Silo-M tablet 50/1000 mg 14’s


Manufactured by:
Active Pharmaceutical Ingredient:
Drug Strength: 50/1000 mg
Drug Form : Tablet
Pack Size : 14s
Does this requires a prescription ?Yes

Silo-M tablet contains Sitagliptin and Metformin | belongs to Biguanide/Dipeptidyl peptidase-4 inhibitor

SKU: pg_21169_29326 Categories: ,

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    How it works

    Silo-M tablet 50/1000 mg 14’s works to competitively inhibit the enzyme dipeptidyl peptidase 4 (DPP-4). This enzyme breaks down the incretins GLP-1 and GIP, gastrointestinal hormones released in response to a meal.[19] By preventing breakdown of GLP-1 and GIP, they are able to increase the secretion of insulin and suppress the release of glucagon by the alpha cells of the pancreas. This drives blood glucose levels towards normal. As the blood glucose level approaches normal, the amounts of insulin released and glucagon suppressed diminishes, thus tending to prevent an "overshoot" and subsequent low blood sugar (hypoglycemia), which is seen with some other oral hypoglycemic agents.


    Frequently asked questions

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    • Duration of Effect

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    • Usage in pregnancy?

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    • Missed Dose

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    Additional Information>

    what are the adverse effects of Silo-M tablet 50/1000 mg 14’s?

    Metformin: GI upset, taste disturbance, rarely lactic acidosis, abnormal liver function tests, hepatitis, skin reactions, reduced B12 absorptions.
    Sitagliptin: Reports of pancreatitis and serious hypersensitivity reactions, including anaphylaxis and Stevens-Johnson syndrome. Hypoglycaemia, headache, bullous pemphigoid. Monotherapy: Osteoarthritis, pain in extremity, upper RTI. With metformin: GI upset. With a glitazone: Flatulence, peripheral oedema. With insulin: Influenza.

    What happens if I miss a dose of Silo-M tablet 50/1000 mg 14’s?

    Adults: Initially, 50 mg/500 mg or 50 mg/1000 mg twice daily based on dose of metformin already being taken. For patients receiving components as separate tab, switch to equivalent dose. Doses of sulfonylurea or insulin may need to be reduced. Max daily dose of sitagliptin, 100 mg. Children: Not recommended.

    One of the following licensed pharmacy from the nearest location will deliver Silo-M tablet 50/1000 mg 14’s. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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