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Semidine tablet 400 mg 100's

Semidine tablet contains Cimetidine | belongs to H2 blocker

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How it works

Semidine tablet 400 mg 100’s works by blocking histamine at a specific site in the stomach. This results in inhibition of acid secretion and lowered gastric acidity.

Side effects

Major & minor side effects for Semidine tablet 400 mg 100’s

  • Headache severe
  • Dizziness severe
  • Diarrhea severe
  • Gynecomastia severe
  • Decrease in blood cell count severe
  • Skin rash
  • Muscle pain
  • Sleepiness
  • Joint pain

Uses of Semidine tablet 400 mg 100’s

What is it prescribed for?

  • Duodenal Ulcer

    Semidine tablet 400 mg 100’s is used in the treatment of ulcers in the small intestine.

  • Gastric Ulcer

    Semidine tablet 400 mg 100’s is used in the treatment of ulcers in the stomach.

  • Gastroesophagal Reflux Disease

    Semidine tablet 400 mg 100’s is used for the treatment of a condition where the acid produced in the stomach causes irritation in the food pipe.

  • Zollinger-Ellison Syndrome

    Semidine tablet 400 mg 100’s is used to relieve the symptoms of this rare condition where the acid secretion in the stomach is abnormally high.

Concerns

Frequently asked questions

  • Onset of action

    The effect of this medicine can be observed in less than 1 hour after an oral dose and less than 30 minutes after an intravenous dose.

  • Duration of Effect

    The effect of this medicine lasts for an average duration of 4 to 5 hours after an intravenous dose and 4 to 8 hours after an oral dose.

  • Safe with Alchohol?

    Consumption of alcohol is not recommended in patients receiving Semidine tablet 400 mg 100’s. Any symptoms of adverse effects like dizziness, breathing difficulty should be reported to the doctor. Performing activities that require mental alertness like driving, operating machinery should be avoided.

  • Is it habit forming?

    No habit forming tendencies were reported.

  • Usage in pregnancy?

    This medicine is recommended in pregnant women only if benefits overweigh the risks.

  • Usage while breast-feeding?

    This medicine is known to excreted through the breastmilk. It is not recommended for breastfeeding women.

When not to use?

  • Allergy

    Not recommended in patients with known allergy to Semidine tablet 400 mg 100’s or other H2 antagonists.

Warnings

Warnings for special population
  • Pregnancy

    This medicine is recommended in pregnant women only if benefits overweigh the risks.

  • Breast-feeding

    This medicine is known to excreted through the breastmilk. It is not recommended for breastfeeding women.

Warnings

Warnings for special population
  • Kidney disease

    This medicine should be used with caution in patients with the kidney injury due to the risk of interstitial nephritis and urinary retention. Close monitoring of kidney function is necessary. The dose of this medicine should be adjusted based on the CrCl.

  • Use in children

    This medicine is recommended for children less than 16 years only if benefits overweigh the risks.

  • Liver disease

    This medicine should be used with caution in patients with liver disease. Any signs and symptoms of elevated liver enzymes, fatigue, abdominal pain, and dark urine should be reported to the doctor.

  • Gastric malignancy

    This medicine may relieve the symptoms of gastric cancer but do not treat the condition. Early diagnosis of malignancy is necessary and appropriate treatment should be initiated.

Dosage

  • Missed Dose

    Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped.

  • Overdose

    Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions

Interaction with Medicines
  • Glipizide moderate
  • Loperamide severe
  • Phenytoin severe
  • Antifungal agents moderate
Disease interactions
  • severe

    Use of Semidine tablet 400 mg 100’s is not recommended for use if any symptoms indicating gastrointestinal bleeding exists. Consult your doctor if there is blood in vomit or the stools are bloody or black.

General Instructions

Take Semidine tablet 400 mg 100’s once a day with meals and at bedtime or as prescribed by the doctor. It can be taken 30 minutes before food to prevent symptoms of heartburn. Do not take in larger amounts than prescribed. Take this medicine at the same time every day.

Other details

  • Can be taken with or without food, as advised by your doctor
  • To be taken as instructed by doctor
  • May cause sleepiness

References

How to use Semidine tablet 400 mg 100’s

IV: May be administered as a slow IV push or preferably as an IV intermittent or IV continuous infusion. Administer each 300 mg (or fraction thereof) over a minimum of 5 min when giving IV push. Give intermittent infusion over 15-30 min for each 300 mg dose. Intermittent infusions are administered over 15-30 min at a final concentration not to exceed 6 mg/ mL; for patients with an active bleed, preferred method of administration is continuous infusion.
Compatibility: Stable in D5LR, D5 ¼ NS, D5 ½ NS, D5W, LR, sodium bicarbonate 5%.
Y-site administration:
Drug to Drug IV Compatibility: Acyclovir, aztreonam, cisatracurium, dexamethasone, digoxin, diltiazem, diphenhydramine, dobutamine, enalapril, epinephrine, esmolol, fentanyl, fluconazole, furosemide, heparin, hydromorphone, labetalol, levofloxacin, linezolid, lorazepam, meropenem, methylprednisolone, metoprolol, metronidazole, midazolam, milrinone, morphine, nitroprusside, ondansetron, piperacillin/tazobactam, propofol, vancomycin, vecuronium.
Drug to Drug IV Incompatibility: Allopurinol, amikacin, amphotericin B cholesteryl sulphate complex, amsacrine, cefepime, indomethacin, warfarin.
In syringe: Incompatible with atropine/pentobarbital, cefamandole, cephazolin, chlorpromazine, ioxaglate meglumine and ioxaglate sodium, pentobarbital, secobarbital.
When admixed: Incompatible with amphotericin B, barbiturates.
Stability: Intact vials should be stored at room temperature & protected from light. Stability at room temperature for prepared bags is 7 days. Stable in parenteral nutrition solutions for up to 7 days when protected from light.

what are the adverse effects of Semidine tablet 400 mg 100’s

Diarrhoea, dizziness, rash, tiredness. Gynaecomastia, occasional reversible liver damage, confusion. Very rarely interstitial nephritis, acute pancreatitis, thrombocytopenia, leucopenia, pancytopenia, aplastic anaemia, fever, headache, myalgia, arthralgia, sinus bradycardia, tachycardia, heart block, anaphylaxis, hallucinations, depression, reversible impotance.

What is the dose of Semidine tablet 400 mg 100’s

TABLET: Adults: Active duodenal ulcer: Single dose of 800 mg at bed time or 400 mg at breakfast and 400 mg at bed time, or 200 mg three times a day with meals and 400 mg at bedtime.
Reflux oesophagitis: 400 mg four times a day with meals and at bedtime for upto 12 wk is indicated.
Zollinger-Ellison syndrome and other cases of high gastric secretion: 200 mg 3 times a day with meals and 400 mg at bedtime.
Acid related dyspepsia: 200 mg 4 times a day (with meals and at bed time).
In haemorrhage from ulceration or erosion of upper Gl tract, stress ulcers: 200 mg three times daily with meals and 400 mg at bedtime.
In non- ulcer acid related conditions: 200 mg 4 times a day (with meals and at bed time).
Children: Over 1 yr, 25-30 mg/kg daily in divided doses.
INJECTION: Adults: IM 200 mg may be repeated at 4-8 hourly intervals. IV: Intermittent infusion: 400 mg diluted in 100 mL dextrose 5% injection, infusion time not less than 30 min. Total dosage in 24 hr should not exceed 6 infusions or 2400 mg. IV: 200 mg diluted in 0.9% NaCl total volume of 20 mL to be given slowly over a period of 2 min, to be repeated 4-6 hourly. Children: IM or IV: 20-40 mg/kg/day in divided doses every 6 hr.
SUSPENSION: Adults: 10 mL twice daily after breakfast and at bed time.
Children: Under 1 yr, not recommended; over 1 yr, 25-30 mg/kg daily in divided doses.

One of the following licensed pharmacy from the nearest location will deliver Semidine tablet 400 mg 100’s. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts the your request based on valid prescription and availability.

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