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Skif capsule 150 mg 1's

Belongs to Category

Skif capsule contains Fluconazole | belongs to Triazole antifungal

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How it works

Skif capsule 150 mg 1’s acts by stopping the production of a certain vital component for the fungi. This results in disruption of cell membrane formation process and growth of the organism are stunted.

Side effects

Major & minor side effects for Skif capsule 150 mg 1’s

  • Headache severe
  • Nausea and Vomiting severe
  • Abdominal pain
  • Diarrhea
  • Skin rash
  • QT Prolongation severe
  • Alopecia
  • Seizures severe
  • Swelling of face, lips, eyelids, tongue, hands and feet

Uses of Skif capsule 150 mg 1’s

What is it prescribed for?

  • Oropharyngeal Candidiasis

    Skif capsule 150 mg 1’s is used to treat fungal infection in the mouth.

  • Esophageal Candidiasis

    Skif capsule 150 mg 1’s is used to treat the fungal infection of the oesophagus or the "food pipe" causing odynophagia or painful swallowing.

  • Cryptococcal Meningitis

    Skif capsule 150 mg 1’s is used to treat meningitis, a rare infection that affects the delicate membranes called meninges that covers the brain and spinal cord, caused by a group of fungi of Cryptococcus strain.

  • Vaginal Candidiasis

    Skif capsule 150 mg 1’s is used to treat yeast infection in the female genital organ causing pain, itching and burning sensation with unusual discharge.

  • Urinary Tract Infection

    Skif capsule 150 mg 1’s is used to treat fungal infections of the urinary tract.

  • Peritonitis

    Skif capsule 150 mg 1’s is used to treat the fungal infection that causes inflammation of the peritoneum, a thin layer of tissue that covers the inside of the abdomen and most of the organs present within the abdomen.

  • Candidemia

    Skif capsule 150 mg 1’s is used to treat Candidemia, a condition in which the fungus Candida enters the bloodstream and from the blood to eyes, kidneys, liver and brain causing Invasive candidemia.

  • Prophylaxis of Infections in Special Population

    Prophylaxis of Infections in Special Population

Concerns

Frequently asked questions

  • Onset of action

    The effect of this medicine can be observed within 1-2 hours of oral administration.

  • Duration of Effect

    The effect of this medicine can be observed within 1-2 hours of oral administration.

  • Safe with Alchohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    No habit forming tendencies were reported.

  • Usage in pregnancy?

    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before using this medicine.

  • Usage while breast-feeding?

    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If you use the medicine, you are advised to monitor the baby closely for any adverse effects.

When not to use?

  • Allergy

    Skif capsule 150 mg 1’s is not recommended for use if you have a known allergy to this medicine.

  • QT Interval prolonging drugs

    Skif capsule 150 mg 1’s is not recommended for co-administration with drugs that are known to cause specific changes in heart rhythm.

Warnings

Warnings for special population
  • Pregnancy

    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before using this medicine.

  • Breast-feeding

    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If you use the medicine, you are advised to monitor the baby closely for any adverse effects.

Warnings

Warnings for special population
  • Liver Injury

    Skif capsule 150 mg 1’s can cause moderate to severe side effects on liver and may result in liver failure in rare cases. Any known incidence of liver disease should be reported to the doctor. Dosage adjustments and safety monitoring might be required in such cases.

  • Allergy

    Skif capsule 150 mg 1’s and other medicines of the same group i.e Azoles could cause allergy in some patients. Any such known instance of allergy should be reported to the doctor.

  • Skin disorders

    Skif capsule 150 mg 1’s may cause a condition where the skin starts to peel off in some patients. If you have had fungal infections in the past, then symptoms of infections should be monitored closely.

  • Heart condition

    Caution is advised while using this medicine in patients with a history of cardiovascular disorder. Suitable dose adjustment and safety monitoring might be required in such cases.

  • Kidney disease

    It is recommended to report any history of or active renal disorders to the doctor prior to the start of therapy with this medicine as necessary dosage adjustments may be made by the doctor for the safe use of this medicine.

  • Dizziness and seizures

    This medicine may cause dizziness or even seizures in few patients. Hence caution is adviced while driving and operating heavy machinery after taking this medicine.

  • Other drugs and supplements

    Skif capsule 150 mg 1’s is known to interact with a large number of other medicines and hence it becomes mandatory for you to report the use of all of them to the doctor.

  • Birth control

    Skif capsule 150 mg 1’s may interact with the birth control pill you might be consuming and hence contraception might be ineffective. Alternate means of birth control are to be adopted while you are taking this medicine.

  • Geriatric use

    Skif capsule 150 mg 1’s must be used with caution in elderly since the effects are more severe, warranting an adjustment in dosage.

Dosage

  • Missed Dose

    Oral and topical forms: The missed dose of Skif capsule 150 mg 1’s should be taken/used as soon as possible. It is advisable to skip the missed dose if it is already the time for your next scheduled dose. Do not double the dose to make up for the missed one. Since Fluconazole injection is mostly administered by a healthcare professional in a clinical setting, the likelihood of missing a dose is very low.

  • Overdose

    Oral and Topical forms: Seek emergency medical attention or contact your doctor in case of an overdose with Fluconazole. Injection: Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.

Interactions

Interaction with Medicines
  • Alprazolam severe
  • Atorvastatin severe
  • Cisapride severe
  • Clopidogrel severe
  • Erythromycin severe
  • Warfarin moderate
  • Tretinoin moderate
Disease interactions
  • severe

    Skif capsule 150 mg 1’s should be carefully administered in patients with impaired hepatic function. Suitable dosage adjustments and safety monitoring are necessary in such cases.

  • moderate

    Skif capsule 150 mg 1’s should be very carefully administered in patients with pre-existing heart conditions. Suitable dosage adjustments and safety monitoring are recommended in such cases.

  • moderate

    Skif capsule 150 mg 1’s should be carefully administered in patients with impaired kidney function. Suitable dosage adjustments and safety monitoring are necessary in such cases.

Lab interactions

General Instructions

Skif capsule 150 mg 1’s should be taken following all the instructions that are given by your doctor. To ensure complete recovery and no relapse, the full course of treatment should be followed. It is more effective if taken at the same time on all days. Any instance of side effect should be reported to the doctor immediately.

Other details

  • Can be taken with or without food, as advised by your doctor
  • To be taken as instructed by doctor
  • May cause sleepiness

References

How to use Skif capsule 150 mg 1’s

IV: Fluconazole be administered by IV Infusion over approx 1-2 hours; do not exceed 200 mg/hour when giving IV Infusion. Standard diluent: 200 mg/100 mL NS (premixed); 400 mg/200 mL NS (premixed).
Compatibility: Stable in D5W, LR, NS.
Y-site administration:
Drug to Drug IV Compatibility: Acyclovir, amikacin, amiodarone, aztreonam, bumetanide, cephazolin, cefepime, cimetidine, ciprofloxacin, cisatracurium, dexamethasone, diltiazem, diphenhydramine, dobutamine, dopamine, enalapril, epinephrine, esmolol, famotidine, fentanyl, gentamicin, heparin, hydrocortisone, hydromorphone, insulin regular, labetalol, lansoprazole, levofloxacin, linezolid, lorazepam, magnesium sulphate, meropenem, methylprednisolone, metoclopramide, metronidazole, midazolam, morphine, nitroglycerin, nitroprusside, norepinephrine, ondansetron, phenylephrine, piperacillin/tazobactam, propofol, ranitidine, tobramycin, vancomycin, vasopressin, vecuronium.
Drug to Drug IV Incompatibility: Amphotericin B, amphotericin B cholesteryl sulphate complex, ampicillin, calcium gluconate, cefoxitin, ceftazidime, ceftriaxone, cefuroxime, chloramphenicol, clindamycin, co-trimoxazole, diazepam, digoxin, erythromycin lactobionate, furosemide, haloperidol, hydroxyzine, imipenem/cilastatin, pantoprazole, pentamidine, piperacillin, ticarcillin.
When admixed: Incompatible with co-trimoxazole.
Stability: Store vial at 5°C-30°C. Do not freeze. Do not unwrap until ready for use.

what are the adverse effects of Skif capsule 150 mg 1’s

GI upset, headache, rash, altered LFTs. Reports of Stevens-Johnson syndrome and toxic epidermal necrolysis (discontinue).

What is the dose of Skif capsule 150 mg 1’s

Vaginal candidiasis and candidal balanitis: Adults: Orally, a single dose of 150 mg.
Mucosal candidiasis (except genital): Adults: Orally, 50 mg daily (100 mg daily in unusually difficult infections) given for 7-14 days in oropharyngeal candidiasis (max 14 days except in severely immunocompromised patients); for 14 days in atrophic oral candidiasis associated with dentures; for 14-30 days in other mucosal infections (e.g. oesophagitis, candiduria, non-invasive bronchopulmonary infections). Children: Orally or by IV infusion, 3-6 mg/kg on first day then 3 mg/kg daily (every 72 hr in neonates up to 2 wk old, every 48 hr in neonates of 2-4 wk old).
Tinea pedis, corporis, cruris, versicolor and dermal candidiasis: Adults: Orally 50 mg daily for 2-4 wk (for up to 6 wk in tinea pedis); max duration of treatment 6 wk.
Invasive candidal infections (including candidaemia and disseminated candidiasis) and cryptococcal infections (including meningitis), Orally or IV Infusion, 400 mg on first day then 200-400 mg daily; max 800 mg daily in severe infections. (unlicensed dose); treatment continued according to response (at least 8 weeks for cryptococcal meningitis); Children: 6-12 mg/kg daily (every 72 hrs in neonates up to 2 weeks old, every 48 hrs in neonate 2-4 weeks old); max. 800 mg daily (unlicensed dose).
Prevention of relapse of cryptococcal meningitis in AIDS patients after completion of primary therapy: Adults: Orally 100-200 mg daily.
Prevention of fungal infections in immunocompromised patients following cytotoxic chemotherapy or radiotherapy: Adults: Orally or by IV infusion 50-400 mg daily adjusted according to risk; 400 mg daily if high risk of systemic infections e.g. following bone-marrow transplantation; commence treatment before anticipated onset of neutropenia and continue for 7 days after neutrophil count in desirable range. Children: According to extent and duration of neutropenia, 3-12 mg/kg daily (every 72 hr in neonates up to 2 wk old, every 48 hr in neonates of 2-4 wk old); max. 400 mg daily.

One of the following licensed pharmacy from the nearest location will deliver Skif capsule 150 mg 1’s. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts the your request based on valid prescription and availability.

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