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Information on this page was last modified on : 2020/06/26 4:20:04 PM

Gramcef Injection 1 gm 1 Vial

Belongs to Category,

Gramcef Injection contains Ceftazidime | belongs to Cephalosporin

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How it works

Gramcef Injection 1 gm 1 Vial is a broad spectrum antibiotic. It works by interfering with the bacterial cell wall synthesis.

Side effects

Major & minor side effects for Gramcef Injection 1 gm 1 Vial

  • Abdominal pain severe
  • Bloating severe
  • Diarrhea severe
  • Fever severe
  • Swelling and redness at the injection site severe
  • White patches in the mouth or on the tongue severe
  • Dizziness
  • Fast heartbeat
  • Headache
  • Skin rash
  • Yellow colored eyes or skin

Uses of Gramcef Injection 1 gm 1 Vial

What is it prescribed for?

  • Bacterial Meningitis

    Gramcef Injection 1 gm 1 Vial is used in the treatment of meningitis, which is an inflammation of the protective membranes that surround the brain and spinal cord, caused by Streptococcus pneumoniae and Neisseria meningitidis.

  • Bacterial Septicemia

    Gramcef Injection 1 gm 1 Vial is used in the treatment of septicemia which is an infection of the blood caused by Staphylococci and Streptococcus pyogenes.

  • Intra-abdominal Infection

    Gramcef Injection 1 gm 1 Vial is used in the treatment of intra-abdominal infections caused by Helicobacter pylori, Staphylococci, and Streptococci.

  • Pneumonia

    Gramcef Injection 1 gm 1 Vial is used in the treatment of pneumonia which is a common type of lung infection caused by Streptococcus pneumoniae, and Haemophilus influenzae.

  • Bone and joint infections

    Gramcef Injection 1 gm 1 Vial is used in the treatment of bone and joint infections like septic arthritis and osteomyelitis caused by Staphylococci and Streptococci species.

  • Pyelonephriits

    Gramcef Injection 1 gm 1 Vial is used in the treatment of Pyelonephritis which is a type of kidney infection caused by E.coli, Pseudomonas aeruginosa, Enterococci and Klebsiella pneumoniae.

Concerns

Frequently asked questions

  • Onset of action

    The peak effect of this medicine can be observed in 1 hours for an intramuscular injection.

  • Duration of Effect

    The effect of this medicine lasts for an average duration of 3 to 6 hours.

  • Safe with Alchohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    No habit forming tendency has been reported.

  • Usage in pregnancy?

    Limited data is available on the use of Gramcef Injection 1 gm 1 Vial in pregnant women. Use only if clearly needed when benefits overweigh the risk.

  • Usage while breast-feeding?

    Small amounts of this medicine is excreted through human breast milk. Use only if clearly needed when benefits overweigh the risk. Monitoring of undesired effects like diarrhea and thrush is necessary.

When not to use?

  • Allergy

    Avoid if the patient has a known allergy toGramcef Injection 1 gm 1 Vial or any other Beta-lactam antibiotics like penicillins and cephalosporins.

Warnings

Warnings for special population
  • Pregnancy

    Limited data is available on the use of Gramcef Injection 1 gm 1 Vial in pregnant women. Use only if clearly needed when benefits overweigh the risk.

  • Breast-feeding

    Small amounts of this medicine is excreted through human breast milk. Use only if clearly needed when benefits overweigh the risk. Monitoring of undesired effects like diarrhea and thrush is necessary.

Warnings

Warnings for special population
  • Allergy

    Avoid if you have a known allergy to Gramcef Injection 1 gm 1 Vial or Beta-lactam Antibiotics like penicillins and cephalosporins. Seek immediate medical attention if the patient experiences any allergic symptoms like rash, itching, nausea, vomiting and swelling of lips, hands or feet.

  • Drug-resistance

    Usage of Gramcef Injection 1 gm 1 Vial without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that is drug resistant.

  • Clostridium difficile-associated Diarrhea

    Avoid if you experience severe diarrhea after receiving Gramcef Injection 1 gm 1 Vial . As antibiotic therapy will cause an imbalance in the normal microbial flora in the large intestine which promotes the growth of bacteria called clostridium difficile.

  • Impaired kidney function

    Use with caution if you have a preexisting kidney disease. Appropriate dose adjustments are to be made based of CrCl or eGFR.

  • Neurotoxicity

    Gramcef Injection 1 gm 1 Vial may increase the risk of serious adverse effects like encephalopathy, seizures, and nonconvulsive status epilepticus. These reactions may occur in the patient with impaired kidney function with no proper dose adjustment.

Dosage

  • Missed Dose

    The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

  • Overdose

    Seek emergency medical treatment or contact the doctor in case of overdose.

Interactions

Interaction with Medicines
  • Amikacin moderate
  • Ethinyl Estradiol moderate
  • Cholera Vaccine severe
  • Furosemide moderate
  • Cyclosporine moderate
Disease interactions
  • severe

    The blood concentration of intravenous Gramcef Injection 1 gm 1 Vial may increase in the patients suffering from any kidney disease. Suitable dose adjustments are to be made based on the severity of the condition. Frequent monitoring of kidney function tests is necessary.

  • moderate

    Avoid if you experience severe diarrhea, abdominal pain, and blood in stools after taking Gramcef Injection 1 gm 1 Vial . Inform the doctor if you have any gastrointestinal diseases. Drink adequate amount of water to prevent dehydration.

  • moderate

    Use with caution if you have any seizure disorder or a family history of seizures. Appropriate dose adjustments are to be made if you have a kidney disease. Discontinue if seizure is due to Gramcef Injection 1 gm 1 Vial . Start with appropriate anticonvulsant medicine if it is clinically indicated.

Lab interactions

General Instructions

Make sure that the medicine is dissolved properly. Do not take if any particulate matter is visible. Consult the doctor if you experience any undesirable effects. Do not stop taking before completion of course.

Other details

  • Can be taken with or without food, as advised by your doctor
  • To be taken as instructed by doctor
  • May cause sleepiness

References

How to use Gramcef Injection 1 gm 1 Vial

IM: Inject deep IM into large mass muscle. IV: Ceftazidime can be administered IVP over 3-5 min or IV intermittent infusion over 15-30 min; final concentration for IV administration should not exceed 100 mg/ mL. Rotate IV sites every 72 hours. Assess for phlebitis and extravasation.
Reconstitution: IV: For IV bolus, reconstitute 1-2 gm with 10 mL SWFI, D5W, or NaCl. Shake to dissolve. For intermittent infusion, further dilute in 50-100 mL D5W or NS. IM: Reconstitute each gm with 3 mL SWFI or bacteriostatic water for injection.
Compatibility: D5NS, D5W, NS, SWFI.
Stability: For reconstituted solution and IV infusion in NS or D5W solution is stable for 24 hours at room temperature, 10 days when refrigerated, or 12 weeks when frozen.

what are the adverse effects of Gramcef Injection 1 gm 1 Vial

Pain at inj site, hypersensitivity reactions. Gl disturbances, candidiasis, eosinophilia, neutropenia, leucopenia, thrombocytopenia, rise in liver enzymes and blood urea. Positive Coomb’s test, phlebitis or thrombophlebitis, thrombocytosis, pseudomembranous colitis, haemolytic anaemia.

What is the dose of Gramcef Injection 1 gm 1 Vial

Adults: 1-6 gm/day in 2 or 3 divided doses by IV or IM inj. Children: Above 2 mth, 30-100 mg/kg/day in 2 or 3 divided doses; under 2 mth, 25-60 mg/kg/day in 2 divided doses.
Bone Infection: IV: Adults: 2 gm every 12 hr. Children: 1 mth-12 yr: 30-50 mg/kg every 8 hr, up to 6 gm/day. 0-4 wk: 30 mg/kg every 12 hr.
Meningitis: IV: Adults: 2 gm every 8 hr. Children: 1 mth-12 yr: 30-50 mg/kg every 8 hr, up to 6 gm/day. 0-4 wk: 30 mg/kg every 12 hr.
Septicaemia: IV: Adults: 2 gm every 8 hr. Children: 1 mth-12 yr: 30-50 mg/kg every 8 hr, up to 6 gm/day. 0-4 wk: 30 mg/kg every 12 hr.

One of the following licensed pharmacy from the nearest location will deliver Gramcef Injection 1 gm 1 Vial. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts the your request based on valid prescription and availability.

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