Odefsey 200 mg/25 mg/25 mg Film-coated Tablets

How it Works:

Odefsey works by inhibiting the replication of the human immunodeficiency virus (HIV) in the body. Emtricitabine
and tenofovir alafenamide are nucleoside reverse transcriptase inhibitors (NRTIs), which block an enzyme called
reverse transcriptase that HIV needs to replicate. Rilpivirine is a non-nucleoside reverse transcriptase
inhibitor (NNRTI) that works similarly to inhibit HIV replication.

Side Effects:

• Nausea
• Diarrhea
• Headache
• Fatigue
• Insomnia

Indications:

• Treatment of HIV-1 infection in adults and pediatric patients weighing at least 35 kg
• Maintenance treatment of HIV-1 infection in virologically suppressed adults

Contraindications:

• Hypersensitivity to any components of Odefsey
• Coadministration with drugs that are strong inducers of CYP3A (may reduce the efficacy of rilpivirine)
• Coadministration with drugs that increase gastric pH (may reduce the absorption of tenofovir alafenamide)
• Severe renal impairment (creatinine clearance <30 mL/min)
• Breastfeeding (due to the potential for HIV transmission and adverse reactions)

Price Comparison:

Top 5 Global Brands:

1. Gilead Sciences (Manufacturer of Odefsey)
2. ViiV Healthcare
3. Bristol Myers Squibb
4. Merck & Co.
5. AbbVie