₨ 4,540.82
MBBS
Granocyte 34 Injection 1 Amp
- Does this requires a prescription ? Yes
- Generic Name: Lenograstim
- Manufactured by : Sanofi-aventis
- Drug Form : 34 Injection
- Pack Size : 1 AMP
- Product SKU : pg_10291_14358
Granocyte 34 Injection contains Lenograstim | belongs to Recombinant G-CSF (Recombinant human granulocyte-colony stimulating factor)
How it works
Granocyte 34 Injection 1 Amp works by stimulating the production of white blood cells and thus helps to fight against infections.
Side effects
Major & minor side effects for Granocyte 34 Injection 1 Amp
- Nausea and Vomiting rare
- Diarrhea rare
- Stomach pain rare
- Constipation rare
- Fever
- Tiredness rare
- Chest pain rare
- Muscle pain
- Back pain rare
- Headache
- Dizziness rare
- Shortness of breath rare
- Cough rare
Uses of Granocyte 34 Injection 1 Amp
What is it prescribed for?
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Neutropenia caused by chemotherapy
This medicine is used to reduce the incidence of infection in patients receiving myelosuppressive anti-cancer drugs.
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Bone Marrow Transplantation
This medicine is used to treat febrile neutropenia, the fever caused due to decreased neutrophil count in patients receiving chemotherapy followed by bone marrow transplantation.
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Peripheral Progenitor Cell Transplantation
This medicine is used before the procedure of leukapheresis to mobilize the autologus hematopoietic progenitor cells into the peripheral blood for collection.
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Severe congenital neutropenia
This medicine is used in the treatment of severe congenital neutropenia (SCN), a condition characterized by a deficiency of a type of white blood cell called neutrophils.
Concerns
Frequently asked questions
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Onset of action
The amount of time required for this medicine to show its action is not clinically established.
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Duration of Effect
The amount of time for which this medicine remains active in the body is not clinically established.
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Safe with Alchohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
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Is it habit forming?
No habit forming tendency has been reported.
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Usage in pregnancy?
This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
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Usage while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
When not to use?
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Allergy
This medicine is not recommended for use in patients with a known allergy to Granocyte 34 Injection 1 Amp or other inactive ingredients present along with it.
Warnings
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Pregnancy
This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
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Breast-feeding
This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
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Liver Diseases
This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
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Kidney Diseases
This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
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Infections
This medicine should be used with extreme caution in patients with latent or active infections since it may worsen the patient's condition. This risk is especially higher in patients on high doses of this medicine for a prolonged period of time. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.
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Sickle cell crisis
This medicine should be used with extreme caution in patients with sickle cell disease due to the increased risk of serious and life-threatening reactions. Discuss the risks and benefits with your doctor before receiving this medicine. Replacement with a suitable alternative might be required based on the clinical condition.
Dosage
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Missed Dose
Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low.
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Overdose
Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
General Instructions
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Your dose regimen and frequency of administration is likely to vary based on the condition being treated. Consult your doctor immediately if you develop any signs and symptoms of an infection.
Other details
- Usage does not depend on food timings
- To be taken as instructed by doctor
- Does not cause sleepiness
References
- drugbank - Lenograstim [Internet]. Available from: https://go.drugbank.com/drugs/DB13144 [cited 2/16/2021]. 2021
How to use Granocyte 34 Injection 1 Amp
Intermittent in NS: Initially reconstitute with 1 mL WFI provided (do not shake vigorously) then dilute with up to 50 mL+AE372 infusion fluid for each vial of 105 mcg or up to 100 mL infusion fluid for 263 mcg, give over 30 min.
UNLICENSED USE
Children: Following peripheral stem cells or bone-marrow transplantation: IV infusion over 30 minutes or SC injection. 2-18 yr, 150 mcg/m2 daily started the day after transplantation, continued until neutrophil count stable in acceptable range (max 28 days).
Cytotoxic-induced neutropenia: SC injection. 2-18 yr, 150 mcg/m2 daily started the day after completion of chemotherapy, continued until neutrophil count stable in acceptable range (max 28 days).
Mobilisation of peripheral blood progenitor cells, used alone: SC injection. 2-18 yr, 10 mcg/kg daily for 4-6 days (5-6 days in healthy donors).
Mobilisation of peripheral blood progenitor cells following adjunctive myelosuppressive chemotherapy (to improve yield): SC injection. 2-18 yr, 150 mcg/m2 daily, started 1-5 days after completion of chemotherapy and continued until neutrophil count in acceptable range; for timing of leucopheresis consult product literature.
what are the adverse effects of Granocyte 34 Injection 1 Amp?
Musculoskeletal pain, transient hypotension, disturbances in liver enzymes and serum uric acid; thrombocytopenia; urinary abnormalities including dysuria; allergic reactions (more common after intravenous infusion), proteinuria, haematuria and transient decrease in blood glucose; on long-term use cutaneous vasculitis, splenic enlargement, hepatomegaly, headache, diarrhoea, anaemia, epistaxis, alopecia, osteoporosis, rash, raised lactate dehydrogenase, leucocytosis, asthaenia, bone pain, back pain, abdominal pain, inj site reaction, capillary leak syndrome, pulmonary adverse effects, aortitis.
What happens if I miss a dose of Granocyte 34 Injection 1 Amp?
Following bone-marrow transplantation: By IV infusion. Adults & Children over 2 yr: 19.2 million units/m² daily started the day after transplantation, continued until neutrophil count stable in acceptable range (max 28 days).
Cytotoxic induced neutropenia: By SC injection. Adults & Children over 2 yr: 19.2 million units/m² daily, started the day after completion of chemotherapy, continued until neutrophil count stable in acceptable range (max 28 days).
One of the following licensed pharmacy from the nearest location will deliver Granocyte 34 Injection 1 Amp. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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