₨ 75,000.00
MBBS
Rapilysin Injection 10 IU 2 Vialx10 mL
- Does this requires a prescription ? Yes
- Generic Name: Reteplase
- Manufactured by : Excel Healthcare Laboratories (PVT.) LTD.
- Drug Strength : 10 IU
- Drug Form : Injection
- Pack Size : 2 Vialx10 mL
- Product SKU : pg_19551_26961
Rapilysin Injection contains Reteplase | belongs to Fibrinolytic
How it works
Rapilysin Injection 10 IU 2 Vialx10 mL helps your body produce a substance that dissolves unwanted blood clots.
Side effects
Major & minor side effects for Rapilysin Injection 10 IU 2 Vialx10 mL
- Bleeding at injection site
- Blood in urine
- Stomach pain
- Pale skin
- Unusual tiredness or weakness
- Blurred vision rare
- Dizziness rare
- Fast heartbeat rare
- Confusion rare
Uses of Rapilysin Injection 10 IU 2 Vialx10 mL
What is it prescribed for?
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Acute myocardial infarction
This medicine is used in the treatment of acute myocardial infarction to dissolve the blood clots by binding to the proteins involved in the formation of the clots and restores the blood circulation to the blocked blood vessels.
Concerns
Frequently asked questions
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Onset of action
The effect of this medicine can be observed within 30-90 minutes of administration of the dose.
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Duration of Effect
The amount of time for which this medicine remains active in the body is not clinically established.
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Safe with Alchohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
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Is it habit forming?
No habit-forming tendencies were reported.
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Usage in pregnancy?
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
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Usage while breast-feeding?
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
When not to use?
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Allergy
This medicine is not recommended for use in patients with a known allergy to Rapilysin Injection 10 IU 2 Vialx10 mL or any other inactive ingredients present in the formulation.
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Bleeding
This medicine is not recommended for use in patients who have a current intracranial hemorrhage, subarachnoid hemorrhage, active internal bleeding, or underwent any intracranial or intraspinal surgery or serious head trauma within the past 3 months.
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Severe uncontrolled hypertension
This medicine is not recommended for use in patients with severe uncontrolled hypertension due to the increased risk of worsening of the patient's condition.
Warnings
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Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
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Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
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Severe Bleeding
This medicine may increase the risk of bleeding, therefore should be used with caution in patients with any bleeding disorder. Inform the doctor if you have any gastrointestinal diseases, previous history of trauma, surgery, stroke or uncontrolled hypertension . Close monitoring is necessary and therapy should be discontinued in case of any signs of internal bleeding.
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Use in children
This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.
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Use in Elderly
This medicine should be used with extreme caution in the elderly, as the risk of adverse effects were significantly high.
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Severe Liver/Kidney Disease
This medicine should be used with caution in patients with severe liver/kidney diseases due to the increased risk of adverse effects. Regular monitoring of liver/kidney function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Dosage
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Missed Dose
Since this medicine is administered in a clinical setting under the supervision of a healthcare professional the chances of missing a dose is rare.
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Overdose
Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
Interactions
Interaction with Medicines- Dabigatran severe
- Etodolac moderate
- Citalopram moderate
- Duloxetine moderate
- Fluvoxamine moderate
- Apixaban severe
- Abciximab severe
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This medicine is not recommended for use in patients with cardiovascular diseases like portal hypertension, severe uncontrolled hypertension. Caution is advised to use in patients with arrhythmias due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
General Instructions
This medicine is usually to administered under the supervision of a doctor in a clinical setup with regular monitoring of blood clotting time and other related parameters. It should not be injected into the muscles. Your doctor may ask you to undergo certain tests to determine the safety of use of this medicine.
Other details
- Usage does not depend on food timings
- To be taken as instructed by doctor
- May cause sleepiness
References
- drugs.com - Reteplase [Internet]. Available from: https://www.drugs.com/mtm/reteplase.html [cited 8/9/2020]. 2020
How to use Rapilysin Injection 10 IU 2 Vialx10 mL
Administer IV over 2 min. No other medication should be added to injection solution. Give each bolus injection via an IV line in which no other medication is being simultaneously injected or infused. Flush the heparin line with NS or D5W before and after reteplase injection.
Reconstitution: To reconstitute use diluent, syringe, needle and dispensing pin provided. Withdraw 10 mL of preservative-free SWFI. Remove and discard needle from syringe and connect dispensing pin to syringe. Remove protective cap from spike end of dispensing pin and insert spike into reteplase vial. Inject 10 mL of sterile water into the vial. With the spike still in the vial, swirl gently to dissolve the powder. Do not shake. Expect to see slight foaming. Let the vial stand for several mins. When the bubbles dissipate, withdraw 10 mL of reconstituted solution into the syringe (about 0.7 mL may remain in the vial). Now detach the syringe from the dispensing pin and attach the 20G needle.
Compatibility: Incompatible with heparin in same IV line.
Stability: Store at 2°C-25°C (36°F-77°F). The box should remain sealed until use to protect the lyophilisate from exposure to light.
what are the adverse effects of Rapilysin Injection 10 IU 2 Vialx10 mL?
Haemorrhage, intracranial bleeding, ischaemia, hypotension, heart failure, arrhythmias, cardiac arrest, cardiogenic shock, reinfarction, injection site reactions. Rarely, hypersensitivity.
What happens if I miss a dose of Rapilysin Injection 10 IU 2 Vialx10 mL?
Adults: By IV injection, initiated within 12 hr of symptom onset, 10 units over not more than 2 min, followed after 30 min by a further 10 units. Children: Not recommended.
One of the following licensed pharmacy from the nearest location will deliver Rapilysin Injection 10 IU 2 Vialx10 mL. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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