Mannitol 20.00% Infusion 500 ml

Mannitol 20.00% Infusion 500 ml is a polyol (sugar alcohol) with a low molecular weight that is filtered at the glomerulus but not reabsorbed from the renal tubule. It exerts osmotic activity within the proximal convoluted tubule and the descending limb of the loop of Henle, which limits passive tubular reabsorption of water.

Side effects

Major & minor side effects for Mannitol 20.00% Infusion 500 ml

• Headache
• Dry mouth
• Dehydration
• Fluid and electrolyte imblance severe
• Chest pain
• Dizziness
• Blurred vision severe
• Nausea
• Fast or irregular heartbeat rare
• Reduced food intake rare
• Uncontrolled shaking of arms or legs rare
• Urinary incontinence rare

Uses of Mannitol 20.00% Infusion 500 ml

What is it prescribed for?

• Cerebral edema (Fluid accumulation in cerebral cavity)

  This medicine is used to reduce cerebral edema (brain swelling) by decreasing the intracranial pressure.

• Oliguria (Low urine output)

  Manilup 20 % Infusion is used to treat oliguria by increasing the urine output.

• Intraocular pressure (Fluid pressure inside the eye)

  This medicine is used to decrease the fluid pressure inside the eye (intraocular pressure).

When not to use?

• Volume and electrolyte depletion

  Manilup 20 % Infusion may alter the blood volume levels and electrolyte levels. This may cause dizziness, dry mouth, and acid-base imbalance. Close monitoring of blood pressure and electrolytes levels is necessary while taking this medicine. Report any symptoms such as weakness, lethargy, muscle pain, drowsiness, dizziness, irregular heartbeat, etc. to the doctor immediately.

• Allergy

  This medicine is not recommended for use in patients with a known allergy to Manilup 20 % Infusion.

• Crystallization of solutions

  This medicine may crystallize when exposed to low temperatures. If crystals are visible, they can be dissolved by warming the solution in a hot water bath or a warming cabinet, followed by gentle agitation (shaking of the vial). Once crystals dissolve, allow the solution to cool to room temperature, reinspect for crystals, and use if crystals are not visible. The medicine should not be used if crystals are present. Please note that the method of warming may differ based on the manufacturer's recommendations.

Manilup 20 % Infusion will be administered by your doctor or a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have an allergy to this medicine. Report all your current medicines as well as your medical history to the doctor. This medicine is usually given at daytime to prevent sleep disturbance. Drink an adequate amount of water. Monitoring of kidney function and electrolytes levels is necessary during treatment with this medicine. This medicine should be used with caution due to the increased risk of dizziness.

• Usage does not depend on food timings
• To be taken as instructed by doctor
• Does not cause sleepiness

• rxlist.com - Mannitol [Internet]. Available from: https://www.rxlist.com/consumer_mannitol_osmitrol/drugs-condition.htm [cited 7/7/2020].
• sciencedirect.com - Mannitol [Internet]. Available from: https://www.sciencedirect.com/topics/neuroscience/mannitol#:~:text=Mannitol%20is%20a%20polyol%20(sugar,passive%20tubular%20reabsorption%20of%20water. [cited 7/7/2020].