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Information on this page was last modified on : 2020/06/29 1:58:24 PM

Unexolone tablet 10 mg 500's

Unexolone tablet contains Metoclopramide HCl | belongs to Antidopaminergic

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How it works

It works by increasing the movement of food in the stomach and the intestine.

Side effects

Major & minor side effects for Unexolone tablet 10 mg 500’s

  • Dizziness severea
  • Abdominal pain severea
  • Convulsions severea
  • Headache severea
  • Skin rash severea
  • Irregular heartbeat severea
  • Diarrhea
  • Restlessness
  • Breast pain and tenderness
  • Increased flow of breast milk

Uses of Unexolone tablet 10 mg 500’s

What is it prescribed for?

  • Chemotherapy induced nausea and vomiting

    Unexolone tablet 10 mg 500’s is used to treat nausea and vomiting associated with the use of chemotherapy medicines for the treatment of cancer.

  • Gastroparesis

    Unexolone tablet 10 mg 500’s is used in the treatment of Gastroparesis since it increases the gastric emptying and prevents nausea and vomiting.

  • Gastroesophageal Reflux Disease

    Unexolone tablet 10 mg 500’s is used in the treatment of Gastroesophageal Reflux Disease since it increases the gastric emptying and reduces the reflux of gastric contents.

Concerns

Frequently asked questions

  • Onset of action

    The effect of this medicine can be observed in 30 to 60 minutes after an oral dose, 1 to 3 minutes after an intravenous dose, and 10 to 15 minutes after an intramuscular dose.

  • Duration of Effect

    The effect of this medicine lasts for an average duration of 1 to 2 hours.

  • Safe with Alchohol?

    Alcohol should not be consumed while receiving this medicine as it may increase the risk of dizziness and lightheadedness. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and Unexolone tablet 10 mg 500’s are used together.

  • Is it habit forming?

    No habit forming tendency has been reported.

  • Usage in pregnancy?

    This medicine is recommended for use in pregnant women only if necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

  • Usage while breast-feeding?

    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

When not to use?

  • Allergy

    This medicine is not recommended for use in patients with a known allergy to Unexolone tablet 10 mg 500’s .

  • Gastrointestinal disorders

    This medicine is not recommended for use in patients with gastrointestinal disorders like gastrointestinal hemorrhage, mechanical obstruction, and gastrointestinal perforation.

  • Seizure disorder

    This medicine is not recommended for use in patients with a known history of seizures.

  • Pheochromocytoma

    This medicine is not recommended for use in patients with conditions like pheochromocytoma due to an increase in the risk of hypertensive crisis (very severe increase in the blood pressure).

Warnings

Warnings for special population
  • Pregnancy

    This medicine is recommended for use in pregnant women only if necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

  • Breast-feeding

    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Warnings

Warnings for special population
  • Neuroleptic Malignant Syndrome (NMS)

    Unexolone tablet 10 mg 500’s is known to cause Neuroleptic Malignant Syndrome which is characterized by hyperthermia (fever), muscle rigidity, and altered consciousness. Report to the doctor immediately if these symptoms appear. Discontinue Unexolone tablet 10 mg 500’s treatment if the symptoms persist.

  • Depression

    Unexolone tablet 10 mg 500’s may cause depression in patients with or without the prior history of depression. Any symptoms of change in behavior or suicidal thoughts should be informed to the doctor on priority. Discontinue the treatment if the symptoms worsen.

Dosage

  • Missed Dose

    The missed dose can be taken as soon as you remember. However, the missed dose should be skipped if it is almost the time for the next dose.

  • Overdose

    Seek emergency medical treatment or contact the doctor in case of an overdose.

Interactions

Interaction with Medicines
  • Phenytoin moderate
  • Phenytoin moderate
  • Chlorpromazine severe
Disease interactions
  • severe

    Unexolone tablet 10 mg 500’s is not recommended for use in patients with gastrointestinal disorders like mechanical bowel obstruction, bowel perforation, or gastrointestinal hemorrhage. An alternative treatment option should be considered based on the clinical condition.

  • moderate

    Unexolone tablet 10 mg 500’s should be used with caution in patients with Parkinson's disease due to an increase in the risk of parkinsonian-like symptoms such as akinesia, bradykinesia, tremors, pill-rolling motion, and postural abnormalities. These symptoms will usually appear within the first 6 months of the treatment and subside within 2 to 3 months after discontinuation of the treatment.

Lab interactions

General Instructions

Take Unexolone tablet 10 mg 500’s as advised by the doctor. Do not take this medicine if you have gastrointestinal disorders like mechanical bowel obstruction, bowel perforation, or gastrointestinal hemorrhage. Monitoring of blood pressure and symptoms like involuntary movements of the tongue, lips, face, and trunk is necessary while consuming this medicine.

Other details

  • To be taken before food
  • To be taken as instructed by doctor
  • May cause sleepiness

References

How to use Unexolone tablet 10 mg 500’s

Injection solution may be given IM, direct IV push, short infusion (15-30 min), or continuous infusion; lower doses (=10 mg) of metoclopramide can be given IV push undiluted over 1-2 min; higher doses to be given IVPB over at least 15 min.
Reconstitution: For IV use, doses lt;10 mg do not need dilution. For doses gt;10 mg, dilute in 50 mL 0.9%NS, 0.45% NS, D5W, or lactated Ringer’s solution.
Compatibility: Stable in D5 1/2 NS, LR, NS, mannitol 20%.
Stability: Store at 20°C-25°C (68°F-77°F). Store vials in carton until use. Do not store open single-dose vials for later use, as they contain no preservative. This product is light sensitive. It should be inspected before use and discarded if either colour or particulate is observed. Dilutions may be stored unprotected from light under normal light conditions up to 24 hours after preparation.

what are the adverse effects of Unexolone tablet 10 mg 500’s

Extrapyramidal reactions, neuroleptic malignant syndrome. Raised serum prolactin leading to galactorrhoea, irregular periods and gynaecomastia. Drowsiness, diarrhoea, rash, dizziness, tremor, agitation.

What is the dose of Unexolone tablet 10 mg 500’s

Adults: 20 yr and over: 10 mg three times daily orally, IM or IV. Usual max 0.5 mg/kg body-wt daily.
Children: Second-line option for treatment of established postoperative nausea and vomiting and prevention of delayed chemotherapy-induced nausea and vomiting: ORAL or IM injection, or IV injection over at least 3 minutes: 1-18 yr, 100-150 mcg/kg up to 3 times daily.

One of the following licensed pharmacy from the nearest location will deliver Unexolone tablet 10 mg 500’s. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts the your request based on valid prescription and availability.

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