₨ 85.00
MBBS
Refobacin Injection 20 mg 5 Ampx1 mL
- Does this requires a prescription ? Yes
- Generic Name: Gentamicin, Inj
- Manufactured by : Martin Dow Marker
- Drug Strength : 20 mg
- Drug Form : Injection
- Pack Size : 5 Ampx1 mL
- Product SKU : pg_19679_27169
Refobacin Injection contains Gentamicin, Inj | belongs to Aminoglycoside
Alternate brands of Refobacin Injection 20 mg 5 Ampx1 mL
| Brand Name | Price | Savings |
|---|---|---|
| Skycin Injection 20 mg 5 Ampx2 mL | ₨ 44.00 | You can save 41 |
| Skycin Injection 80 mg 5 Ampx2 mL | ₨ 80.00 | You can save 5 |
| SG Injection 80 mg 5 Ampx2 mL | ₨ 99.35 | You will pay -14.35 more |
| SG Injection 40 mg 5 Ampx2 mL | ₨ 60.00 | You can save 25 |
| SG Injection 20 mg 5 Ampx2 mL | ₨ 41.65 | You can save 43.35 |
How it works
It works by inhibiting the protein synthesis which is essential for the bacteria to grow.
Side effects
Major & minor side effects for Refobacin Injection 20 mg 5 Ampx1 mL
- Abdominal pain severe
- Agitation severe
- Blurred vision severe
- Changes in urine frequency severe
- Hearing loss severe
- Dizziness when getting up suddenly from a sitting position severe
- Dry mouth severe
- Fast heartbeat severe
- Itching or rash severe
- Increased salivation
- Depression
Uses of Refobacin Injection 20 mg 5 Ampx1 mL
What is it prescribed for?
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Bacteremia
Refobacin Injection 20 mg 5 Ampx1 mL is used in the treatment of bacteremia which is an infection of the blood caused by Staphylococci and Streptococcus pyogenes.
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Intraabdominal Infection
Refobacin Injection 20 mg 5 Ampx1 mL is used in the treatment of intra-abdominal infections caused by Helicobacter pylori, Staphylococci and Streptococci.
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Bacterial Meningitis
Refobacin Injection 20 mg 5 Ampx1 mLi s used in the treatment of meningitis, which is an inflammation of the protective membranes that surround the brain and spinal cord, caused by Streptococcus pneumoniae and Neisseria meningitidis.
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Osteomyelitis
Refobacin Injection 20 mg 5 Ampx1 mL is used in the treatment of bone and joint infections like Osteomyelitis caused by Staphylococci and Streptococci species.
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Skin and Soft tissue infections
Refobacin Injection 20 mg 5 Ampx1 mL is used to treat skin and soft tissue infections caused by Staphylococcus aureus and Streptococcus pyogenes.
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Pyelonephriits
Refobacin Injection 20 mg 5 Ampx1 mL is used in the treatment of Pyelonephritis which is a type of kidney infection caused by E.coli, Pseudomonas aeruginosa, Enterococci and Klebsiella pneumoniae.
Concerns
Frequently asked questions
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Onset of action
The peak effect of this medicine can be observed in 30 to 90 minutes for an intramuscular injection and 30 minutes after an intravenous injection.
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Duration of Effect
The effect of this medicine lasts for an average duration of 6 to 8 hours.
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Safe with Alchohol?
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
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Is it habit forming?
No habit forming tendencies were reported.
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Usage in pregnancy?
This medicine is not recommended for pregnant women.
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Usage while breast-feeding?
Small amounts of this medicine is excreted in the human breast milk. Discuss with the doctor about benefits and risks. Monitoring of undesired effects like diarrhea, candidiasis is necessary.
When not to use?
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Allergy
Avoid if you have a known allergy to Refobacin Injection 20 mg 5 Ampx1 mL or any other aminoglycosides.
Warnings
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Pregnancy
This medicine is not recommended for pregnant women.
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Breast-feeding
Small amounts of this medicine is excreted in the human breast milk. Discuss with the doctor about benefits and risks. Monitoring of undesired effects like diarrhea, candidiasis is necessary.
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Hearing loss
Refobacin Injection 20 mg 5 Ampx1 mL is not recommended in the patients with existing kidney injury or hearing problem it may increase the risk of deafness.
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Impaired kidney function
Refobacin Injection 20 mg 5 Ampx1 mL may increase the risk of kidney injury especially when high doses are used or when the treatment prolongs for a longer time. Suitable dose adjustments are to be made based on the CrCl.
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Neuromuscular disorders
Refobacin Injection 20 mg 5 Ampx1 mL is not recommended in the patients with existing neuromuscular diseases like Parkinson's disease.
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Drug-resistance
Usage of Refobacin Injection 20 mg 5 Ampx1 mL without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that is drug resistant.
Dosage
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Missed Dose
The missed dose can be taken as soon as you remember. However, the missed dose should be skipped if it is almost time for your next dose.
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Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
Interactions
Interaction with Medicines- Furosemide severe
- Nonsteroidal anti-inflammatory drugs moderate
- Cephalosporins moderate
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severe
Consume an adequate amount of water to prevent kidney injury and hearing problem. Fluid status should be monitored closely in the patients with severe diarrhea and vomiting. Frequent monitoring of kidney function tests is necessary. Dose adjustments are to be made based on the clinical condition.
General Instructions
You should carefully follow all instructions on the label. The duration and amount of medicine consumed should be as prescribed by the doctor. It can be taken with food or after food. An adequate amount of water should be consumed to minimize the irritation caused in the stomach.
Other details
- Can be taken with or without food, as advised by your doctor
- To be taken as instructed by doctor
- May cause sleepiness
References
- practo.com - Gentamicin [Internet]. Available from: https://www.practo.com/medicine-info/gentamicin-128-api [cited 20 september 2019]. 16 Nov 2017
- dailymed.nlm.nih.gov - Gentamicin [Internet]. Available from: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=84f5c763-1cd3-4d85-9afb-934db8666fbf#dd8e2f25-906a-42b0-b8ce-684796a010fb [cited 20 september 2019]. September 26, 2013
- medlineplus.gov - Gentamicin [Internet]. Available from: https://medlineplus.gov/druginfo/meds/a682275.html [cited 20 september 2019]. 11 September 2019
How to use Refobacin Injection 20 mg 5 Ampx1 mL
IM: Administer by deep IM route if possible. Slower absorption and lower peak concentrations, probably due to poor circulation in the atrophic muscle, may occur following IM injection; in paralysed patients, suggest IV route. IV: Administer other antibiotics at least 1 hour before or 1 hour after gentamicin.
Compatibility: Stable in dextran 40, D5W, D10W, mannitol 20%, LR, NS. Incompatible with fat emulsion 10%.
Y-site administration:
Drug to Drug IV Compatibility: Acyclovir, amikacin, amiodarone, aztreonam, bumetanide, calcium gluconate, ciprofloxacin, cisatracurium, diltiazem, diphenhydramine, dobutamine, dopamine, enalapril, epinephrine, esmolol, famotidine, fentanyl, fluconazole, hydromorphone, imipenem, labetalol, lansoprazole, levofloxacin, linezolid, lorazepam, magnesium sulphate, meropenem, methylprednisolone, metoclopramide, midazolam, milrinone, morphine, nitroglycerin, nitroprusside, norepinephrine, ondansetron, phenylephrine, ranitidine, tobramycin, vancomycin, vasopressin, vecuronium.
Drug to Drug IV Incompatibility: Allopurinol, amphotericin B cholesteryl sulphate complex, azithromycin, cefamandole, dexamethasone, furosemide, heparin, hetastarch, hydrocortisone, idarubicin, indomethacin, iodipamide meglumine, phenytoin, propofol, warfarin.
In syringe: Incompatible with ampicillin, cefamandole, heparin.
When admixed: Incompatible with amphotericin B, ampicillin, cefamandole, cephazolin with clindamycin, cefepime, heparin, nafcillin, ticarcillin.
Stability: It should be stored between 2°C-30°C, but refrigeration is not recommended. For reconstituted solution (IV infusion mix in NS or D5W solution) are stable for 24 hours at room temperature and refrigeration.
what are the adverse effects of Refobacin Injection 20 mg 5 Ampx1 mL?
Vestibular and auditory damage, nephrotoxicity, hypomagnesaemia, blood dyscrasias, purpura, nausea, vomiting, stomatitis, signs of liver dysfunction, antibiotic associated colitis, atrophy at injection site, ototoxicity, neuromuscular blockade.
What happens if I miss a dose of Refobacin Injection 20 mg 5 Ampx1 mL?
Adults: Up to 5 mg/kg IM or IV daily in three divided doses for 7-10 days. Children: Up to 2 wk, 3 mg/kg twelve hourly; over 2 wk, 2 mg/kg eight hourly. Both IM or IV for 7-10 days.
Bone Infection: IM/IV: Adults: 3 mg/kg/day given every 8 hr. Max: 5 mg/kg/day in 3-4 doses. Reduce to 3 mg/kg/day as soon as clinically indicated. Children: 2-2.5 mg/kg every 8 hr. Infants/Neonates: 2.5 mg/kg every 8 hr. 1 wk or less: 2.5 mg/kg every 12 hr.
Lower Respiratory Infection & Meningitis & Septicaemia: IV: Adults: 3 mg/kg/day given every 8 hr. Max: 5 mg/kg/day in 3-4 doses. Reduce to 3 mg/kg/day as soon as clinically indicated. Children: 2-2.5 mg/kg every 8 hr. Infants/Neonates: 2.5 mg/kg every 8 hr. 1 wk or less: 2.5 mg/kg every 12 hr.
One of the following licensed pharmacy from the nearest location will deliver Refobacin Injection 20 mg 5 Ampx1 mL. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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