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Information on this page was last modified on : 2020/06/26 4:18:39 PM

Ucefore Injection 1 gm 1 Vial

Belongs to Category,

Ucefore Injection contains Cefepime | belongs to Cephalosporin

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How it works

Ucefore Injection 1 gm 1 Vial is a broad spectrum antibiotic. It works by interfering with the bacterial cell wall synthesis.

Side effects

Major & minor side effects for Ucefore Injection 1 gm 1 Vial

  • Abdominal pain severe
  • Bleeding gums severe
  • Convulsions severe
  • Fever severe
  • Headache severe
  • Yellowing of skin and eyes severe
  • Swelling of foot severe
  • Diarrhea severe
  • Redness of skin
  • Pain at the injection site
  • Itching of vagina or genital area
  • Sour mouth

Uses of Ucefore Injection 1 gm 1 Vial

What is it prescribed for?

  • Pneumonia

    Ucefore Injection 1 gm 1 Vial is used in the treatment of community-acquired pneumonia which is a common type of lung infection caused by Streptococcus pneumoniae and Haemophilus influenzae.

  • Pyelonephriits

    Ucefore Injection 1 gm 1 Vial is used in the treatment of Pyelonephritis which is a type of kidney infection caused by E.coli, Pseudomonas aeruginosa, Enterococci and Klebsiella pneumoniae.

  • Skin and Soft tissue infections

    Ucefore Injection 1 gm 1 Vial is used to treat skin and soft tissue infections caused by Staphylococcus aureus and Streptococcus pyogenes.

  • Intra-abdominal Infection

    Ucefore Injection 1 gm 1 Vial is used in the treatment of intra-abdominal infections caused by Helicobacter pylori, Staphylococci and Streptococci.

Concerns

Frequently asked questions

  • Onset of action

    The peak effect of this medicine can be observed in 0.5 to 1.5 hours after an intravenous dose and 1 to 2 hours after an intramuscular dose.

  • Duration of Effect

    The effect of this medicine lasts for an average duration of 6 hours.

  • Safe with Alchohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    No habit forming tendency has been reported.

  • Usage in pregnancy?

    This medicine is not known to cause any harm to the fetus. But the evidence is inadequate and it should be used only when necessary after consulting a doctor.

  • Usage while breast-feeding?

    This medicine is safe to use during breastfeeding. Any incidence of rashes on skin or diarrhea in the infant should be reported. It is advised to consult a doctor before taking this medicine.

When not to use?

  • Allergy

    Avoid if you have a known allergy to Ucefore Injection 1 gm 1 Vial or any other Beta-lactam antibiotics like penicillins or cephalosporins.

Warnings

Warnings for special population
  • Pregnancy

    This medicine is not known to cause any harm to the fetus. But the evidence is inadequate and it should be used only when necessary after consulting a doctor.

  • Breast-feeding

    This medicine is safe to use during breastfeeding. Any incidence of rashes on skin or diarrhea in the infant should be reported. It is advised to consult a doctor before taking this medicine.

Warnings

Warnings for special population
  • Allergy

    Avoid taking this medicine if you have a known allergy to it or any other Beta-lactam antibiotics like penicillins and cephalosporins. Seek immediate medical attention if the patient experiences any allergic symptoms like rash, itching, nausea or vomiting, swelling of lips, hands, and feet.

  • Clostridium difficile-associated diarrhea

    Avoid if you experience severe diarrhea after receiving Ucefore Injection 1 gm 1 Vial As antibiotic therapy will cause an imbalance in the normal microbial flora in the large intestine which promotes the growth of bacteria called clostridium difficile.

  • Drug-resistance

    Usage of Ucefore Injection 1 gm 1 Vial without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that is drug resistant.

  • Impaired kidney function

    Use with caution if you have a preexisting kidney disease. Appropriate dose adjustments are to be made based of CrCl or eGFR.

  • Neurotoxicity

    Ucefore Injection 1 gm 1 Vial may increase the risk of serious adverse effects like encephalopathy, seizures, and nonconvulsive status epilepticus. These reactions may occur in the patients with impaired kidney function with no proper dose adjustment.

Dosage

  • Missed Dose

    The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

  • Overdose

    Seek emergency medical treatment or contact the doctor in case of overdose.

Interactions

Interaction with Medicines
  • Amikacin moderate
  • Ethinyl Estradiol moderate
  • Cholera severe
  • Furosemide moderate
Disease interactions
  • severe

    The blood concentration of intravenous Ucefore Injection 1 gm 1 Vial may increase in the patients suffering from impaired kidney function. Suitable dose adjustments are to be made based on the severity of the condition. Frequent monitoring of kidney function tests is necessary.

  • moderate

    Avoid if you experience severe diarrhea, abdominal pain, and blood in stools after taking Ucefore Injection 1 gm 1 Vial Inform the doctor if you are suffering from any gastrointestinal diseases. Drink adequate amount of water to prevent dehydration.

  • moderate

    Use with caution if you have any liver disease or a family history of liver disease. Regular liver function tests are to be performed. Inform the doctor if you have any liver disease or if you develop any undesired effect.

  • moderate

    Use with caution if you have any seizure disorder or a family history of seizures. Appropriate dose adjustments are to be made if you are suffering from a kidney disease. Discontinue if seizure is due to Ucefore Injection 1 gm 1 Vial Start with appropriate anticonvulsant medicine if it is clinically indicated.

General Instructions

Make sure that the medicine is dissolved properly. Do not take if any particulate matter is visible. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine before completion of course.

Other details

  • Usage does not depend on food timings
  • To be taken as instructed by doctor
  • May cause sleepiness

References

How to use Ucefore Injection 1 gm 1 Vial

IM: Inject deep IM large muscle mass. IV: Inject direct IV over 5 min. Infuse intermittent infusion over 30-60 min. IV Detail: pH 4-6.
Reconstitution: IV: Reconstitute using manufacturer’s guidelines. IM: Reconstitute 500 mg vial of drug with 1.3 mL of diluent, such as SWFI (or 1 gm vial with 2.4 mL of diluent).
Compatibility: Stable in D5LR, D5NS, D5W, D10W, NS, bacteriostatic water, SWFI.
Y-site administration:
Drug to Drug IV Compatibility: Amikacin, aztreonam, bumetanide, calcium gluconate, dexamethasone, fluconazole, furosemide, heparin, hydrocortisone, hydromorphone, imipenem, insulin regular, levofloxacin, linezolid, lorazepam, methylprednisolone, metronidazole, milrinone, piperacillin/tazobactam, ranitidine.
Drug to Drug IV Incompatibility: Acyclovir, amphotericin B, amphotericin B cholesteryl sulphate complex, chlordiazepoxide, chlorpromazine, cimetidine, ciprofloxacin, cisplatin, dacarbazine, daunorubicin, diazepam, diltiazem, diphenhydramine, dobutamine, dopamine, doxorubicin, droperidol, enalapril, etoposide, etoposide phosphate, famotidine, filgrastim, floxuridine, ganciclovir, haloperidol, hydroxyzine, idarubicin, ifosfamide, lansoprazole, magnesium sulphate, mechlorethamine, meperidine, metoclopramide, midazolam, mitomycin, mitoxantrone, morphine, nalbuphine, ofloxacin, ondansetron, pantoprazole, plicamycin, prochlorperazine edisylate, promethazine, streptozocin, vancomycin, vinblastin, vincristine.
When admixed: Incompatible with aminophylline, gentamicin, netilmicin, tobramycin, vancomycin.
Stability: In the dry state store at 2°C-25°C. Protect from light. Reconstituted solution may be stored up to 24 hours at controlled room temperature 20°C -25°C, or 7 days in a refrigerator, 2°C-8°C.

what are the adverse effects of Ucefore Injection 1 gm 1 Vial

Pseudomembranous colitis; superinfection; neutropenia; injection site reaction (IV); GI upset; headache, rash.

What is the dose of Ucefore Injection 1 gm 1 Vial

Lower Respiratory Infection: Adults: Moderate-Severe: 1-2 gm IV every 12 hr for 10 days. Children: 2 mth-16 yr: lt; 40 kg: 50 mg/kg IV every 12 hr. Max: Do not exceed adult dose.
Urinary Tract Infection: Adults: Mild-Moderate: 0.5-1 gm IM/IV every 12 hr for 7-10 days. Severe: 2 gm IV every 12 hr for 10 days. Children: 2 mth-16 yr: lt;40 kg: 50 mg/kg IV every 12 hr. Max: Do not exceed adult dose.
Skin Infection: Adults: Moderate-Severe: 2 gm IV every 12 hr for 10 days. Children: 2 mth-16 yr: lt;40 kg: 50 mg/kg IV every 12 hr. Max: Do not exceed adult dose.

One of the following licensed pharmacy from the nearest location will deliver Ucefore Injection 1 gm 1 Vial. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts the your request based on valid prescription and availability.

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