
MBBS
Reblozyl (luspatercept-aamt) 25mg Injection
- Generic Name: luspatercept-aamt
- Drug Strength : 25mg
- Pack Size : 1
How It Works
Reblozyl (luspatercept-aamt) is an erythroid maturation agent (EMA) that works by binding to select transforming growth factor-beta (TGF-β) superfamily ligands. This binding reduces Smad2/3 signaling, which enhances late-stage erythropoiesis (the process of red blood cell formation). By promoting the maturation of erythroid precursors, Reblozyl increases hemoglobin levels and reduces the need for red blood cell transfusions in patients with specific types of anemia.
List of Side Effects
- Fatigue
- Headache
- Muscle and bone pain
- Arthralgia (joint pain)
- Dizziness
- Hypertension (high blood pressure)
- Upper respiratory tract infections
- Diarrhea
- Nausea
- Abdominal pain
List of Indications
- Treatment of anemia in adult patients with beta thalassemia who require regular red blood cell (RBC) transfusions
- Treatment of anemia in adult patients with very low- to intermediate-risk myelodysplastic syndromes (MDS) with ring sideroblasts who have failed an erythropoiesis stimulating agent (ESA) and require 2 or more RBC units over 8 weeks
List of Contraindications
- Hypersensitivity to luspatercept-aamt or any of the excipients in Reblozyl
- Pregnancy
- Women who are breastfeeding
Price in Different Countries
Country | Price (USD) | Reference Website |
---|---|---|
United States | $10,000 | GoodRx |
United Kingdom | £7,500 | NICE BNF |
Canada | $13,000 CAD | CanadaDrugs.com |
Australia | $14,500 AUD | PBS Australia |
India | ₹750,000 INR | 1mg |
Pakistan | ₨ 1,600,000 PKR | Dawaai.pk |
Top 5 Global Brands
- Reblozyl (Luspatercept-aamt) – Bristol Myers Squibb
- Jivi (BAY94-9027) – Bayer
- Oxbryta (Voxelotor) – Global Blood Therapeutics
- Adakveo (Crizanlizumab) – Novartis
- Hydrea (Hydroxyurea) – Bristol Myers Squibb
One of the following licensed pharmacy from the nearest location will deliver Reblozyl (luspatercept-aamt) 25mg Injection. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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