
MBBS
Imfinzi 120mg/2.4mlDurvalumab injection
How it Works
Imfinzi (durvalumab) is a monoclonal antibody used in cancer immunotherapy. It targets and binds to the programmed death-ligand 1 (PD-L1) protein found on the surface of cancer cells and some immune cells. PD-L1 interacts with the programmed death-1 (PD-1) receptor on T-cells (a type of immune cell), leading to the inhibition of the T-cells’ ability to attack cancer cells. By blocking the PD-L1/PD-1 interaction, durvalumab reactivates T-cells, enabling them to recognize and destroy cancer cells. This mechanism of action helps enhance the body’s immune response against tumors, particularly in certain types of cancers.
Side Effects
- Fatigue
- Nausea
- Diarrhea
- Decreased appetite
- Rash
- Constipation
- Arthralgia (joint pain)
- Cough
- Infections
- Shortness of breath
- Abdominal pain
- Fever
- Elevated liver enzymes
Indications
- Unresectable stage III non-small cell lung cancer (NSCLC) that has not progressed following concurrent platinum-based chemotherapy and radiation therapy
- Extensive-stage small cell lung cancer (ES-SCLC) in combination with chemotherapy
- Locally advanced or metastatic urothelial carcinoma in patients who have disease progression during or following platinum-containing chemotherapy
Contraindications
- Hypersensitivity to durvalumab or any of its excipients
- Patients with active or history of autoimmune diseases requiring systemic treatment
- Severe or life-threatening infusion-related reactions
- Severe immune-mediated adverse reactions (e.g., pneumonitis, hepatitis, colitis)
- Pregnancy and breastfeeding (use with caution and only if clearly needed)
Price Comparison in Different Countries
Country | Price (USD) | Website |
---|---|---|
United States | $9,200 | GoodRx |
Canada | $7,800 | PharmacyChecker |
United Kingdom | £6,500 | NHS |
Australia | AUD 11,000 | PBS |
India | ₹700,000 | Medindia |
Top 5 Global Brands
- Imfinzi (AstraZeneca)
- Keytruda (Merck & Co.)
- Opdivo (Bristol-Myers Squibb)
- Tecentriq (Genentech/Roche)
- Bavencio (EMD Serono/Pfizer)
One of the following licensed pharmacy from the nearest location will deliver Imfinzi 120mg/2.4mlDurvalumab injection. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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