Tremfya Guselkumab 100mg Injection

How it Works

Tremfya, with the active ingredient guselkumab, is a monoclonal antibody used in the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy. Guselkumab selectively binds to the p19 subunit of interleukin-23 (IL-23) and inhibits its interaction with the IL-23 receptor. By blocking IL-23, guselkumab prevents the activation of Th17 cells and the subsequent release of inflammatory cytokines such as IL-17 and IL-22. This reduces inflammation and leads to improvement in psoriatic skin lesions.

Side Effects

• Upper respiratory tract infections
• Headache
• Injection site reactions (pain, erythema, bruising, itching)
• Nausea
• Fatigue
• Diarrhea
• Back pain
• Urinary tract infections
• Arthralgia (joint pain)
• Fungal skin infections
• Oral herpes

Indications

• Moderate to severe plaque psoriasis in adults who are candidates for systemic therapy

Contraindications

• Hypersensitivity to guselkumab or any of its excipients
• Active tuberculosis
• Active infection requiring systemic therapy

Price Comparison in Different Countries

Top 5 Global Brands

1. Tremfya (Janssen Biotech, Inc.)
2. Humira (AbbVie)
3. Stelara (Janssen Biotech, Inc.)
4. Enbrel (Amgen)
5. Cosentyx (Novartis)