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Information on this page was last modified on : 2019/08/10 6:07:44 PM

Orex tablet 20 mg 10x10's

, This drug requires a valid prescription from PMDC registered health practitioner.
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Contains

Orex tablet contains Furosemide | belongs to Loop diuretic

Product SKUpg_17248_23838
Belongs to Category
Drug Strength
Pack size

Side effects

Major & minor side effects for Orex tablet 20 mg 10×10’s

  • Low potassium and magnesium severe
  • Decreased calcium level severe
  • Hearing impairment severe
  • Headache severe
  • Weakness
  • Increased sensitivity of the skin to sunlight
  • Muscle spasm
  • Skin rash

Uses of Orex tablet 20 mg 10×10’s

What is it prescribed for?

  • Hypertension

    Orex tablet 20 mg 10×10’s is used in the treatment of hypertension which is a condition with an increase in the blood pressure caused by fluid overload due to genetic and environmental factors.

  • Congestive Heart Failure

    Orex tablet 20 mg 10×10’s is used in the treatment of congestive heart failure characterized by the decrease in the blood flow to the body parts.

  • Edema

    Orex tablet 20 mg 10×10’s is used to remove water that accumulated in the hands, feet, and ankles associated due to cirrhosis of the liver, and renal disease

Concerns

Frequently asked questions

  • Onset of action

    Orex tablet 20 mg 10×10’s is used to remove water that accumulated in the hands, feet, and ankles associated due to cirrhosis of the liver, and renal disease The effect of this medicine can be observed in 30 to 60 minutes after an oral dose, 30 minutes after an intramuscular dose and 5 min after an intravenous dose.

  • Duration of Effect

    The effect of this medicine lasts for an average duration of 6 to 8 hours after an oral dose and 2 hours after an intravenous dose.

  • Safe with Alchohol?

    Consumption of alcohol is not recommended while you are taking this medicine due to the increased risk of severe adverse effects. These side effects may include dizziness and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery if you consume alcohol during treatment with this medicine.

  • Is it habit forming?

    No habit forming tendency has been reported.

  • Usage in pregnancy?

    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

  • Usage while breast-feeding?

    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

When not to use?

  • Allergy

    Not recommended in patients with known allergy to Orex tablet 20 mg 10×10’s or other diuretics.

  • Anuria

    This medicine is not recommended in patients with condition Anuria (a condition wherein the kidney is unable to produce urine).

Warnings

Warnings for special population
  • Pregnancy

    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

  • Breast-feeding

    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Warnings

Warnings for special population
  • Severe liver injury with Cirrhosis and Ascites

    Orex tablet 20 mg 10×10’s should be used with caution in the patients suffering from liver diseases such as severe liver injuries, cirrhosis, ascites, etc. since it may worsen the patient's condition. Close monitoring of electrolytes levels and liver function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

  • Volume depletion and Electrolyte imbalance

    Orex tablet 20 mg 10×10’s may alter the blood volume levels and electrolyte levels. This may cause dizziness, dry mouth, and acid-base imbalance. Close monitoring of blood pressure and electrolyte levels is necessary. Therapy with the medicine should be discontinued if these symptoms appear. Therapy may be started again once the lab tests are back to normal. Replacement with a suitable alternative may be considered under your doctor's supervision.

  • Hearing problem

    Orex tablet 20 mg 10×10’s may increase the risk of developing a hearing problem when rapid intravenous injections are given. This risk is especially higher in patients receiving other medicines which may cause an adverse effect on the hearing. Any symptoms such as hearing difficulties, ringing in the ears, etc. should be reported to the doctor immediately. Replacement with a suitable alternative may be required in some cases based on the clinical condition.

  • Dizziness

    This medicine may cause dizziness in some patients. It is advised that you do not perform activities such as driving a vehicle or operating machinery if you experience any dizziness during treatment with this medicine. Also, report any symptoms such as dizziness or lightheadedness to the doctor immediately.

Dosage

  • Missed Dose

    Oral forms: The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not double your dose to make up for the missed one. Injection: Since this medicine is administered by a qualified healthcare professional, the likelihood of missing a dose is very low.

  • Overdose

    Oral forms: Seek emergency medical treatment or contact the doctor in case of an overdose. Injection: Since this medicine is administered by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated if an overdose is suspected.

Interactions

Interaction with Medicines
  • Nonsteroidal anti-inflammatory drugs moderate
  • Aminoglycoside antibiotics severe
  • Antidepressants moderate
Disease interactions
  • moderate

    This medicine should be used with caution in patients with diabetes due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is necessary during therapy with this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

General Instructions

Take Orex tablet 20 mg 10×10’s as advised by your doctor. Do not take in larger or smaller amounts than prescribed. Take this medicine at daytime to prevent sleep disturbance. Drink an adequate amount of water. This medicine should be used with caution due to the risk of dizziness. Report any symptoms such as dizziness, lightheadedness, etc. to the doctor immediately. Do not stop the use of this medicine without consulting your doctor.

Other details

  • Can be taken with or without food, as advised by your doctor
  • To be taken in morning only
  • Does not cause sleepiness

How it works

It works by increasing the excretion of water and sodium by preventing its reabsorption in the kidneys.

References

How to use Orex tablet 20 mg 10×10’s

IV: IV injections should be given slowly over 1-2 min; maximum rate of administration for IVPB or infusion: 4 mg/min; replace parenteral therapy with oral therapy as soon as possible.
Edema: Initial dose: 20-40 mg IM or IV. Give the IV injection slowly (1 to 2 min); ordinary, prompt diuretics ensure. If needed, another dose may be given in the same manner 2 hours later. The dose may be raised by 20 mg and given no sooner than 2 hours after previous dose, until desired diuretic effect is obtained. This dose should then be given once or twice daily. Administer high dose parenteral therapy as a controlled infusion at a rate = 4 mg/min.
Acute pulmonary edema: The usual initial dose is 40 mg IV (over 1 to 2 min). If response is not satisfactory within 1 hour, increase to 80 mg IV (over 1 to 2 min). Additional therapy (e.g. digitalis, oxygen) may be given concomitantly.
CHF and chronic renal failure: It has been suggested that doses as high as 2 to 2.5 gm/day or more are well tolerated and effective in these patients. For IV bolus injection, the maximum dose should not exceed 1 gm/day given over 30 min.
Reconstitution: IV Infusion solution mixed in NS or D5W solution is stable for 24 hours at room temperature.
Compatibility: Stable in D5LR, D5NS, D5W, D10W, D20W, mannitol 20%, LR, NS.
Y-site administration:
Drug to Drug IV Compatibility: Acyclovir, amikacin, aztreonam, bumetanide, calcium gluconate, cephazolin, cefepime, ceftriaxone, cimetidine, dexamethasone, enalapril, epinephrine, fentanyl, heparin, hydrocortisone, hydromorphone, imipenem, insulin regular, linezolid, lorazepam, meropenem, methylprednisolone, nitroglycerin, nitroprusside, piperacillin/tazobactam, propofol, ranitidine, tobramycin.
Stability: Exposure to light may cause slight discoloration. Do not dispense discolored tablet or use discolored injection. Store injection at room temperature (15°C- 30°C).

what are the adverse effects of Orex tablet 20 mg 10×10’s

Disorders of electrolyte balance, dehydration, allergic reactions, GI upset, hypotension, rash, hyperuricaemia, hyperglycaemia, raised serum creatinine.

What is the dose of Orex tablet 20 mg 10×10’s

ORAL: Adults: Treatment is usually begun with 20-80 mg as single dose daily or on alternate days. Children: 1-3 mg/kg daily.
Heart Failure: Adults: Usual: 20-80 mg as single dose, may repeat or increase by 20-40 mg after 6-8 hr. Max: 600 mg/day. Children: Usual: 2 mg/kg as single dose, may increase by 1-2 mg/kg after 6-8 hr. Max: 6 mg/kg.
Hypertension: Adults: Initial: 40 mg twice daily. Maintenance: Adjust according to response.
INJECTION: Adults: Initially 20-40 mg as single dose IM or slow IV. Children: 0.5-1.5 mg/kg daily.
Heart Failure: Adults: IV/IM: 20-40 mg. May repeat or increase by 20 mg after 2 hr. Children: 1 mg/kg single dose. May increase by 1 mg/kg after 2 hr. Max: 6 mg/kg.

One of the following licensed pharmacy from the nearest location will deliver Orex tablet 20 mg 10×10’s. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts the your request based on valid prescription and availability.

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