Toposide Injection 100 mg 1 Vial

How to use Toposide Injection 100 mg 1 Vial

IV: Administer lower doses IVP Bolus over at least 30 min to minimize the risk of hypotensive reactions. At room temperature in D5W or NS in polyvinyl chloride, the concentration is stable as follows: 0.2 mg/mL: 96 hours; 0.4 mg/mL: 48 hours; 0.6 mg/mL: 8 hours; 1 mg/mL: 2 hours; 2 mg/mL: 1 hour; 20 mg/mL (undiluted): 24 hours.
Standard IV Dilution: Lower dose regimens (lt;1 gm/dose): Doses may be diluted in 100-1000 mL of D5W or NS. If the concentration is less than or equal to 0.6 mg/mL, the bag should be mixed with the appropriate expiration dating. If the concentration is gt;0.6 mg/mL, the concentration is highly unstable and a syringe of undiluted etoposide accompanied with the appropriate volume of diluent will be sent to the nursing unit to be mixed at the bedside just prior to administration. High-dose regimens (gt;1 gm/dose): Total dose should be drawn into an empty Viaflex container and the appropriate amount of diluent (for a final concentration of 1 mg/mL) will be sent. Use the 2-Channel Pump Method: Instill all of the etoposide dose into one container (concentration equal to 20 mg/mL). Infuse this into one channel. Infuse the indicated diluent (i.e., D5W of NS) at a rate of at least 20 times the infusion rate of the etoposide to simulate a 1 mg/mL concentration in the line. The etoposide should be Y-sited into the port most proximal to the patient. A 0.22 micron filter should be attached to the line after the Y-site and before entry into the patient.
Compatibility: Stable in D5W, LR.

what are the adverse effects of Toposide Injection 100 mg 1 Vial?

Myelosuppression, GI upset, anorexia, stomatitis, reversible alopecia, temporary hypotension, allergic reactions, hypertension & flushing, neuropathy.

What happens if I miss a dose of Toposide Injection 100 mg 1 Vial?

Adults: 60-120 mg/m² daily for 3-5 days followed by treatment-free interval of 14 days. Slow IV infusion over 1/2- 1 hr.

One of the following licensed pharmacy from the nearest location will deliver Toposide Injection 100 mg 1 Vial. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.