Irinotel Injection 40 mg 1 Vial

How to use Irinotel Injection 40 mg 1 Vial

IV: Administer by IV Infusion, usually over 90 min. D5W (500 mL) is the preferred diluent for most doses. Solutions diluted in NS may precipitate if refrigerated.
Reconstitution: Dilute in D5W or NS to a final conc of 0.12-2.8 mg/mL. Due to the relatively acidic pH, irinotecan appears to be more stable in D5W than NS, D5W (500 mL) is the preferred diluent for most doses.
Compatibility: Stable in D5W, NS.
Stability: Store vials at 15°C-30°C (59°F-86°F). Protect from light. Vials should remain in carton until the time of use. The diluted solution is physically and chemically stable for up to 24 hours at room temperature (approximately 25°C) and in ambient fluorescent lighting. In the case of admixtures prepared with D5W or NaCl, the solutions should be used within 6 hours if kept at room temperature 15°C-30°C (59°F-86°F). Solutions diluted in D5W and stored at refrigerated temperatures 2°C-8°C (36°F-46°F) and protected from light are physically and chemically stable for 48 hours; however it is advisable to use them within 24 hours. Refrigeration of admixtures using 0.9% NaCl is not recommended.

what are the adverse effects of Irinotel Injection 40 mg 1 Vial?

Delayed diarrhoea, warn patient of risk and start high dose loperamide immediately. Neutropenia, monitor neutrophil count, instruct patient to report fever. Anaemia, thrombocytopenia. Liver impairment; perform liver function tests. Nausea, vomiting, acute cholinergic syndrome, asthaenia, alopecia, dyspnoea, cramps, paraesthesia.

What happens if I miss a dose of Irinotel Injection 40 mg 1 Vial?

Adults: 350 mg/m² by IV infusion over 30-90 min every 3 wk. If patient develops severe neutropenia or severe diarrhoea reduce dose to 300 mg/m² and then 250 mg/m² in subsequent cycles. Continue treatment until disease progression or unacceptable toxicity. Children: Not recommended.

One of the following licensed pharmacy from the nearest location will deliver Irinotel Injection 40 mg 1 Vial. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.