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Information on this page was last modified on : 2021/05/08 3:35:44 PM

Exosurf Neonatal Injection 1’s

Belongs to Category,

Exosurf Neonatal Injection contains Colfosceril | belongs to Lung surfactant

How it works

Exosurf Neonatal Injection 1’s works by reducing the surface tension within the alveoli of the lungs and improves breathing.

Side effects

Major & minor side effects for Exosurf Neonatal Injection 1’s

  • Bleeding from lungs rare
  • Irregular heart rate rare

Uses of Exosurf Neonatal Injection 1’s

What is it prescribed for?

  • Neonatal Respiratory Distress Syndrome

    This medicine is used for the prevention and treatment of respiratory distress syndrome (RDS) in newborn babies with a birth weight of 700 grams or greater, undergoing mechanical ventilation. It occurs when the baby's lung function decreases which may lead to serious breathing difficulties.


Frequently asked questions

  • Onset of action

    The amount of time required for this medicine to show its action is not clinically established.

  • Duration of Effect

    The amount of time for which this medicine remains active in the body is not clinically established.

  • Safe with Alchohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    No habit-forming tendencies were reported

  • Usage in pregnancy?

    This medicine is not recommended for use in pregnant women.

  • Usage while breast-feeding?

    This medicine is not recommended for use in breastfeeding women.

When not to use?

  • Congenital Abnormalities

    This medicine is not recommended for use in newborn infants with congenital abnormalities or congenital infections due to the risk of worsening of the infant's condition.


Warnings for special population
  • Pregnancy

    This medicine is not recommended for use in pregnant women.

  • Breast-feeding

    This medicine is not recommended for use in breastfeeding women.

General Warnings
  • Birth weight

    Care must be taken for use in newborn babies whose birth weight is less than 700 gms due to an increase in the risk of pulmonary hemorrhage (bleeding from lungs) and other severe adverse effects. Close monitoring of heart rate and arterial oxygenation is recommended during treatment with this medicine.

  • Intratracheal administration

    The medicine should be administered through intratracheal route only.

  • Mucous plugging

    In newborns whose ventilation becomes notably impaired during or immediately after the therapy with this medicine may have mucus plugging of the endotracheal tube. Therefore, it is recommended to perform suctioning of all newborns to avoid endotracheal tube obstruction due to mucous plugging.


  • Missed Dose

    Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.

  • Overdose

    Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.

General Instructions

This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor about all the current medicines as well as medical conditions of your infants before beginning treatment with this medicine.

Other details

  • Usage does not depend on food timings
  • To be taken as instructed by doctor
  • Does not cause sleepiness


Additional Information:

How to use Exosurf Neonatal Injection 1’s

Intratracheal: For intratracheal administration only. Suction infant prior to administration, inspect solution to verify complete mixing of the suspension. Administer via side port on the special ETT adapter without interrupting mechanical ventilation. Administer the dose in two 2.5 mL/kg aliquots. Each half-dose is instilled slowly over 1-2 min in small bursts with each inspiration. After the first 2.5 mL/kg dose turn the infants head and torso 45 degree right for 30 seconds, then return to the midline position and administer the second dose as above. Following the second dose, turn the infant’s head and torso 45 degree to the left for 30 seconds and return the infant to the midline position.

what are the adverse effects of Exosurf Neonatal Injection 1’s?

Rarely, pulmonary haemorrhage.

What happens if I miss a dose of Exosurf Neonatal Injection 1’s?

Intratracheal: Prophylactic treatment: Give 5 mL/kg as soon as possible; the 2nd and third dose should be administered at 12 and 24 hr later to those infants remaining on ventilators.
Rescue treatment: Give 5 mL/kg as soon as the diagnosis of RDS is made. The 2nd 5 mg/kg dose should be administered 12 hr later.

One of the following licensed pharmacy from the nearest location will deliver Exosurf Neonatal Injection 1’s. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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