Norepine Injection 2 mg 10 Amp

 3,000.00

Manufactured by:
Active Pharmaceutical Ingredient:
Drug Strength: 2 mg
Drug Form : Injection
Pack Size : 10 AMP
Does this requires a prescription ?Yes

Norepine Injection contains Norepinephrine | belongs to Vasoconstrictor sympathomimetic

SKU: pg_16318_22626 Categories: ,

Alternate brands

  • Norepinephrine Injection 2 mg 1 Ampx2 mL
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    How it works

    [pst_title] works by narrowing the blood vessels in order to increase blood pressure. It also increases heart rate.

    Side effects

    Major & minor side effects for Norepine Injection 2 mg 10 Amp

    • Headache
    • High blood pressure
    • Difficulty in breathing
    • Increased sweating rare
    • Nausea and vomiting rare
    • Unusual tiredness or weakness
    • Loss of appetite

    Uses of Norepine Injection 2 mg 10 Amp

    What is it prescribed for?

    • Hypotension

      This medicine is used to restore the blood pressure in low blood pressure states often associated with certain medical conditions or surgical procedures.

    • Cardiac arrest

      This medicine is used as an adjunct in the treatment of heart attack (cardiac arrest).

    • Sepsis or Septic shock

      This medicine is used to raise the mean arterial blood pressure in patients during sepsis or septic shock

    Concerns

    Frequently asked questions

    • Onset of action

      The effect of this medicine can be observed within 1 to 2 minutes of administration of the dose.

    • Duration of Effect

      The amount of time for which this medicine remains active in the body is not clinically established.

    • Safe with Alchohol?

      Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

    • Is it habit forming?

      No habit-forming tendencies were reported.

    • Usage in pregnancy?

      This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

    • Usage while breast-feeding?

      This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

    When not to use?

    • Allergy

      This medicine is not recommended for use if you have a known allergy to Norepine Injection 2 mg 10 Amp or any other inactive ingredients present along with it.

    • Hypotension due to hypovolemia

      This medicine is not recommended to treat low blood pressure state resulting from blood volume deficit (hypovolemia).

    • Peripheral vascular thrombosis

      This medicine is not recommended for use in patients with peripheral vascular thrombosis unless in lifesaving procedures.

    Warnings

    Warnings for special population
    • Pregnancy

      This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

    • Breast-feeding

      This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

    General Warnings
    • Heart rhythm disorders

      This medicine should be used with caution in patients with heart rhythm disorders due to the increased risk of severe adverse effects. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

    • Hypertension

      This medicine may increase the blood pressure levels in some patients during therapy. Close monitoring of blood pressure levels is necessary while receiving this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

    • Kidney impairment

      This medicine should be used with caution in patients with a history of kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

    • Liver impairment

      This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

    Dosage

    • Missed Dose

      Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of a missed dose is very low.

    • Overdose

      Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.

    Interactions

    Interaction with Medicines
    • Amitriptyline severe
    • Monoamine oxidase inhibitors moderate
    • Levothyroxine moderate
    • Beta blockers moderate
    • Clomipramine severe
    • Imipramine severe
    Disease interactions
    • severe

      This medicine is not recommended for use in patients with peripheral vascular thrombosis unless absolutely necessary in life- saving condition.

    General Instructions

    This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.

    Other details

    • Usage does not depend on food timings
    • To be taken as instructed by doctor
    • Effect on sleep is not established

    References

    • https://pubchem.ncbi.nlm.nih.gov/compound/norepinephrine - Norepinephrine [Internet]. Available from: pubchem [cited 1/7/2021]. 2021

    Additional Information>

    How to use Norepine Injection 2 mg 10 Amp

    By IV infusion into a large vein. A 4 mcg/mL dilution of norepinephrine base for infusion is usually prepared by adding 4 mg of base (4 mL) to 1000 mL of D5W with or without NS.
    Reconstitution: Dilute with D5W or D5NS, but not recommended to dilute in NS. Stable for 24 hours at room temp.
    Compatibility: Stable in D5NS, D5W, LR. Avoid contact with iron salts, alkalis, or oxidizing agents. Administer whole blood or plasma separately (i.e. by use of a Y-tube and individual containers if given simultaneously).
    Y-site administration:
    Drug to Drug IV Compatibility: Amikacin, amiodarone, aztreonam, bumetanide, calcium gluconate, cephazolin, ceftriaxone, ciprofloxacin, cisatracurium, dexamethasone, diltiazem, diphenhydramine, dobutamine, dopamine, enalapril, epinephrine, esmolol, famotidine, fentanyl, fluconazole, gentamicin, heparin, hydrocortisone, hydromorphone, imipenem, labetalol, linezolid, lorazepam, magnesium sulphate, meropenem, methylprednisolone, metoclopramide, midazolam, milrinone, morphine, nitroglycerin, nitroprusside, ondansetron, phenylephrine, piperacillin/tazobactam, propofol, ranitidine, tobramycin, vancomycin, vasopressin, vecuronium.
    Drug to Drug IV Incompatibility: Insulin regular, thiopental.
    When admixed: Incompatible with aminophylline, amobarbital, chlorothiazide, chlorpheniramine, pentobarbital, phenobarbital, phenytoin, sodium bicarbonate, streptomycin, thiopental.
    Stability: Store at 25°C (77°F), excursions are permitted to 15°C-30°C (59°F-86°F). Protect from light.

    UNLICENSED USE
    Children: 1 mg of noradrenaline base is equivalent to 2 mg of noradrenaline acid tartrate. Dose expressed as the base. Acute hypotension (septic shock) or shock secondary to excessive vasodilation (as noradrenaline): Continuous IV infusion. Neonate, 20-100 nanograms (base)/kg/minute adjusted according to response; max 1 mcg (base)/kg/minute; 1 mth-18 yr, 20-100 nanograms (base)/kg/minute adjusted according to response; max. 1 mcg (base)/kg/minute.

    what are the adverse effects of Norepine Injection 2 mg 10 Amp?

    Hypertension, headache, bradycardia, arrhythmias, peripheral ischaemia.

    What happens if I miss a dose of Norepine Injection 2 mg 10 Amp?

    Acute hypotension: Adults: By intravenous infusion, via central venous catheter, of a solution containing noradrenaline acid tartrate 80 mcg/ mL (equivalent to noradrenaline base 40 mcg/ mL) at an initial rate of 0.16-0.33 mL/min, adjusted according to response.
    Cardiac arrest: Adults: By rapid intravenous or intracardiac injection, 0.5-0.75 mL of a solution containing noradrenaline acid tartrate 200 mcg/ mL (equivalent to noradrenaline base 100 mcg/ mL).

    One of the following licensed pharmacy from the nearest location will deliver Norepine Injection 2 mg 10 Amp. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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