in the treatment of head and neck cancer that affects mouth, nose and throat and salivary glands.

Concerns

Frequently asked questions

  • Onset of action

    The peak effect of this medicine can be observed in less than an hour.

  • Duration of Effect

    The effect of this medicine lasts for an average duration of 11 hours.

  • Safe with Alchohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    No habit forming tendencies were reported.

  • Usage in pregnancy?

    This medicine is not recommended for pregnant women.

  • Usage while breast-feeding?

    This medicine is not recommended in breastfeeding women.

When not to use?

  • Allergy

    Not recommended in the patients with known allergy to Donataxel Injection 80 mg 1 Vial .

  • Neutrophils count

    Not recommended in the patients with neutrophils count less than 1,500 cells/mm3

Warnings

Warnings for special population
  • Pregnancy

    This medicine is not recommended for pregnant women.

  • Breast-feeding

    This medicine is not recommended in breastfeeding women.

General Warnings
  • Blood cell count

    This medicine may lower the white blood cell count (neutrophils). Close monitoring of blood cell count is necessary. Do not start the treatment if the neutrophils count is less than 1500 cells/mm3.

  • Allergy

    This medicine may cause serious skin reactions. Discontinue the treatment if any symptoms of allergy appear and do not restart.

  • Fluid accumulation

    This medicine may cause swelling of feet and hands. Patients should be given with a corticosteroid dose to reduce the severity of fluid accumulation. Any symptoms of swelling of limbs should be reported to the doctor. Close monitoring of patients body weight is necessary.

  • Neurologic reactions

    This medicine is known to cause nerve damage. Any symptoms of tingling or burning sensation and pain should be reported to the doctor. Dose adjustments are to be made based on the clinical condition. Discontinue the treatment if the symptoms persist.

  • Eye disorders

    This medicine is known to cause cystoid macular edema which is an eye disorder. Discontinue the treatment if any symptoms of impaired vision are observed.

  • Impaired function

    This medicine is not recommended in the patients with the liver injury. The concentration of this medicine may increase in these patients. The baseline of the liver function tests should be obtained before starting the treatment.

  • Infections

    The chances of occurring infections are more in the patients receiving this medicine. Hold the chemotherapy and start with the broad-spectrum antibiotics if there are any signs and symptoms of fever. Close monitoring of the body temperature and the blood cell count is necessary.

Dosage

  • Missed Dose

    It is advised not to miss any dose. If you missed any dose, you should contact your doctor immediately.

  • Overdose

    Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions

Interaction with Medicines
  • Clozapine severe
  • Diltiazem moderate
  • Atorvastatin moderate
  • Live vaccines severe
Disease interactions
  • severe

    This medicine can suppress the immune system of the body. Hold the chemotherapy and start with the broad-spectrum antibiotics if there are any signs and symptoms of fever. Close monitoring of the body temperature and the blood cell count is necessary.

General Instructions

This medicine is given in multiple cycles. It is important to receive the every scheduled dose and make a note of next scheduled dose. Close monitoring of liver enzymes and blood cells count especially, neutrophils is necessary.

Other details

  • Usage does not depend on food timings
  • To be taken as instructed by doctor
  • May cause sleepiness

References

Additional Information>

How to use Donataxel Injection 80 mg 1 Vial

IV: Irritant. Anaphylactoid-like reactions have been reported: Pre-medication with dexamethasone (4-8 mg orally twice daily for 3 or 5 days starting 1 day prior to administration of docetaxel). Prevention of fluid retention (e.g. pleural effusion, ascites, peripheral oedema); Patients receiving docetaxel should be treated with a steroid (e.g. dexamethasone 8-10 mg orally twice daily) for 3-5 days, beginning the day before docetaxel administration. Administer IV infusion over 1 hour through non-absorbing (non-polyvinylchloride) tubing; in-line filter is not necessary. When administered as sequential infusions, taxane derivatives should be administered before platinum derivatives (cisplatin, carboplatin) to limit myelosuppression and to enhance efficacy. Intact vials of solution should be diluted with 13% (w/w) ethanol/water to a final concentration of 10 mg/mL. Docetaxel dose should be further diluted with 0.9% NS or D5W to a final concentration of 0.3-0.9 mg/mL and must be prepared in a glass bottle, polypropylene, or polyolefin plastic bag to prevent leaching of plasticizers.
Compatibility: Stable in D5W, NS.
Stability: Refrigerate at 2°C-25°C. Protect it from exposure to light. Allow vial to stand at room temperature for 5 min prior to reconstitution. After reconstitution, may be stored refrigerated or at room temperature for up to 8 hours.

what are the adverse effects of Donataxel Injection 80 mg 1 Vial?

Neutropenia, thrombocytopenia, anaemia, hypersensitivity reactions, cutaneous reactions, fluid retention, peripheral neuropathy, mucositis, arthralgia, myalgia, increase in liver enzyme.

What happens if I miss a dose of Donataxel Injection 80 mg 1 Vial?

Adults: Breast Cancer: 60-100 mg/m² IV over 1 hr every 3 wk. Dosage adjustment may be required.
Adjuvant Treatment Operable Node-Positive Breast CA: Neutrophil Count gt;1500 cells/cubic mm: 75 mg/m² 1 hr after doxorubicin 50 mg/m² and cyclophosphamide 500 mg/m² every 3 wk x 6 courses. Dosage adjustment may be required.
Non-Small Cell Lung Cancer: 75 mg/m² IV over 1 hr every 3 wk. Dosage adjustment may be required.
Hormone-Refractory Metastatic Prostate Cancer: 75 mg/m² IV over 1 hr every 3 wk with prednisone 5 mg twice daily. Dosage adjustment may be required.
Children: Not recommended.

One of the following licensed pharmacy from the nearest location will deliver Donataxel Injection 80 mg 1 Vial. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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