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Information on this page was last modified on : 2021/05/16 8:06:34 PM

Refobacin Injection 80 mg 5 Ampx2 mL

Belongs to Category,

Refobacin Injection contains Gentamicin, Inj | belongs to Aminoglycoside

Alternate brands of Refobacin Injection 80 mg 5 Ampx2 mL

Brand Name Price Savings
Skycin Injection 20 mg 5 Ampx2 mL  44.00 You can save 98.78
Skycin Injection 80 mg 5 Ampx2 mL  80.00 You can save 62.78
SG Injection 80 mg 5 Ampx2 mL  99.35 You can save 43.43
SG Injection 40 mg 5 Ampx2 mL  60.00 You can save 82.78
SG Injection 20 mg 5 Ampx2 mL  41.65 You can save 101.13
List of alternate brands

How it works

It works by inhibiting the protein synthesis which is essential for the bacteria to grow.

Side effects

Major & minor side effects for Refobacin Injection 80 mg 5 Ampx2 mL

  • Abdominal pain severe
  • Agitation severe
  • Blurred vision severe
  • Changes in urine frequency severe
  • Hearing loss severe
  • Dizziness when getting up suddenly from a sitting position severe
  • Dry mouth severe
  • Fast heartbeat severe
  • Itching or rash severe
  • Increased salivation
  • Depression

Uses of Refobacin Injection 80 mg 5 Ampx2 mL

What is it prescribed for?

  • Bacteremia

    Refobacin Injection 80 mg 5 Ampx2 mL is used in the treatment of bacteremia which is an infection of the blood caused by Staphylococci and Streptococcus pyogenes.

  • Intraabdominal Infection

    Refobacin Injection 80 mg 5 Ampx2 mL is used in the treatment of intra-abdominal infections caused by Helicobacter pylori, Staphylococci and Streptococci.

  • Bacterial Meningitis

    Refobacin Injection 80 mg 5 Ampx2 mLi s used in the treatment of meningitis, which is an inflammation of the protective membranes that surround the brain and spinal cord, caused by Streptococcus pneumoniae and Neisseria meningitidis.

  • Osteomyelitis

    Refobacin Injection 80 mg 5 Ampx2 mL is used in the treatment of bone and joint infections like Osteomyelitis caused by Staphylococci and Streptococci species.

  • Skin and Soft tissue infections

    Refobacin Injection 80 mg 5 Ampx2 mL is used to treat skin and soft tissue infections caused by Staphylococcus aureus and Streptococcus pyogenes.

  • Pyelonephriits

    Refobacin Injection 80 mg 5 Ampx2 mL is used in the treatment of Pyelonephritis which is a type of kidney infection caused by E.coli, Pseudomonas aeruginosa, Enterococci and Klebsiella pneumoniae.

Concerns

Frequently asked questions

  • Onset of action

    The peak effect of this medicine can be observed in 30 to 90 minutes for an intramuscular injection and 30 minutes after an intravenous injection.

  • Duration of Effect

    The effect of this medicine lasts for an average duration of 6 to 8 hours.

  • Safe with Alchohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    No habit forming tendencies were reported.

  • Usage in pregnancy?

    This medicine is not recommended for pregnant women.

  • Usage while breast-feeding?

    Small amounts of this medicine is excreted in the human breast milk. Discuss with the doctor about benefits and risks. Monitoring of undesired effects like diarrhea, candidiasis is necessary.

When not to use?

  • Allergy

    Avoid if you have a known allergy to Refobacin Injection 80 mg 5 Ampx2 mL or any other aminoglycosides.

Warnings

Warnings for special population
  • Pregnancy

    This medicine is not recommended for pregnant women.

  • Breast-feeding

    Small amounts of this medicine is excreted in the human breast milk. Discuss with the doctor about benefits and risks. Monitoring of undesired effects like diarrhea, candidiasis is necessary.

General Warnings
  • Hearing loss

    Refobacin Injection 80 mg 5 Ampx2 mL is not recommended in the patients with existing kidney injury or hearing problem it may increase the risk of deafness.

  • Impaired kidney function

    Refobacin Injection 80 mg 5 Ampx2 mL may increase the risk of kidney injury especially when high doses are used or when the treatment prolongs for a longer time. Suitable dose adjustments are to be made based on the CrCl.

  • Neuromuscular disorders

    Refobacin Injection 80 mg 5 Ampx2 mL is not recommended in the patients with existing neuromuscular diseases like Parkinson's disease.

  • Drug-resistance

    Usage of Refobacin Injection 80 mg 5 Ampx2 mL without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that is drug resistant.

Dosage

  • Missed Dose

    The missed dose can be taken as soon as you remember. However, the missed dose should be skipped if it is almost time for your next dose.

  • Overdose

    Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions

Interaction with Medicines
  • Furosemide severe
  • Nonsteroidal anti-inflammatory drugs moderate
  • Cephalosporins moderate
Disease interactions
  • severe

    Consume an adequate amount of water to prevent kidney injury and hearing problem. Fluid status should be monitored closely in the patients with severe diarrhea and vomiting. Frequent monitoring of kidney function tests is necessary. Dose adjustments are to be made based on the clinical condition.

Lab interactions

General Instructions

You should carefully follow all instructions on the label. The duration and amount of medicine consumed should be as prescribed by the doctor. It can be taken with food or after food. An adequate amount of water should be consumed to minimize the irritation caused in the stomach.

Other details

  • Can be taken with or without food, as advised by your doctor
  • To be taken as instructed by doctor
  • May cause sleepiness

References

Additional Information:

How to use Refobacin Injection 80 mg 5 Ampx2 mL

IM: Administer by deep IM route if possible. Slower absorption and lower peak concentrations, probably due to poor circulation in the atrophic muscle, may occur following IM injection; in paralysed patients, suggest IV route. IV: Administer other antibiotics at least 1 hour before or 1 hour after gentamicin.
Compatibility: Stable in dextran 40, D5W, D10W, mannitol 20%, LR, NS. Incompatible with fat emulsion 10%.
Y-site administration:
Drug to Drug IV Compatibility: Acyclovir, amikacin, amiodarone, aztreonam, bumetanide, calcium gluconate, ciprofloxacin, cisatracurium, diltiazem, diphenhydramine, dobutamine, dopamine, enalapril, epinephrine, esmolol, famotidine, fentanyl, fluconazole, hydromorphone, imipenem, labetalol, lansoprazole, levofloxacin, linezolid, lorazepam, magnesium sulphate, meropenem, methylprednisolone, metoclopramide, midazolam, milrinone, morphine, nitroglycerin, nitroprusside, norepinephrine, ondansetron, phenylephrine, ranitidine, tobramycin, vancomycin, vasopressin, vecuronium.
Drug to Drug IV Incompatibility: Allopurinol, amphotericin B cholesteryl sulphate complex, azithromycin, cefamandole, dexamethasone, furosemide, heparin, hetastarch, hydrocortisone, idarubicin, indomethacin, iodipamide meglumine, phenytoin, propofol, warfarin.
In syringe: Incompatible with ampicillin, cefamandole, heparin.
When admixed: Incompatible with amphotericin B, ampicillin, cefamandole, cephazolin with clindamycin, cefepime, heparin, nafcillin, ticarcillin.
Stability: It should be stored between 2°C-30°C, but refrigeration is not recommended. For reconstituted solution (IV infusion mix in NS or D5W solution) are stable for 24 hours at room temperature and refrigeration.

what are the adverse effects of Refobacin Injection 80 mg 5 Ampx2 mL?

Vestibular and auditory damage, nephrotoxicity, hypomagnesaemia, blood dyscrasias, purpura, nausea, vomiting, stomatitis, signs of liver dysfunction, antibiotic associated colitis, atrophy at injection site, ototoxicity, neuromuscular blockade.

What happens if I miss a dose of Refobacin Injection 80 mg 5 Ampx2 mL?

Adults: Up to 5 mg/kg IM or IV daily in three divided doses for 7-10 days. Children: Up to 2 wk, 3 mg/kg twelve hourly; over 2 wk, 2 mg/kg eight hourly. Both IM or IV for 7-10 days.
Bone Infection: IM/IV: Adults: 3 mg/kg/day given every 8 hr. Max: 5 mg/kg/day in 3-4 doses. Reduce to 3 mg/kg/day as soon as clinically indicated. Children: 2-2.5 mg/kg every 8 hr. Infants/Neonates: 2.5 mg/kg every 8 hr. 1 wk or less: 2.5 mg/kg every 12 hr.
Lower Respiratory Infection & Meningitis & Septicaemia: IV: Adults: 3 mg/kg/day given every 8 hr. Max: 5 mg/kg/day in 3-4 doses. Reduce to 3 mg/kg/day as soon as clinically indicated. Children: 2-2.5 mg/kg every 8 hr. Infants/Neonates: 2.5 mg/kg every 8 hr. 1 wk or less: 2.5 mg/kg every 12 hr.

One of the following licensed pharmacy from the nearest location will deliver Refobacin Injection 80 mg 5 Ampx2 mL. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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