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Kinzole tablet 40 mg 14's

Kinzole tablet contains Pantoprazole | belongs to Proton pump inhibitor

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How it works

Kinzole tablet 40 mg 14’s works by interfering with the final step of acid release in the stomach. This helps in reducing the acidity in the stomach.

Side effects

Major & minor side effects for Kinzole tablet 40 mg 14’s

  • Headache
  • Altered sense of taste
  • Runny Nose and Cough
  • Diarrhea
  • Nausea or Vomiting
  • Unusual tiredness and weakness
  • Skin Rash severe
  • Anorexia
  • Injection site Thrombophlebitis

Uses of Kinzole tablet 40 mg 14’s

What is it prescribed for?

  • Erosive Esophagitis

    Kinzole tablet 40 mg 14’s is used in the treatment of inflammation and severe ulcers of the esophagus caused by chronic acidity.

  • Gastroesophagal Reflux Disease

    Kinzole tablet 40 mg 14’s is used in the treatment of reflux disease, where acid from the stomach enters and irritates the food pipe (esophagus).

  • Helicobacter pylori Infection

    Kinzole tablet 40 mg 14’s is used to treat Helicobacter Pylori infection in combination with other drugs.

  • Zollinger-Ellison Syndrome

    Kinzole tablet 40 mg 14’s is used to treat a condition where an excessive amount of acid is produced in the stomach due to tumors in the small intestines.

  • Gastro-duodenal ulcers

    Kinzole tablet 40 mg 14’s is used to treat ulcers in the stomach (gastric) and small intestines (duodenal). It is also used to prevent ulcers caused due to stress.

Concerns

Frequently asked questions

  • Onset of action

    Kinzole tablet 40 mg 14’s is rapidly absorbed from the gastro-intestinal tract and reaches its peak levels after 2 to 2.5 hours of oral administration.

  • Duration of Effect

    Kinzole tablet 40 mg 14’s remains active in the body for up to 24 hours after the administration of the dose.

  • Safe with Alchohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Usage in pregnancy?

    No habit-forming tendencies were reported.

  • Usage while breast-feeding?

    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

When not to use?

  • Allergy

    This medicine is not recommended for use in patients with a known allergy to Kinzole tablet 40 mg 14’s or any other drug of the same group, i.e. Benzimidazoles.

Warnings

Warnings for special population
  • Pregnancy

    This medicine is considered safe for consumption by pregnant women. However, discuss all the risks and benefits with your doctor before using this medicine.

  • Breast-feeding

    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Warnings

Warnings for special population
  • Allergic Reactions

    This medicine is not recommended for use in patients with a known allergy to Pantoprazole or any other drug of the same group, i.e. benzimidazoles since it may cause severe allergic reactions. This risk is especially higher if the drug is administered intravenously.

  • Heartburn

    Kinzole tablet 40 mg 14’s does not give instant relief from heartburn. Hence, it is not effective in treating acute heartburn symptoms.

  • Liver Disease

    Kinzole tablet 40 mg 14’s should be used with caution in patients with active liver diseases or a history of liver diseases due to the increased risk of serious adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

  • Bone Fractures

    Use of high doses of Kinzole tablet 40 mg 14’s for a prolonged duration may increase the risk of bone fractures. This risk is especially higher in the elderly population and in women. Appropriate calcium and vitamin D supplementation may be required in some cases to reduce this risk.

  • Vitamin B-12 Deficiency

    Long-term treatment with Kinzole tablet 40 mg 14’s may decrease the absorption of Vitamin B12 in the body. This may cause vitamin B12 deficiency and associated symptoms. Appropriate vitamin B12 supplementation may be necessary based on the clinical condition.

Dosage

  • Missed Dose

    Oral forms: The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already the time for your next scheduled dose. Injection: Since Pantoprazole injection is usually administered by a qualified healthcare professional in a clinical setting, the likelihood of missing a dose is very low.

  • Overdose

    Oral forms: Seek emergency medical treatment or contact your doctor in case of an overdose. Injection: Since this medicine is usually administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.

Interactions

Interaction with Medicines
  • Ketoconazole moderate
  • Methotrexate severe
  • Warfarin moderate
  • Nelfinavir severe
  • Digoxin moderate
Disease interactions
  • moderate

    Kinzole tablet 40 mg 14’s should be used with caution in patients with a history of liver diseases or active liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

  • moderate

    Kinzole tablet 40 mg 14’s should be used with extreme caution in patients with a history of osteoporosis due to the increased risk of fractures. This risk is especially higher with a high dose and prolonged use. Appropriate dose adjustments, clinical monitoring, or replacement with a suitable alternative may be required based on the clinical condition.

  • moderate

    Kinzole tablet 40 mg 14’s should be used with caution in patients who are prone to magnesium imbalances since it increases the risk of low magnesium levels. Report any unusual symptoms to the doctor immediately. Regular monitoring of magnesium levels, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Lab interactions

General Instructions

Oral forms: Take Kinzole tablet 40 mg 14’s with or without food. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor. Injection: Pantoprazole should be administered by a qualified healthcare professional for the prescribed duration only after a test dose. Report any unusual symptoms to the doctor immediately.

Other details

  • Can be taken with or without food, as advised by your doctor
  • To be taken as instructed by doctor
  • Does not cause sleepiness

References

How to use Kinzole tablet 40 mg 14’s

IV: Infuse over 15 min at a rate not to exceed 3 mg/min. Use in-line filter (positioned below Y-site if use). Flush IV line with D5W, NS, or lactated Ringer’s injection before and after giving drug.
Reconstitution: Reconstitute each 40 mg vial with 10 mL 0.9% NaCl and dilute with 100 mL infusion fluid, give 40 mg over 15 min. Use within 12 hrs.
Compatibility: Intermittent infusion in 5% Glucose or 0.9% NaCl.
Y-site administration:
Drug to Drug IV Compatibility: Azithromycin, bumetanide, ceftriaxone, imipenem, phenylephrine, vasopressin.
Drug to Drug IV Incompatibility: Aztreonam, cefepime, ciprofloxacin, dexamethasone, diltiazem, diphenhydramine, dobutamine, esmolol, famotidine, fentanyl, fluconazole, labetalol, levofloxacin, linezolid, lorazepam, methylprednisolone, metronidazole, midazolam, ondansetron.
Stability: Store at 2°C-8°C. Solution may be stored up to 2 hours before further dilution and up to 22 hours before use.

what are the adverse effects of Kinzole tablet 40 mg 14’s

Nausea, headache, diarrhoea, constipation, skin rashes, fundic gland polyps. Report of subacute cutaneous lupus erythematosus.

What is the dose of Kinzole tablet 40 mg 14’s

ORAL: Adults: Duodenal ulcer: 40 mg daily in the morning for 2 wk. Extend for a further 2 wk if not healed.
Gastric ulcer: 40 mg daily in the morning for 4 wk. Extend for a further 4 wk if not healed.
NSAID ulceration: 20 mg daily.
Zollinger-Ellison syndrome: Initially 80 mg daily, adjust dose according to gastric acid secretion.
GERD: 20-40 mg daily in the morning for 2-4 wk. Extend for a further 4 wk if not healed. Maintenance, 20 mg daily; reassess risk/benefit if treatment exceeds 1 yr.
Control of recurring symptoms in healed reflux disease: 20 mg once daily when required.
Triple therapy vs H. Pylori: 40 mg twice daily with either clarithromycin 250 mg and metronidazole 400 mg both twice daily for one wk or clarithromycin 500 mg and amoxicillin 1 gm both twice daily for one wk.
Children: Not recommended.
INJECTION: Adults: Duodenal ulcer, gastric ulcer, reflux oesophagitis: IV: 1 vial/day.
Long-term management of Zollinger-Ellison syndrome & other pathological hypersecretory conditions: IV: Initially 80 mg/day. Thereafter, dosage can be titrated up or down as needed using measurements of gastric acid secretion as guide. For rapid acid control: Initially 2 x 80 mg IV to manage a decrease in acid output (lt;10 mEq/hr) within one hr. As soon as oral therapy is possible discontinue IV treatment.
Children: Not recommended.

One of the following licensed pharmacy from the nearest location will deliver Kinzole tablet 40 mg 14’s. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts the your request based on valid prescription and availability.

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