METOTREXATO 500mg Injection Vial

Frequently asked questions

• Onset of action

  The effect of this medicine can be observed in 1 to 2 hours after an oral dose and 30 to 60 minutes after an intramuscular injection.

• Duration of Effect

  The effect of this medicine lasts for an average duration of 9 to 30 hours at a low dose and 24 to 45 hours at a high dose.

• Safe with Alchohol?

  Consumption of alcohol is not recommended due to the risk of liver injury. Close monitoring of liver enzymes is necessary. Seek immediate medical treatment if any symptoms like lethargy, yellow colored eyes, and skin, abdominal pain appear.

• Is it habit forming?

  No habit forming tendencies were reported.

• Usage in pregnancy?

  This medicine is not recommended for pregnant women.

• Usage while breast-feeding?

  This medicine is not recommended in breastfeeding women.

• Allergy

  Not recommended in patients with known allergy to METOTREXATO 500mg Injection Vial .

• Pregnancy

  Not recommended for pregnant women due to the risk of birth defects.

• Liver disease

  Not recommended in patients with the existing liver disease.

• Blood disorder

  Not recommended in patients with existing blood diseases.

• Pregnancy

  This medicine is not recommended for pregnant women.

• Breast-feeding

  This medicine is not recommended in breastfeeding women.

• Liver injury

  This medicine is not recommended in the patients with the liver injury. The concentration of this medicine may increase in these patients. The baseline of the liver function tests should be obtained before starting the treatment.

• Kidney injury

  This medicine is not recommended in the patients with the kidney injury. It may cause kidney injury at higher doses. The dose of this medicine should be adjusted based on the CrCl.

• Lung toxicity

  This medicine may cause severe lung injuries like pulmonary fibrosis, pulmonary interstitial infiltrates. Any symptoms of breathing difficulty and signs of lung impairment should be informed to the doctor. The treatment should be discontinued if any symptoms appear.

• Blood cell count

  This medicine may lower the white blood cell count (neutrophils) and platelets. Close monitoring of blood cell count is necessary. The baseline of the blood cell count should be obtained before initiation of the treatment. Do not start the treatment if the counts are less.

• Skin reactions

  The medicine may cause severe skin reactions stevens-johnson syndrome, skin necrosis, and skin ulceration. Inform the doctor if any symptoms appear. The treatment should be discontinued.

• Gastrointestinal injury

  This medicine is not recommended for use in patients with gastrointestinal disorders like diarrhea and ulcerative stomatitis. Inform the doctor if you have any gastrointestinal disorders before initiation of the therapy.

• Infections

  The chances of occurring infections are more in the patients receiving this medicine. Hold the chemotherapy and start with the broad-spectrum antibiotics if there are any signs and symptoms of fever. Close monitoring of the body temperature and the blood cell count is necessary.

Take METOTREXATO 500mg Injection Vial as instructed by your doctor. Do not take in larger amounts than advised. Do not miss any scheduled dose. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine without consulting your doctor.

• Can be taken with or without food, as advised by your doctor
• To be taken as instructed by doctor
• May cause sleepiness

• practo.com - Methotrexate [Internet]. Available from: https://www.practo.com/medicine-info/methotrexate-177-api [cited 7 october 2019]. 16 Nov 2017
• medlineplus.gov - Methotrexate [Internet]. Available from: https://medlineplus.gov/druginfo/meds/a682019.html [cited 7 october 2019]. 4/15/2017
• dailymed.nlm.nih.gov - METHOTREXATE [Internet]. Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ec476b11-0b3c-4139-b1eb-a3daa76bc271#a15d5648-439e-4a6d-b23d-1c02c0329aff [cited 7 october 2019]. April 1, 2016