Nucala 100 mg powder for solution for injection

Nucala (mepolizumab) is a prescription medication used to treat severe eosinophilic asthma and other eosinophilic conditions. Each vial contains 100 mg of mepolizumab as a powder that must be reconstituted and administered as an injection by a healthcare professional.

How It Works

Mepolizumab is a monoclonal antibody that targets and inhibits interleukin-5 (IL-5), a cytokine that plays a key role in the growth, activation, and survival of eosinophils. By blocking IL-5, mepolizumab reduces the number of eosinophils in the blood, which helps control inflammation and symptoms in patients with eosinophilic conditions.

Side Effects

• Headache
• Injection site reactions (pain, redness, swelling)
• Back pain
• Fatigue
• Upper respiratory tract infections
• Nausea
• Hypersensitivity reactions (rash, itching, swelling)

Indications

• Severe eosinophilic asthma in adults and adolescents aged 12 years and older
• Eosinophilic granulomatosis with polyangiitis (EGPA)
• Hypereosinophilic syndrome (HES)

Contraindications

• Known hypersensitivity to mepolizumab or any of its components
• Acute bronchospasm or status asthmaticus

Price in Different Countries

Top 5 Global Brands

• GlaxoSmithKline (GSK) – Manufacturer of Nucala
• Novartis
• Roche
• Sanofi
• Pfizer