₨ 752.87
MBBS
Epival CR tablet 500 mg 5×10’s
- Does this requires a prescription ? Yes
- Generic Name: Divalproex Sodium
- Manufactured by : Abbott
- Drug Strength : 500 mg
- Drug Form : CR tablet
- Pack Size : 5x10s
- Product SKU : pu_pg_7627_10527
Epival CR tablet contains Divalproex Sodium | belongs to Carboxylic acid derivative
Alternate brands of Epival CR tablet 500 mg 5×10’s
| Brand Name | Price | Savings |
|---|---|---|
| Wiproate tablet 500 mg 10×10’s | ₨ 423.17 | You can save 452.27 |
| Wiproate tablet 250 mg 10×10’s | ₨ 320.62 | You can save 554.82 |
| Volpar CR tablet 500 mg 3×10’s | ₨ 107.18 | You can save 768.26 |
| Volpar tablet 250 mg 10×10’s | ₨ 355.24 | You can save 520.2 |
| Valrox syrup 250 mg 120 mL | ₨ 110.00 | You can save 765.44 |
How it works
It works by binding to the receptors in the brain and inhibits the excitation of brain cells.
Uses of Epival CR tablet 500 mg 5×10’s
What is it prescribed for?
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Epilepsy
Epival CR tablet 500 mg 5×10’s is used in the treatment of Epilepsy which is a brain disorder that causes repeated seizures. Uncontrolled jerking movements and loss of consciousness are some of the symptoms of Epilepsy.
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Mania
Epival CR tablet 500 mg 5×10’s is used in the treatment of mania which is a mental disorder characterized by hyperactivity and racing thoughts.
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Migraine Prophylaxis
Epival CR tablet 500 mg 5×10’s is used as prophylaxis in migraine headaches characterized by severe headache, eye pain, nausea and vomiting.
Concerns
Frequently asked questions
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Onset of action
The peak effect of this medicine can be observed in 2 hours for a delayed release tablet.
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Duration of Effect
The effect of this medicine lasts for an average of 1 to 2 days.
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Safe with Alchohol?
Consumption of alcohol with this medicine is not recommended as it increases the risk of side effects like dizziness, difficulty in concentration. Do not perform activities that require mental alertness like driving or operating machinery.
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Is it habit forming?
No habit forming tendency has been reported
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Usage in pregnancy?
This medicine is not recommended for pregnant women.
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Usage while breast-feeding?
This medicine is recommended only if clearly needed when no safer alternative is available. Monitoring of undesired effects like discoloration of eyes and skin is necessary.
When not to use?
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Allergy
Do not take this medicine if you have a known allergy to Epival CR tablet 500 mg 5×10’s .
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Liver disease
Do not take if you have any liver injury or a family history of liver injury.
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Urea cycle disorders
Do not use in patients with urea cycle disorder (high ammonium levels in the blood) or family history of urea cycle disorder.
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Mitochondrial disorders
Do not use in patients and in children who are suspected to have the mitochondrial disorder (POLG e.g Alpers-Huttenlocher Syndrome).
Warnings
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Pregnancy
This medicine is not recommended for pregnant women.
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Breast-feeding
This medicine is recommended only if clearly needed when no safer alternative is available. Monitoring of undesired effects like discoloration of eyes and skin is necessary.
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Pancreatitis
Epival CR tablet 500 mg 5×10’s may cause Pancreatitis which is a serious life-threatening reaction. Discontinue the medicine if Pancreatitis is detected and an alternate medicine should be considered.
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Bleeding disorder
Use with caution in patients with the bleeding disorder as it may cause Thrombocytopenia. Make necessary dosage adjustments or discontinue the medicine if this condition is identified.
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Suicidal behavior
Epival CR tablet 500 mg 5×10’s may increase the risk of suicidal thoughts. It should be used with caution and prescription size should be limited in patients with depression or suicidal tendencies.
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Pediatric use
Epival CR tablet 500 mg 5×10’s is not recommended in children less than 2 years of age due to the increased risk of liver injury.
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Geriatric use
Use with caution in the elderly population as it may lead to dizziness. The safety and efficacy of this medicine in the prophylaxis of migraines is not established.
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Impaired liver function
This medicine is not recommended in patients with liver injury or a family history of liver injury.
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Impaired kidney function
Use with caution in the patients with the kidney injury. Suitable dose adjustments are to be made based on the clinical condition.
Dosage
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Missed Dose
If you miss a dose of Epival CR tablet 500 mg 5×10’s , take the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.
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Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
Interactions
Interaction with Medicines- Lamotrigine severe
- Metoclopramide moderate
- Warfarin moderate
- Ethinyl Estradiol moderate
- Imipenem severe
General Instructions
Take Epival CR tablet 500 mg 5×10’s with or without food. Do not take in larger amounts than advised. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine without consulting your doctor as it may cause seizures.
References
- practo.com - Divalproex [Internet]. Available from: https://www.practo.com/medicine-info/divalproex-87-api [cited 20 september 2019]. 20 Mar 2017
- dailymed.nlm.nih.gov - Divalproex [Internet]. Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f911748c-fb3a-fe1a-ab2a-4b40455e05ef [cited 20 september 2019]. March 25, 2019
- medlineplus.gov - Divalproex [Internet]. Available from: https://medlineplus.gov/druginfo/meds/a682412.html [cited 20 september 2019]. 11 September 2019
How to use Epival CR tablet 500 mg 5×10’s
IV: Following dilution to final concentration, administer over 60 min at a rate of lt;20 mg/min. Alternatively, single doses upto 15 mg/kg have been administered as a rapid infusion over 5-10 min (1.5-3 mg/kg/min).
Reconstitution: Injection should be diluted in 50 mL of a compatible diluent.
Compatibility: Physically compatible and chemically stable in D5W, NS and LR for at least 24 hours when stored in glass or PVC. See manufacturer direction.
Stability: Store vial at room temperature 15°C-30°C.
what are the adverse effects of Epival CR tablet 500 mg 5×10’s?
GI upset, weight gain, hair loss, angioedema, thrombocytopenia, agranulocytosis, bone-marrow failure, rash, pancreatitis.
What happens if I miss a dose of Epival CR tablet 500 mg 5×10’s?
Adults: ORAL: Complex Partial Seizures: Initial: 10-15 mg/kg/day. Titrate: Increase by 5-10 mg/kg/wk. Max: 60 mg/kg/day.
Absence Seizures: Initial: 15 mg/kg/day. Titrate: Increase by 5-10 mg/kg/wk. Max: 60 mg/kg/day.
Bipolar Disorder: Manic Episodes: Initial: 750 mg in divided doses. Titrate: Increase rapidly to clinical effect. Max: 60 mg/kg/day.
Migraine prophylaxis: Starting dose 250 mg twice daily, some patients may benefit from upto 1000 mg/day.
Adults: INJECTION: Initiation of valproate treatment by IV administration. Initially 10 mg/kg (usually 400-800 mg) by IV injection (over 3-5 mins) followed by IV infusion or IV injection (over 3-5 mins) in 2-4 divided doses or by continuous IV infusion up to max 2.5 gm daily; usual range 1-2 gm daily(20-30 mg/kg daily).
Children: All forms of epilepsy: ORAL: Neonate, initially 20 mg/kg once daily; usual maintenance dose 10 mg/kg twice daily; 1 mth-12 yr, initially 10-15 mg/kg (max 600 mg) daily in 1-2 divided doses; usual maintenance dose 25-30 mg/kg daily in 2 divided doses (up to 60 mg/kg daily in 2 divided doses in infantile spasms; monitor clinical chemistry and haematological parameters); 12-18 yr, initially 600 mg daily in 1-2 divided doses increased gradually (in steps of 150-300 mg) every 3 days; usual maintenance dose 1-2 gm/day in 2 divided doses. max 2.5 gm/day in 2 divided doses. INJECTION: IV: If switching from oral therapy to IV therapy give current oral daily dose by IV injection or intermittent IV infusion in 2-4 divided doses, or by continuous IV infusion. Neonate, IV injection 10 mg/kg twice daily; 1 mth-12 yr, initially 10 mg/kg by IV injection, followed by continuous IV infusion, or by intermittent IV infusion or IV injection in 2-4 divided doses up to usual range 20-40 mg/kg daily (monitor clinical chemistry and haematological parameters); 12-18 yr, initially 10 mg/kg by IV injection, followed by continuous IV infusion, or by intermittent IV infusion or IV injection in 2-4 divided doses up to max 2.5 gm daily; usual range 1-2 gm daily (20-30 mg/kg/day).
One of the following licensed pharmacy from the nearest location will deliver Epival CR tablet 500 mg 5×10’s. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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4 reviews for Epival CR tablet 500 mg 5×10’s
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bilal Hassan –
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