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Orencia Abatacept 125mg Injection

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How it Works

Orencia (abatacept) is a biologic medication used to treat autoimmune conditions such as rheumatoid arthritis, juvenile idiopathic arthritis, and psoriatic arthritis. It works by modulating the immune system. Abatacept is a fusion protein composed of the extracellular domain of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) linked to a modified Fc portion of human immunoglobulin G1 (IgG1). By binding to CD80 and CD86 on antigen-presenting cells, abatacept inhibits the co-stimulation of T cells. This action prevents the activation of T cells, which play a critical role in the inflammatory process of autoimmune diseases, thereby reducing inflammation and tissue damage.

Side Effects

  • Headache
  • Nausea
  • Upper respiratory tract infections
  • Nasopharyngitis (common cold)
  • Fatigue
  • Urinary tract infections
  • Cough
  • Back pain
  • Hypertension (high blood pressure)
  • Rash
  • Infusion-related reactions
  • Dizziness


  • Moderate to severe rheumatoid arthritis in adults, as a monotherapy or in combination with other disease-modifying antirheumatic drugs (DMARDs)
  • Moderate to severe juvenile idiopathic arthritis in patients 2 years of age and older
  • Active psoriatic arthritis in adults


  • Hypersensitivity to abatacept or any of its excipients
  • Severe infections, such as sepsis or opportunistic infections
  • Concurrent use with TNF antagonists (due to increased risk of infections)
  • Immunocompromised patients

Price Comparison in Different Countries

Country Price (USD) Website
United States $4,000 per dose GoodRx
Canada $3,500 per dose PharmacyChecker
United Kingdom £3,000 per dose NHS
Australia AUD 5,200 per dose PBS
India ₹280,000 per dose Medindia

Top 5 Global Brands

  1. Orencia (Bristol-Myers Squibb)
  2. Humira (AbbVie)
  3. Enbrel (Amgen)
  4. Remicade (Janssen Biotech, Inc.)
  5. Simponi (Janssen Biotech, Inc.)


Additional Information:

One of the following licensed pharmacy from the nearest location will deliver Orencia Abatacept 125mg Injection. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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