MBBS
Spinraza (Nusinersen) 12mg/5ml injection
Spinraza (nusinersen) is a prescription medication used to treat spinal muscular atrophy (SMA) in pediatric and adult patients. Each vial contains 12 mg of nusinersen in a 5 ml solution for intrathecal injection (injection into the spinal canal), designed to deliver the medication directly to the central nervous system.
How It Works
Nusinersen is an antisense oligonucleotide that targets and binds to a specific sequence of RNA, leading to increased production of survival motor neuron (SMN) protein. SMN protein is critical for the maintenance of motor neurons, and its deficiency is the underlying cause of SMA. By enhancing SMN protein levels, Spinraza helps improve motor function and slows the progression of SMA.
Side Effects
- Lower respiratory infections
- Constipation
- Headache
- Vomiting
- Back pain
- Post-lumbar puncture syndrome (headache, nausea, vomiting, dizziness)
- Increased risk of bleeding and bruising (thrombocytopenia)
Indications
- Treatment of spinal muscular atrophy (SMA) in pediatric and adult patients
Contraindications
- Known hypersensitivity to nusinersen or any of its components
Price in Different Countries
| Country | Price (USD) | Reference |
|---|---|---|
| United States | $125,000 per injection | GoodRx |
| Canada | $100,000 per injection | Canada Pharmacy |
| United Kingdom | £95,000 per injection | UK Meds |
| Australia | AUD 150,000 per injection | Australia Pharmacy |
| India | ₹9,000,000 per injection | India Meds |
Top 5 Global Brands
- Biogen – Manufacturer of Spinraza
- Novartis
- Roche
- Pfizer
- Sanofi
One of the following licensed pharmacy from the nearest location will deliver Spinraza (Nusinersen) 12mg/5ml injection. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.
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