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How it works
Ibnate Injection 1 mg 1 Amp are taken into the bone where they bind to hydroxyapatite. Bone resorption by osteoclasts causes local acidification, releasing the bisphosphonate, which is taken into the osteoclast by fluid-phase endocytosis.5 Endocytic vesicles become acidified, releasing bisphosphonates into the cytosol of osteoclasts where they act.5
Concerns
Frequently asked questions
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Onset of action
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Duration of Effect
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Safe with Alchohol?
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Is it habit forming?
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Usage in pregnancy?
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Usage while breast-feeding?
Dosage
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Missed Dose
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Overdose
References
- drugbank.ca - Ibandronate [Internet]. Available from: https://www.drugbank.ca/drugs/DB00710 [cited 3/7/2020]. 2020
- patient.info - Ibandronate [Internet]. Available from: https://patient.info/medicine/ibandronic-acid-tablets-and-injection-bondronat-iasibon-bonviva-quodixor [cited 3/7/2020]. 2019
IV: Administer as a 15-30 seconds bolus. Do not mix with calcium containing solution or other drugs. For osteoporosis, do not administer more frequently than every three months. Infuse over 1 hour for metastatic bone diseases due to breast cancer and over 1-2 hours for hypercalcaemia of malignancy.Additional Information
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How to use Ibnate Injection 1 mg 1 Amp
Stability: Store at controlled room temperature of 25°C; excursions permitted to 15°C-30°C.
what are the adverse effects of Ibnate Injection 1 mg 1 Amp?
In patients treated for hypercalcaemia, rise in body temperature, flu-like syndrome, hypocalcaemia. In patients with metastatic bone disease, headache, diarrhoea, myalgia, asthaenia, flu-like illness, abdominal pain, dyspepsia, vomiting.
What happens if I miss a dose of Ibnate Injection 1 mg 1 Amp?
INJECTION: Reduction of bone damages in metastases in breast cancer: Adults: 6 mg IV every 3-4 wk, added to 500 mL isotonic NaCl soln (or 5% dextrose soln) and infused over 1 hr.
Hypercalcaemia: Adults: Patients should be adequately rehydrated with 0.9% NaCl. Single infusion of 2-4 mg, added to same soln. as above and infused over 2 hr based on the severity of hypercalcaemia and tumour type.
Treatment of post-menopausal osteoporosis: Adults: IV injection over 15-30 sec, 3 mg every 3 mth.
ORAL: Reduction of bone damages in metastases in breast cancer: Adults: 50 mg once daily.
Treatment of post-menopausal osteoporosis to reduce risk of fractures: Adults: 150 mg once a mth.
Children: Not recommended.
One of the following licensed pharmacy from the nearest location will deliver Ibnate Injection 1 mg 1 Amp. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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