Unitrexate tablet 10 mg 100’s

 1,466.00

Manufactured by:
Active Pharmaceutical Ingredient:
Drug Strength: 10 mg
Drug Form : Tablet
Pack Size : 100s
Does this requires a prescription ?Yes

Unitrexate tablet contains Methotrexate | belongs to Folic acid antagonist

SKU: pg_23481_32484 Categories: ,

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    How it works

    Unitrexate tablet 10 mg 100’s works by interfering the DNA synthesis and stops the growth of the cells.

    Side effects

    Major & minor side effects for Unitrexate tablet 10 mg 100’s

    • Diarrhea severe
    • Joint pain severe
    • Abdominal pain severe
    • Swelling of feet or lower legs severe
    • Dizziness severe
    • Fever with chills severe
    • Unusual bleeding severe
    • Blurred vision severe
    • Temporary Hair Loss
    • Loss of appetite
    • Nausea or Vomiting
    • Pale skin
    • Skin rash

    Uses of Unitrexate tablet 10 mg 100’s

    What is it prescribed for?

    • Acute Lymphoblastic Leukemia

      Unitrexate tablet 10 mg 100’s is used in the treatment of cancer of the bone marrow that affects the production of white blood cells.

    • Choriocarcinoma

      Unitrexate tablet 10 mg 100’s is used in the treatment of cancer of the women's uterus.

    • Meningeal Leukemia

      Unitrexate tablet 10 mg 100’s is used in the treatment of cancer meningitis which is a thin layer that protects the brain and spinal cord.

    • Breast cancer

      Unitrexate tablet 10 mg 100’s is used with other medications in the treatment of breast cancer.

    • Rheumatoid Arthritis

      Unitrexate tablet 10 mg 100’s is used to relieve the symptoms of inflammation in rheumatoid arthritis.

    • Psoriasis

      Unitrexate tablet 10 mg 100’s is used in the treatment of psoriasis which is an autoimmune skin disease.

    Concerns

    Frequently asked questions

    • Onset of action

      The effect of this medicine can be observed in 1 to 2 hours after an oral dose and 30 to 60 minutes after an intramuscular injection.

    • Duration of Effect

      The effect of this medicine lasts for an average duration of 9 to 30 hours at a low dose and 24 to 45 hours at a high dose.

    • Safe with Alchohol?

      Consumption of alcohol is not recommended due to the risk of liver injury. Close monitoring of liver enzymes is necessary. Seek immediate medical treatment if any symptoms like lethargy, yellow colored eyes, and skin, abdominal pain appear.

    • Is it habit forming?

      No habit forming tendencies were reported.

    • Usage in pregnancy?

      This medicine is not recommended for pregnant women.

    • Usage while breast-feeding?

      This medicine is not recommended in breastfeeding women.

    When not to use?

    • Allergy

      Not recommended in patients with known allergy to Unitrexate tablet 10 mg 100’s .

    • Pregnancy

      Not recommended for pregnant women due to the risk of birth defects.

    • Liver disease

      Not recommended in patients with the existing liver disease.

    • Blood disorder

      Not recommended in patients with existing blood diseases.

    Warnings

    Warnings for special population
    • Pregnancy

      This medicine is not recommended for pregnant women.

    • Breast-feeding

      This medicine is not recommended in breastfeeding women.

    General Warnings
    • Liver injury

      This medicine is not recommended in the patients with the liver injury. The concentration of this medicine may increase in these patients. The baseline of the liver function tests should be obtained before starting the treatment.

    • Kidney injury

      This medicine is not recommended in the patients with the kidney injury. It may cause kidney injury at higher doses. The dose of this medicine should be adjusted based on the CrCl.

    • Lung toxicity

      This medicine may cause severe lung injuries like pulmonary fibrosis, pulmonary interstitial infiltrates. Any symptoms of breathing difficulty and signs of lung impairment should be informed to the doctor. The treatment should be discontinued if any symptoms appear.

    • Blood cell count

      This medicine may lower the white blood cell count (neutrophils) and platelets. Close monitoring of blood cell count is necessary. The baseline of the blood cell count should be obtained before initiation of the treatment. Do not start the treatment if the counts are less.

    • Skin reactions

      The medicine may cause severe skin reactions stevens-johnson syndrome, skin necrosis, and skin ulceration. Inform the doctor if any symptoms appear. The treatment should be discontinued.

    • Gastrointestinal injury

      This medicine is not recommended for use in patients with gastrointestinal disorders like diarrhea and ulcerative stomatitis. Inform the doctor if you have any gastrointestinal disorders before initiation of the therapy.

    • Infections

      The chances of occurring infections are more in the patients receiving this medicine. Hold the chemotherapy and start with the broad-spectrum antibiotics if there are any signs and symptoms of fever. Close monitoring of the body temperature and the blood cell count is necessary.

    Dosage

    • Missed Dose

      It is advised not to miss any dose. If you missed any dose, you should contact your doctor immediately.

    • Overdose

      Seek emergency medical treatment or contact the doctor in case of an overdose.

    Interactions

    Interaction with Medicines
    • Azole antifungal agents moderate
    • Atorvastatin moderate
    • Live vaccines severe
    • Proton pump inhibitors severe
    Disease interactions
    • severe

      Unitrexate tablet 10 mg 100’s is not recommended for the treatment of psoriasis and rheumatoid arthritis in patients with liver disease. The baseline of the liver enzymes should be obtained before starting the therapy. The treatment should be discontinued if liver enzymes are elevated.

    General Instructions

    Take Unitrexate tablet 10 mg 100’s as instructed by your doctor. Do not take in larger amounts than advised. Do not miss any scheduled dose. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine without consulting your doctor.

    Other details

    • Can be taken with or without food, as advised by your doctor
    • To be taken as instructed by doctor
    • May cause sleepiness

    References

    Additional Information>

    How to use Unitrexate tablet 10 mg 100’s

    It may be administered IM, IV or IT. IV administration may be slow push, short bolus inf or 24-42 hour continuous inf. Dilute powder with D5W or NS to a conc. of = 25 mg/mL (20 mg and 50 mg vials)and 50 mg/mL (1 gm vial). Intrathecal solutions may be reconstituted to 2.5 to 5 mg/mL with NS, D5W, LR or Elliott’s B solution. Use preservative free preparations for IT or high dose administration.
    Stability: Store at 20°C-25°C (68°F-77°F); excursions are permitted to 15°C -30°C (59°F-86°F). Protect from light.

    what are the adverse effects of Unitrexate tablet 10 mg 100’s?

    Bone marrow depression, GI upset, hepatotoxicity, skin reactions, opportunistic infections, urino-genital disorders, decreased fertility and pulmonary disease and CNS disturbances.

    What happens if I miss a dose of Unitrexate tablet 10 mg 100’s?

    Adults: Antineoplastic: Burkitt’s Lymphoma: Stages I-II: Orally: 10-25 mg/day for 4-8 day for several courses; separate by 7-10 day rest period.
    Lymphosarcomas: Stage III: Orally: 0.625-2.5 mg/kg/day.
    Leukaemia: Induction: 3.3 mg/m² with prednisone every day. Remission Maintenance: 15 mg/m² Orally/IM twice wkly or 2.5 mg/kg IV every 14 day.
    Mycosis fungoides: 5-50 mg every wk. If poor response, give 15-37.5 mg twice wkly.
    Osteosarcoma: Initial: 12 gm/m² IV, increase to 15 gm/m² if peak levels of 1000 micro-molar not reached at end of infusion.
    Choriocarcinoma/trophoblastic diseases: Orally/IM: 15-30 mg every day x 5 day, rest gt;1 wk & repeat 3-5 times.
    Rheumatoid arthritis: Initial: 7.5 mg once wkly or 2.5 mg every 12 hr x 3 doses once wkly. Max: 20 mg/wk. Reduce to lowest effective dose.
    Psoriasis: Usual: 10-25 mg/wk Orally/IV/IM until adequate response achieved or use 2.5 mg every 12 hr x 3 doses. Titrate: May increase gradually. Max: 30 mg/wk.
    Children: Meningeal leukaemias: Intrathecal: Dilute preservative free Methotrexate to 1 mg/mL. Dose every 2-5 day. gt;3 yr: 12 mg. 2 yr: 10 mg. 1 yr: 8 mg. lt;1 yr: 6 mg.
    Juvenile rheumatoid arthritis: Children 2-16 yr: 10 mg/m² once wkly. Adjust dose to optimal response.

    One of the following licensed pharmacy from the nearest location will deliver Unitrexate tablet 10 mg 100’s. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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