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Information on this page was last modified on : 2020/06/29 1:57:08 PM

Pentafen Injection 5 Ampx1 mL

Pentafen Injection contains Pentazocine | belongs to Opioid analgesic

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How it works

Causes sleepiness Pentafen Injection 5 Ampx1 mL blocks the pain signals from reaching the brain.

Side effects

Major & minor side effects for Pentafen Injection 5 Ampx1 mL

  • Hypersensitivity severe
  • Drowsiness severe
  • Change in mood severe
  • Headache severe
  • Constipation severe
  • Nausea and vomiting
  • Allergic skin reaction severe
  • Respiratory depression severe
  • Trouble sleeping severe
  • Blurred vision severe

Uses of Pentafen Injection 5 Ampx1 mL

What is it prescribed for?

  • Anesthesia

    This medicine is used as preoperative or pre-anesthetic medication as well as a supplementation to surgical anesthesia to maintain the level of anesthetic effect.

  • Moderate to severe pain

    Pentafen Injection 5 Ampx1 mL is used to relieve moderate to severe pain when the patient's pain is not adequately controlled by alternative analgesic medicines or the pain is severe enough to require the use of an opioid analgesic.

  • Labor pain

    Pentafen Injection 5 Ampx1 mL is used to relieve the severe pain experienced by women during delivery of a baby.

Concerns

Frequently asked questions

  • Onset of action

    The effect of this medicine can be observed within 15 to 30 minutes of an oral, subcutaneous, or intramuscular dose and within 2 to 3 minutes of an intravenous dose.

  • Duration of Effect

    The effect of this medicine lasts for an average duration of 3 hours.

  • Safe with Alchohol?

    Alcohol should not be consumed while receiving this medicine since it may increase the risk of drowsiness, lightheadedness, impairment in thinking and judgment, etc. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating heavy machinery if you consume alcohol during treatment with this medicine.

  • Is it habit forming?

    Habit forming tendency has been reported, especially after prolonged use. Patients should be monitored closely for any signs of abuse or addiction. Proper assessment of the patient, periodic reevaluation, and proper dispensing is recommended to limit the abuse of this medicine.

  • Usage in pregnancy?

    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

  • Usage while breast-feeding?

    This medicine is not recommended for use in breastfeeding women. Your doctor will prescribe a safer alternative based on your clinical condition.

When not to use?

  • Hypersensitivity

    This medicine is not recommended for use in patients with a known allergy to Pentafen Injection 5 Ampx1 mL or any other components present along with it.

Warnings

Warnings for special population
  • Pregnancy

    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

  • Breast-feeding

    This medicine is not recommended for use in breastfeeding women. Your doctor will prescribe a safer alternative based on your clinical condition.

Warnings

Warnings for special population
  • Use in pediatrics

    This medicine is not recommended for use in children less than 1 year of age.

  • Respiratory depression

    This medicine may cause life-threatening respiratory depression. Close monitoring of respiratory function is recommended while using this medicine. Equipment for resuscitation should be immediately available if the injection form of this medicine is used.

  • Neonatal Opioid Withdrawal Syndrome

    This medicine may cause life-threatening withdrawal symptoms in neonates born to women who were under prolonged therapy with Pentafen Injection 5 Ampx1 mL . Such neonates should be monitored closely for any unusual side effects. Appropriate corrective measures may be required based on the clinical condition.

  • Adrenal insufficiency

    This medicine may cause adrenal insufficiency like other opioid medicines, hence caution is advised while using this medicine for more than one month. Any unusual symptoms should be reported to the doctor on priority. Appropriate corrective measures, gradual withdrawal of therapy, and replacement with a suitable alternative may be required based on the clinical condition.

  • Severe hypotension

    Pentafen Injection 5 Ampx1 mL may cause severe hypotension while getting up from a lying or a sitting position. Patients are advised to get up slowly from a sitting or a lying position to avoid sudden hypotension, fainting, dizziness, etc. Report any unusual symptoms to the doctor immediately. Close monitoring of blood pressure, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

  • Withdrawal symptoms

    Abrupt discontinuation of Pentafen Injection 5 Ampx1 mL therapy may cause withdrawal symptoms, especially after a prolonged use. Gradual tapering of dosage is recommended to avoid withdrawal symptoms.

  • Sports

    Use of this medicine is prohibited at all times according to category S7 of World Anti-Dopping Agency (WADA).

  • Drowsiness

    This medicine causes drowsiness. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery during treatment with this medicine.

Dosage

  • Missed Dose

    Injection: Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of missing a dose is very low. Tablets: This medicine is usually taken as required. If you are on a scheduled dosing of this medicine, take the missed dose as soon as you remember. It is advisable to skip the missed dose if it is almost time for the next scheduled dose.

  • Overdose

    Injection: Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected. Tablets: Seek emergency medical treatment or contact the doctor immediately if an overdose with this medicine is suspected.

Interactions

Interaction with Medicines
  • Baclofen severe
  • Citalopram severe
  • Ondansetron severe
  • Tramadol severe
  • Alprazolam severe
  • Fentanyl severe
  • Alvimopan severe
Disease interactions
  • severe

    Therapy with Pentafen Injection 5 Ampx1 mL should be administered cautiously in patients with impaired gastrointestinal function due to the increased risk of constipation, elevated intraluminal pressure, and spasm. Patients should be monitored closely for any adverse effects. Replacement with a suitable alternative may be required based on the clinical condition.

  • severe

    Therapy with opioids should be avoided or administered cautiously in patients with infectious diarrhea, particularly that due to pseudomembranous enterocolitis or enterotoxin-producing bacteria or if accompanied by high fever, pus, or blood in the stool. Pentafen Injection 5 Ampx1 mL may prolong and/or worsen diarrhea.

  • severe

    Therapy with opioids should be administered cautiously and initiated at reduced dosages in patients with liver diseases due to the increased risk of severe adverse effects. Subsequent doses should be titrated based on individual response rather than a fixed dosing schedule.

  • severe

    Therapy with opioids should be administered cautiously and initiated at reduced dosages in patients with renal dysfunction due to the increased risk of severe adverse effects. Subsequent doses should be titrated based on individual response rather than a fixed dosing schedule.

  • severe

    Opioid analgesics should be administered cautiously and only if the benefit of using this medicine outweighs the risks in patients with coronary insufficiency or acute myocardial infarction.

  • severe

    Caution is advised while using this medicine in patients with a head injury, intracranial lesions, or pre-existing elevated CSF pressure due to the increased risk of cerebral hypoxia and vasodilation leading to increased intracranial pressure.

  • severe

    Therapy with opioids should be administered cautiously and initiated at reduced dosages in patients with severe CNS or respiratory depression due to the increased risk of worsening of the patient's condition. Close monitoring of pulmonary function is recommended for such patients. Equipment for resuscitation should be immediately available if required.

General Instructions

Injection: Pentafen Injection 5 Ampx1 mL is usually administered by a qualified healthcare professional. Carefully follow all the instructions given by your doctor. Consult the doctor if you experience any undesirable side effects. Tablets: Take Pentafen Injection 5 Ampx1 mL as instructed by your doctor. Do not take in larger quantities than advised/prescribed. Do not share this medicine with others. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.

Other details

  • Usage does not depend on food timings
  • To be taken as instructed by doctor
  • Causes sleepiness

References

How to use Pentafen Injection 5 Ampx1 mL

IM: Rotate injection site; avoid intra-arterial injection. Other: Rotate injection site for SC use; avoid SC use unless absolutely necessary (may cause tissue damage); avoid intra-arterial injection.
Stability: Store at 20°C-25°C. Do not freeze. Protect from light.

what are the adverse effects of Pentafen Injection 5 Ampx1 mL

Sedation, dizziness, nausea. Psychotomimetic effects.

What is the dose of Pentafen Injection 5 Ampx1 mL

ORAL: Adults: 25-100 mg three to four hourly after meals. Children: 6-12 yr, 25 mg 3-4 hourly. Under 6 yr, Not recommended.
INJECTION: Adults: 30-60 mg IM or SC or IV three or four hourly. Children: Under 1 yr, not recommended; 1-12 yr, max single dose 1 mg/kg body weight IM or SC or 0.5 mg/kg body weight IV.

One of the following licensed pharmacy from the nearest location will deliver Pentafen Injection 5 Ampx1 mL. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts the your request based on valid prescription and availability.

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