Solu-Cortef Injection 500 mg 1 Vial
Solu-Cortef Injection contains Hydrocortisone Sodium Succinate | belongs to Glucocorticoid
How it works
Solu-Cortef Injection 500 mg 1 Vial weakens your immune system's response to various diseases to reduce symptoms such as swelling and allergic-type reactions.
Frequently asked questions
Onset of action
Duration of Effect
Safe with Alchohol?
Is it habit forming?
Usage in pregnancy?
Usage while breast-feeding?
- webmd.com - Hydrocortisone Sodium Succinate [Internet]. Available from: https://www.webmd.com/drugs/2/drug-6829/hydrocortisone-sodium-succinate-injection/details [cited 2/7/2020].
Hydrocortisone sodium succinate may be administered by IM or IV. UNLICENSED USE
How to use Solu-Cortef Injection 500 mg 1 Vial
IV bolus: Dilute to 50 mg/mL and give over 30 seconds to several min.
IV intermittent infusion: Dilute to 1 mg/mL and give over 20-30 min.
Compatibility: Stable in NS, D5W, fat emulsion 10%, LR, 1/2NS.
Drug to Drug IV Incompatibility: Ciprofloxacin, diazepam, ergotamine, idarubicin, midazolam, phenytoin, sargramostim.
In syringe: Incompatible with doxapram.
When admixed: Incompatible with aminophylline with cephalothin, bleomycin, ephedrine, hydralazine, naphcillin, pentobarbital, phenobarbital, prochlorperazine edisylate, promethazine.
Stability: Store unreconstituted product and solution at 20°C-25°C (68°F-77°F). Protect from light. Use solution only if it is clear. Unused solution should be discarded after 3 days.
Congenital adrenal hyperplasia: Children: Oral: Neonate, 9-15mg/square meter in 3 divided doses, adjusted according to response; 1 mth-18 yr, 9-15 mg/square meter in 3 divided doses, adjusted according to response. Adults: Oral: 15-25 mg/day in 2-3 divided doses.
Physiologic replacement: Adults: Oral: 15-25 mg/day in 2-3 divided doses. One-half to two-thirds of the daily dose in the morning in order to mimic the physiological cortisol secretion pattern. If the twice-daily regimen is utilized, the sec dose should be administered 6-8 hr following the first dose.
Septic shock: IV: Adults: 50 mg every 6 hr, not to exceed 300 mg/day. Alternative dosing of 100 mg bolus, followed by continuous infusion of 10 mg/hr (240 mg/day). Taper slowly (for total of 11 days) and do not stop abruptly. Children: Initial 1-2 mg/kg/day by intermittent or continuous infusion; may titrate up to 50 mg/kg/day for shock reversal. Use recommended only in catecholamine-resistant shock and suspected or proven adrenal insufficiency.
Thyroid storm: IV: Adults: 300 mg loading dose, followed by 100 mg every 8 hr.
Hydrocortisone sodium succinate may be administered by IM or IV.
what are the adverse effects of Solu-Cortef Injection 500 mg 1 Vial?
Endocrine irregularities including menstrual problems, Cushingoid state, adrenal suppression, growth suppression in children. Increased susceptibility to infection, increased severity of infection. Fluid/electrolyte disturbance, hypertension, negative protein, nitrogen and calcium balance. Myopathy, tendon rupture, osteoporosis, osteonecrosis and fractures. Impaired wound healing, sweating, hirsutism, striae, telangiectasia, acne. GI disturbance, peptic ulceration, acute pancreatitis, candidiasis. Psychiatric effects, neurological effects, insomnia. Diabetes, impaired glucose tolerance, weight gain, increased appetite. Ocular disturbances including cataracts, raised intraocular pressure, optic nerve damage, corneal changes, glaucoma. Thromboembolism, leukocytosis.
What happens if I miss a dose of Solu-Cortef Injection 500 mg 1 Vial?
Dose should be based on severity of disease and patient response.
Adults: Adrenal insufficiency (acute): 100 mg IV bolus, then 300 mg/day in divided doses every 8 hr or as a continuous infusion for 48 hr; once patient is stable change to oral, 50 mg every 8 hr for 6 doses, then taper to 30-50 mg/day in divided doses.
Adrenal insufficiency (chronic): Oral: 15-25 mg/day in 2-3 divided doses. One-half to two-thirds of the daily dose in the morning in order to mimic the physiological cortisol secretion pattern. If the twice-daily regimen is utilized, the sec dose should be administered 6-8 hr following the first dose.
Anti-inflammatory or immunosuppressive: Oral/IM/IV: 15-240 mg every 12 hr.
Status asthmaticus: IV: 1-2 mg/kg/dose every 6 hr for 24 hr, then maintenance of 0.5-1 mg/kg every 6 hr.
Stress dosing (surgery) in patients known to be adrenally-suppressed or on chronic systemic steroids: IV: Minor stress (inguinal herniorrhaphy): 25 mg/day for 1 day. Moderate stress (joint replacement, cholecystectomy): 50-75 mg/day (25 mg every 8-12 hr) for 1-2 days. Major stress (pancreatoduodenectomy, oesophagogastrectomy, cardiac surgery): 100-150 mg/day (50 mg every 8-12 hr) for 2-3 days.
Children: Acute adrenocortical insufficiency (Addisonian crisis): IV: Neonate, initially 10 mg by slow IV injection then 100 mg/ square meter daily by continuous IV infusion or in divided doses every 6-8 hr; adjusted according to response; when stable reduce over 4-5 days to oral maintenance dose; 1 mth-12 yr, initially 2-4 mg/kg by slow IV injection or infusion then 2-4 mg/kg every 6 hr; adjusted according to response; when stable reduce over 4-5 days to oral maintenance dose; 12-18 yr, 100 mg every 6 to 8 hr by slow IV injection or infusion.
Adrenal hypoplasia, Addison’s disease, chronic maintenance or replacement therapy: Oral: Neonate, 8-10 mg/ square meter daily in 3 divided doses, higher doses may be needed; 1 mth-18 yr, 8-10mg/ square meter daily in 3 divided doses; higher doses may be needed. Give larger doses in the morning and smaller doses in the evening.
Inflammatory bowel disease, induction of remission: IV injection: 2-18 yr, 2.5 mg/kg (max 100 mg) every 6 hr. IV infusion: 2-18 yr, 10 mg/kg daily (max 400 mg daily).
Acute hypersensitivity reactions, angioedema: IM or IV injection: Under 6 mth, initially 25 mg 3 times daily, adjusted according to response; 6 mth-6 yr, initially 50 mg 3 times daily, adjusted according to response; 6-12 yr, initially 100 mg 3 times daily, adjusted according to response; 12-18 yr, initially 200 mg 3 times daily, adjusted according to response.
Hypotension resistant to inotropic treatment and volume replacement: IV injection: Neonate, initially 2.5 mg/kg repeated if necessary after 4 hr, then 2.5 mg/kg every 6 hr for 48 hr or until blood pressure recovers, then dose reduced gradually over at least 48 hr; 1 mth-18 yr, 1 mg/kg (max 100 mg) every 6 hr.
Rheumatic disease: Intra-articular injection: For details consult product literature. 1 mth-12 yr, 5-30 mg according to size of child and joint; 12-18 yr, 5-50 mg according to size of child and joint. Where appropriate may be repeated at intervals of 21 days; not more than 3 joints should be treated on any one day.
Severe acute asthma: IV: 4 mg/kg (max 100 mg) every 6 hr. If body weight not available, child under 2 yr, 25 mg; 2-5 yr, 50 mg; 5-18 yr, 100 mg. All every 6 hr. Change to maintenance oral therapy.
One of the following licensed pharmacy from the nearest location will deliver Solu-Cortef Injection 500 mg 1 Vial. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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