Jevtana Infusion 60 mg 1 Vialx1.5 mL

How to use Jevtana Infusion 60 mg 1 Vialx1.5 mL

IV as a 1 hour infusion at room temperature.
Initial dilution: Each vial of Cabazitaxel 60 mg per 1.5 mL must first be mixed with the entire contents of supplied diluent to get the concentration of 10 mg/mL. This dilution requires further dilution before administration and it should be done within 30 min.
Final dilution: Withdraw the recommended dose from the 10 mg/mL and further dilute into a sterile 250 mL PVC free container of NaCl 0.9% solution or dextrose 5% solution for infusion. If a dose greater than 65 mg is required, use a larger volume of the infusion vehicle so that a concentration of 0.26 mg/mL is not exceeded. The concentration of the final dilution should be between 0.1 and 0.26 mg/mL.
Stability: Cabazitaxel final dilution should be used immediately or within 8 hours at ambient temperature or within a total of 24 hours if refrigerated. Because the final dilution of infusion solution is supersaturated, it may crystallize over time. Do not use and discard if this occurs.

what are the adverse effects of Jevtana Infusion 60 mg 1 Vialx1.5 mL?

Infections, blood dyscrasias, anorexia, dehydration, hyperglycaemia, hypokalaemia, anxiety, confusion, dysgeusia, peripheral neuropathy, dizziness, headache, paraesthesia, fatigue, hypoesthesia, increased lacrimation, tinnitus, vertigo, arrhythmias, blood pressure changes, DVT, hot flushes, flushing, dyspnoea, cough, oropharyngeal pain, GI upset, haemorrhoids, rectal haemorrhage, dry mouth, alopecia, dry skin, erythema, musculoskeletal pain, muscle spasm, flank pain, renal failure, dysuria, renal colic, haematuria, pollakiuria, hydronephrosis, urinary retention ad incontinence, ureteric obstruction, pelvic pain, asthaenia, fever, oedema, mucosal inflammation, chest pain, chills, weight loss, raised liver enzymes.

What happens if I miss a dose of Jevtana Infusion 60 mg 1 Vialx1.5 mL?

Adults: 25 mg/m² by IV inf over 1 hr every 3 wk, with daily prednisolone. Premedicate with an antihistamine, corticosteroid and H2 antagonist gt;30 min before each inf. Children: Not applicable.

One of the following licensed pharmacy from the nearest location will deliver Jevtana Infusion 60 mg 1 Vialx1.5 mL. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.