
MBBS
evrysdi powder for oral solution 0.7mg/ml
How it Works:
Evrysdi (risdiplam) is a medication used in the treatment of spinal muscular atrophy (SMA), a genetic neuromuscular disorder characterized by progressive muscle weakness and atrophy. Risdiplam works by increasing the production of survival motor neuron (SMN) protein, which is deficient in individuals with SMA due to mutations in the SMN1 gene.
Risdiplam acts as a small molecule splicing modifier that targets the SMN2 gene, a backup gene that produces low levels of functional SMN protein. By modifying the splicing of SMN2 pre-mRNA, risdiplam promotes the inclusion of exon 7 in the mature mRNA transcript, leading to the production of full-length SMN protein. Increased levels of functional SMN protein help improve motor neuron function, prevent muscle degeneration, and preserve motor function in individuals with SMA.
Side Effects:
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Fatigue
- Headache
- Upper respiratory tract infection
- Fever
- Decreased appetite
- Rash
Indications:
- Treatment of spinal muscular atrophy (SMA) in pediatric and adult patients
Contraindications:
- Hypersensitivity to risdiplam or any components of the medication
- Severe hepatic impairment
- History of significant cardiac arrhythmias
- Pregnancy and breastfeeding
Price Comparison in Different Countries
Country | Price (USD) | Source |
---|---|---|
United States | $340 per 60 mL | WebMD – Evrysdi Oral |
United Kingdom | £300 per 60 mL | Medicines.org.uk – Evrysdi Oral Solution |
Australia | $450 per 60 mL | Chemist Warehouse – Evrysdi Oral Solution |
Canada | $400 per 60 mL | Costco – Evrysdi Oral Solution |
India | ₹25,000 per 60 mL | 1mg – Evrysdi Oral Solution |
Top 5 Global Brands:
- Evrysdi (Generic)
- Risdiplam (Roche)
- Risdiplam Oral Solution (F. Hoffmann-La Roche Ltd.)
- SMArt (PTC Therapeutics)
- Ridizplam (Cipla Limited)
One of the following licensed pharmacy from the nearest location will deliver evrysdi powder for oral solution 0.7mg/ml. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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