Hydralazine Injection 20 mg 1 Amp

How to use Hydralazine Injection 20 mg 1 Amp

Inject over 1 min. Hypotensive effect may be delayed and unpredictable in some patients.
Reconstitution: Hydralazine should be diluted in NS for IVPB administration due to decreased stability in D5W. Stability of IVPB solution in NS is 4 days at room temperature.
Compatibility: Stable in NS, D5NS, D10W, D5LR, 1/2NS, LR. Incompatible with D5W. At Y-site administration, incompatible with aminophylline, ampicillin, diazoxide, furosemide. When admixed, incompatible with aminophylline, ampicillin, chlorothiazide, edetate calcium disodium, ethacrynate, hydrocortisone sodium succinate, mephentermine, methohexital, nitroglycerin, phenobarbital, verapamil.
Stability: Intact ampoules/vials should not be stored under refrigeration because of possible precipitation or crystallization.

UNLICENSED USE
Children: Hypertension: ORAL: Neonate, 250-500 mcg/kg every 8-12 hr increased as necessary to max 2-3 mg/kg every 8 hr; 1 mth-12 yr, 250-500 mcg/kg every 8-12 hr increased as necessary to max 7.5 mg/kg daily (not exceeding 200 mg daily); 12-18 yr, 25 mg twice daily, increased to usual max 50-100 mg twice daily.
INJECTION: Slow IV injection. Neonate, 100-500 mcg/kg repeated every 4-6 hr as necessary; max 3 mg/kg daily; 1 mth-12 yr, 100-500 mcg/kg repeated every 4-6 hr as necessary; max 3 mg/kg daily (not exceeding 60 mg daily); 12-18 yr, 5-10 mg repeated every 4-6 hr as necessary. Continuous IV infusion (preferred route in cardiac patients). Neonate, 12.5-50 mcg/kg/hr; max 2 mg/kg daily; 1 mth-12 yr, 12.5-50 mcg/kg/hr; max 3 mg/kg daily; 12-18 yr, 3-9 mg/hr; max 3 mg/kg daily.

what are the adverse effects of Hydralazine Injection 20 mg 1 Amp?

Tachycardia, palpitation, flushing, hypotension, angina, fluid retention, gastro-intestinal disturbances; headache, dizziness; systemic lupus erythematosus-like syndrome after long-term therapy with over 100 mg daily (or less in women and in slow acetylator individuals); rarely rashes, fever, dyscrasias, peripheral neuritis, polyneuritis, paraesthesia, arthralgia, myalgia, increased lacrimation, nasal congestion, dyspnoea, agitation, anxiety, anorexia; blood disorders (including leucopenia, thrombocytopenia, haemolytic anaemia), abnormal liver function, jaundice, raised plasma creatinine, proteinuria and haematuria reported.

What happens if I miss a dose of Hydralazine Injection 20 mg 1 Amp?

Adults: ORAL: Hypertension: 25 mg twice daily, increased to usual max 50 mg twice daily. Heart failure: (Initiated in hospital) 25 mg 3-4 times daily, increased every 2 days if necessary; usual maintenance dose 50-75 mg 4 times daily. INJECTION: Hypertensive emergencies and hypertension with renal complications: By slow IV inj, 5-10 mg diluted with 10 mL sodium chloride 0.9%; may be repeated after 20-30 min. By IV infusion, initially 200-300 mcg/min; maintenance usually 50-150 mcg/min.
Children: Not recommended.

One of the following licensed pharmacy from the nearest location will deliver Hydralazine Injection 20 mg 1 Amp. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.