Sandimmun Injection 250 mg 10 Ampx5 mL

How to use Sandimmun Injection 250 mg 10 Ampx5 mL

For IV infusion only. Administer as a slow IV infusion over approximately 2-6 hours.
Reconstitution: Immediately before use, dilute 1 mL of cyclosporine IV concentrate in 20-100 mL of NaCl 0.9% injection or dextrose 5% injection.
Stability: Store at temperature below 30°C (86°F) and protect from light. Discard diluted infusion solutions after 24 hours.

what are the adverse effects of Sandimmun Injection 250 mg 10 Ampx5 mL?

Hyperlipidaemia, hyper-uricaemia, hyperkalaemia, hypomagnesaemia, tremor, headache, paraesthesia, hypertension (discontinue if cannot control), GI upset, anorexia, abdominal pain, gingival hypertrophy, hepatic and renal dysfunction, hypertrichosis, muscle cramps, myalgia, fatigue, anaemia, thrombocytopenia, signs of encephalopathy, rash, oedema, weigh gain, malignancies, Iymphoproliferative disorders, infections. Rarely, micro-angiopathic Haemolytic anaemia or haemolytic uraemic syndrome, menstrual disturbances, gynaecomastia, hyperglycaemia, motor polyneuropathy, pancreatitis, muscle weakness, myopathy, optic disc oedema. Risk of benign intracranial hypertension; investigate patients presenting with signs of raised intracranial pressure, withdraw cyclosporin if diagnosed.

What happens if I miss a dose of Sandimmun Injection 250 mg 10 Ampx5 mL?

Organ transplantations: Used alone, Adults & Children over 3 mth: 10-15 mg/kg by mouth 4-12 yr before transplantations followed by 10-15 mg/kg daily for 1-2 wk postoperatively then reduced gradually to 2-6 mg/kg daily for maintenance (dose should be adjusted according to blood-cyclosporin concentration and renal function); dose lower if given concomitantly with other immunosuppressant therapy; if necessary one-third corresponding oral dose can be given by IV infusion over 2-6 hr. Bone marrow transplantation; prophylaxis and treatment of graft versus-host disease: Adults & Children over 3 mth: 3-5 mg/kg daily by IV infusion over 2-6 hr from day before transplantation to 2 wk postoperatively (or 12.5-15 mg/kg daily by mouth) then 12.5 mg/kg daily by mouth for 3-6 mth then tailed off (may take up to a yr after transplantation). Nephrotic syndrome: Adults: Orally, 5 mg/kg daily in 2 divided doses. Children: 6 mg/kg daily in 2 divided doses. Atopic dermatitis: Adults: Orally, initially 2.5 mg/kg daily in 2 divided doses, if good initial response not achieved within 2 wk. Increase rapidly to max 5 mg/kg daily; initial dose of 5 mg/kg daily in 2 divided doses if very severe. Children: Not recommended. Severe psoriasis: Adults: Orally, initially 2.5 mg/kg daily in 2 divided doses, increase gradually to max 5 mg/kg daily if no improvement within 1 mth (discontinue if response still insufficient after 6 wk); initial dose of 5 mg/kg daily justified if condition requires rapid improvement. Children: Not recommended. Severe arthritis: Adults: Orally, initially 2.5 mg/kg daily in 2 divided doses, if necessary increased gradually after 6 wk; max 4 mg/kg daily (discontinue if response insufficient after 3 mth); dose adjusted according to response for maintenance and treatment reviewed after 6 mth. Children: Not recommended.

One of the following licensed pharmacy from the nearest location will deliver Sandimmun Injection 250 mg 10 Ampx5 mL. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.