Ondavell Injection 4 mg 5 Ampx2 mL

 725.00

Manufactured by:
Active Pharmaceutical Ingredient:
Drug Strength: 4 mg
Drug Form : Injection
Pack Size : 5 Ampx2 mL
Does this requires a prescription ?Yes

Ondavell Injection contains Ondansetron | belongs to 5HT3-antagonist

SKU: pg_17017_23571 Categories: ,

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    How it works

    Ondavell Injection 4 mg 5 Ampx2 mL blocks the action of chemicals (serotonin) in the body that can trigger nausea and vomiting.

    Side effects

    Major & minor side effects for Ondavell Injection 4 mg 5 Ampx2 mL

    • Headache severe
    • Constipation severe
    • Fatigue severe
    • Painful urination severe
    • Fever
    • Dry mouth
    • Anxiety

    Uses of Ondavell Injection 4 mg 5 Ampx2 mL

    What is it prescribed for?

    • Nausea and vomiting

      Ondavell Injection 4 mg 5 Ampx2 mL is used to treat nausea and vomiting.

    • Chemotherapy induced nausea and vomiting

      Ondavell Injection 4 mg 5 Ampx2 mL is used to treat nausea and vomiting in cancer chemotherapy patients.

    • Post operative nausea and vomiting

      Ondavell Injection 4 mg 5 Ampx2 mL is used to treat nausea and vomiting in post-operative patients

    Concerns

    Frequently asked questions

    • Onset of action

      The peak effect of Ondavell Injection 4 mg 5 Ampx2 mL can be observed within 30 minutes for Intravenous and 2 hours for the tablet.

    • Duration of Effect

      This medicine is excreted primarily in urine and the effect of this medicine lasts for a duration of 12 to 28 hours.

    • Safe with Alchohol?

      Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

    • Is it habit forming?

      No habit forming tendency has been reported.

    • Usage in pregnancy?

      Use of Ondavell Injection 4 mg 5 Ampx2 mL is not recommended in pregnant women.

    • Usage while breast-feeding?

      No clear data is available whether Ondavell Injection 4 mg 5 Ampx2 mL is excreted through human breast milk. So, use of this drug is not recommended in breastfeeding women.

    When not to use?

    • Allergy

      Avoid if the patient has a known allergy to Ondavell Injection 4 mg 5 Ampx2 mL .

    • Apomorphine

      Avoid using Ondavell Injection 4 mg 5 Ampx2 mL with Ondavell Injection 4 mg 5 Ampx2 mL as it increases the risk of lightheadedness and loss of consciousness.

    Warnings

    Warnings for special population
    • Pregnancy

      Use of Ondavell Injection 4 mg 5 Ampx2 mL is not recommended in pregnant women.

    • Breast-feeding

      No clear data is available whether Ondavell Injection 4 mg 5 Ampx2 mL is excreted through human breast milk. So, use of this drug is not recommended in breastfeeding women.

    General Warnings
    • Hypersentivity

      Avoid if the patient has a known allergy to Ondavell Injection 4 mg 5 Ampx2 mL .

    • Liver disease

      Avoid using if the patient is having any liver disease as there are reports of Ondavell Injection 4 mg 5 Ampx2 mL increasing patient's liver enzymes.

    • Paediatics

      Avoid using in children who are younger than 4 years.

    Dosage

    • Missed Dose

    • Overdose

      Seek emergency medical attention or contact the doctor in case of overdose.

    Interactions

    Interaction with Medicines
    • Amitriptyline severe
    • Carbamazepine moderate
    • Phenytoin moderate
    • Amiodarone severe
    • Apomorphine severe
    • Cyclophosphamide moderate
    Disease interactions
    • severe

      Details of any heart disease, family history of an arrhythmia or any other drugs that cause QT interval prolongation (eg: Antipsychotics, Arrhythmia drugs) should be reported to the doctor. Regular cardiac function tests are to be performed if the patient is having any heart disease.

    • moderate

      Details of any liver disease (jaundice, hepatitis) or other drugs that may affect the liver (eg: TB drugs, HIV drugs) should be reported to the doctor. Regular liver function tests are to be performed if the patient is having any liver disease.

    General Instructions

    Take Ondavell Injection 4 mg 5 Ampx2 mL with or without food. Do not take in larger amounts than advised. Consult the doctor if the patient experiences any undesirable effects.

    Other details

    • Food timings: Information not available
    • Administration time: Information not available
    • Sleep inducing: Information not available

    References

    Additional Information>

    How to use Ondavell Injection 4 mg 5 Ampx2 mL

    IM: Should be given undiluted. IV: Give first dose 30 min prior to beginning chemotherapy; the IV preparation has been successful when administered orally. IVPB: Infuse over 15-30 min; 24-hour continuous infusions have been reported, but are rarely used.
    Reconstitution: Prior to IV infusion, dilute in 50-100 mL D5W or NS.
    Compatibility: Stable in D5 ½ NS, D5NS, D5W, mannitol 10%, LR, NS, NS 3%. Do not mix injection with alkaline solutions.
    Y-site administration:
    Drug to Drug IV Compatibility: Amikacin, azithromycin, aztreonam, bumetanide, calcium gluconate, cephazolin, cimetidine, ciprofloxacin, cisatracurium, dexamethasone, diltiazem, diphenhydramine, dobutamine, dopamine, enalapril, epinephrine, esmolol, famotidine, fentanyl, fluconazole, gentamicin, heparin, hydrocortisone, hydromorphone, imipenem, labetalol, levofloxacin, linezolid, magnesium sulphate, metoclopramide, midazolam, morphine, nitroglycerin, nitroprusside, norepinephrine, phenylephrine, piperacillin/tazobactam, propofol, ranitidine, tobramycin, vancomycin, vasopressin.
    Drug to Drug IV Incompatibility: Acyclovir, allopurinol, aminophylline, amphotericin B, ampicillin, ampicillin/sulbactam, cefepime, cefoperazone, furosemide, ganciclovir, lansoprazole, lorazepam, meropenem, methylprednisolone, pantoprazole, sodium succinate, piperacillin, sodium bicarbonate.
    Stability: Store vials between 2°C-30°C. Protect from light. Stable when mixed in 5% dextrose or 0.9% NaCl for 48 hours at room temperature.

    what are the adverse effects of Ondavell Injection 4 mg 5 Ampx2 mL?

    Constipation, headache, flushing. Transient rise in liver enzymes. Rarely hypersensitivity reactions, anaphylaxis, chest pain, ST segment depression, cardiac arrhythmia, hypotension, bradycardia, extrapyramidal reactions, seizures, visual disturbance.

    What happens if I miss a dose of Ondavell Injection 4 mg 5 Ampx2 mL?

    Adults: Chemotherapy and radiotherapy: Highly emetogenic regimens: Single dose of 8 mg by slow IV inj immediately prior to chemotherapy; or 8 mg by slow IV inj prior to chemotherapy followed by either two doses of 8 mg by IV inj repeated 2-4 hr apart or by 1 mg per hr by IV infusion for up to 24 hr; or single dose of 32 mg in 50-100 mL saline infused over 15 min prior to chemotherapy. After first 24 hrs, follow by 8 mg orally twice daily for up to 5 days. Efficacy may be enhanced by addition of dexamethasone 20 mg IV prior to chemotherapy.
    Less emetogenic regimens: 8 mg by slow IV inj immediately prior to chemotherapy, or orally 1-2 hr before, followed by 8 mg orally twelve hrly. After first 24 hrs, follow by 8 mg orally twice daily for up to 5 days.
    Postoperative prophylaxis: 8 mg orally 1 hr prior to anaesthesia followed by two doses of 8 mg orally at 8 hrly intervals; or single dose of 4 mg by slow IV or IM inj at induction of anaesthesia. Treatment, single dose of 4 mg by slow IV or IM inj.
    Children: Prevention and treatment of chemotherapy- and radiotherapy-induced nausea and vomiting (Not licensed for radiotherapy-induced nausea and vomiting): By IV infusion over at least 15 minutes. 6 mth-18 yr, either 5 mg/square meter immediately before chemotherapy (8 mg if body surface area greater than 1.2 square meter), then given by mouth, or 150 mcg/kg immediately before chemotherapy (max single dose 8 mg) repeated every 4 hr for 2 further doses, then given by mouth; max total daily dose 32 mg. By mouth following IV administration. Oral dosing can start 12 hr after IV administration: 6 mth-18 yr, Body surface area less than 0.6 square meter or bodyweight 10 kg or less, 2 mg every 12 hr for up to 5 days (max total daily dose 32 mg); Body surface area 0.6-1.2 square meter or body-weight over 10 kg, 4 mg every 12 hr for up to 5 days (max total daily dose 32 mg); Body surface area greater than 1.2 square meter or body weight over 40 kg, 8 mg every 12 hr for up to 5 days (max total daily dose 32 mg).
    Treatment and prevention of postoperative nausea and vomiting: By slow IV injection over at least 30 sec. 1 mth-18 yr, 100 mcg/kg (max 4 mg) as a single dose before, during, or after induction of anaesthesia.

    One of the following licensed pharmacy from the nearest location will deliver Ondavell Injection 4 mg 5 Ampx2 mL. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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