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Information on this page was last modified on : 2020/06/26 11:00:18 AM

Vorif tablet 50 mg 10's

Belongs to Category

Vorif tablet contains Voriconazole | belongs to Triazole antifungal

Alternate brands of Vorif tablet 50 mg 10’s

Brand Name Price Savings
Vorix Injection 200mg (voriconazole)  4,000.00 You will pay -3600 more
Vorif tablet 200 mg 10’s  3,000.00 You will pay -2600 more
Voricon tablet 200 mg 10’s  1,100.00 You will pay -700 more
List of alternate brands

How it works

Vorif tablet 50 mg 10’s works by slowing the growth of the fungi that cause infection.

Side effects

Major & minor side effects for Vorif tablet 50 mg 10’s

  • Increased sensitivity of the eyes to sunlight severe
  • Skin rash severe
  • Abdominal pain severe
  • Convulsions severe
  • Dizziness severe
  • Increased thirst severe
  • Yellow colored eyes or skin severe
  • Muscle pain severe
  • Irritability severe
  • Severe sunburn severe
  • Diarrhea
  • Headache

Uses of Vorif tablet 50 mg 10’s

What is it prescribed for?

  • Invasive Aspergillosis

    This medicine is used in the treatment of infections in the lungs or immune system caused by Aspergillus strain of fungus.

  • Esophageal Candidiasis

    This medicine is used in the treatment of infections in the throat caused by Candida strain of fungus.

  • Candidemia

    This medicine is used in the treatment of infections of the blood caused by Candida strain of fungus.

  • Fungal Pneumonia

    This medicine is used in the treatment of infections that affects the lungs caused by Histoplasma capsulatum and Candida strains of fungi.

  • Fusariosis

    This medicine is used in the treatment of infections that affect immunocompromised patients caused by fusarium strain of fungus.

Concerns

Frequently asked questions

  • Onset of action

    The peak effect of this medicine can be observed in 1 to 2 hours.

  • Duration of Effect

    The effect of this medicine lasts for an average duration of 6 hours.

  • Safe with Alchohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    No habit forming tendencies were reported.

  • Usage in pregnancy?

    This medicine is not recommended for pregnant women unless clearly needed. Consult your doctor regarding potential benefits and risks before taking this medicine.

  • Usage while breast-feeding?

    Sufficient information is not available on whether this medicine is excreted through breast milk. Stop breastfeeding if it's necessary to take this medicine. Consult your doctor regarding potential benefits and risks before taking this medicine.

When not to use?

  • Allergy

    This medicine is not recommended for use if you have a known allergy to this medicine.

  • QT Interval prolonging drugs

    This medicine is not recommended for co-administration with drugs that are known to cause specific changes in heart rhythm.

Warnings

Warnings for special population
  • Pregnancy

    This medicine is not recommended for pregnant women unless clearly needed. Consult your doctor regarding potential benefits and risks before taking this medicine.

  • Breast-feeding

    Sufficient information is not available on whether this medicine is excreted through breast milk. Stop breastfeeding if it's necessary to take this medicine. Consult your doctor regarding potential benefits and risks before taking this medicine.

General Warnings
  • Liver injury

    This medicine may increase the liver enzyme levels and can cause hepatitis and jaundice. Close monitoring of liver function (through tests) is necessary at the time of initiation of the treatment. Discontinue the medicine if symptoms worsen.

  • Visual Disturbances

    This medicine may cause visual disturbances like optic neuritis and papilledema. Close monitoring of visual function is necessary if treatment continues beyond 28 days.

  • Arrhythmia and QT Prolongation

    This medicine may cause Arrhythmia and QT Prolongation especially in the patients with existing heart disease. Close monitoring of heart function is necessary. Do not use medicines that can increase the risk of arrhythmia.

  • Impaired kidney function

    Use of intravenous Vorif tablet 50 mg 10’s is not recommended in the patients with moderate to severe kidney injury (creatinine clearance level < 50 mL/min) due to the risk of accumulation. Oral dosage forms may be considered after assessing benefits and risks.

  • Monitoring pancreas function

    This medicine may increase the risk of pancreatitis in the patients who have undergone recent chemotherapy or hematopoietic stem cell transplantation. Close monitoring of the functioning of the pancreas is necessary.

  • Skin reactions

    This medicine may cause serious skin reactions like Stevens-Johnson syndrome or photosensitivity skin reaction. Close monitoring of skin reactions is necessary. Avoid exposure to sunlight by wearing protective clothing and using sunscreen with high sun protection factor (SPF).

  • Pediatric population

    The safety and effectiveness of Vorif tablet 50 mg 10’s is not established in patients who are less than 2 years of age.

Dosage

  • Missed Dose

    The missed dose can be taken as soon as you remember. If it is time for the next dosage then the missed dose can be skipped.

  • Overdose

    Inform your doctor immediately if you are experiencing symptoms of overdose.

Interactions

Interaction with Medicines
  • Alprazolam severe
  • Cisapride severe
  • Clopidogrel severe
  • Warfarin moderate
  • Atorvastatin severe
Disease interactions
  • severe

    This medicine should be administered with caution if you are suffering from impaired liver functioning. Suitable dosage adjustment and safety monitoring is necessary in such cases.

  • moderate

    This medicine should be administered with caution if you have any pre-existing heart conditions. Suitable dosage adjustment and safety monitoring is recommended in such cases.

  • moderate

    Suitable adjustment in dosage is required based on the extent of kidney impairment. If the patient is on hemodialysis then the level of this medicine in the blood should be monitored after each session and then the adjusted dose should be administered.

Food interactions
  • Take This medicine at least 1 hour before or after food for better absorption.

General Instructions

This medicine should be taken following all the instructions that are given by your doctor. To ensure complete recovery and no relapse, the full course of treatment should be followed. It is more effective if taken at the same time on all days. Any instance of side effects should be reported to the doctor immediately.

Other details

  • To be taken on an empty stomach
  • To be taken as instructed by doctor
  • May cause sleepiness

References

Additional Information:

How to use Vorif tablet 50 mg 10’s

Reconstitute with 19 mL of SWFI and shake well to yield 20 mL of voriconazole 10 mg/mL solution. Administered by IV infusion in a compatible infusion solution at a concentration between 0.5 and 5 mg/mL over 1 to 2 hours at a max rate of 3 mg/kg/hour.
Compatibility: Dextrose 5%, NaCl 0.9%.
Stability: Reconstituted stable for 24 hours under refrigeration, use immediately after reconstitution because no antimicrobial preservative is present. Single use only and any remaining drug should be discarded.

what are the adverse effects of Vorif tablet 50 mg 10’s?

Headache, paresthesia, somnolence, GI upset, rash, visual disturbances, pyrexia, gastroenteritis, sinusitis, depression, hallucination, anxiety, tremors, agitation, chills, asthaenia, back and chest pain, inj or inf site reactions, acute respiratory distress syndrome, flu-like symptoms, hypotension, thrombophlebitis, phlebitis, raised LFTs and creatinine, jaundice, cheilitis, pruritus, alopecia, dermatitis, blood dyscrasia, purpura, erythema, hypokalaemia, hypoglycaemia, dizziness, confusion, acute renal failure, hematuria, peripheral pulmonary and facial oedema.

What happens if I miss a dose of Vorif tablet 50 mg 10’s?

INFUSION: Adults: Loading dose: For first 24 hr, 6 mg/kg by IV infusion every 12 hr. Maintenance dose: 4 mg/kg by IV infusion twice daily. If not tolerated it may be reduced to 3 mg/kg twice daily. Max infusion rate: 3 mg/kg/hr over 1-3 hr. Max treatment duration, 6 mth.
Children: Under 2 yr: Not recommended; 2-12 yr: or 12-14 yr and less than 50 kg, Loading dose: For first hrs, 9 mg/kg by IV inf every 12 hrs. Maint; 8 mg/kg by IV inf twice daily. 12-14 yr and =50 kg, as adults. If response inadequate, maintenance dose may be increased in 1 mg/kg steps. If not tolerated, it may be reduced in 1 mg/kg steps. Max inf. Rate 3 mg/kg/hr over 1-3 hr.
ORAL: Adults: For first 24 hr: 400 mg every 12 hr (gt;40 kg) or 200 mg every 12 hr (lt;40 kg), Maint: 200 mg twice daily (gt; than 40 kg) or 100 mg twice daily (lt;40 kg). If response inadequate it may be increased to 300 mg twice daily (gt; 40 kg) or 150 mg twice daily (lt;40 kg). A tablet should be taken 1 hr before or 1 hr after food.
Children: Under 2 yr: Not recommended; 2-12 yr or 12-14 yr and body wt lt; 50 kg: Use infusion until significant improvement then 9 mg/kg twice daily. (preferred as susp lt;12 yr). Titrate if necessary in 1 mg/kg increments (50 mg increments if initial dose was 350 mg); max 350 mg twice daily; 12-14 yr and body wt lt; 50 kg, same as adults. Tab should be taken 1 hr before or 1 hr after food; susp should be taken 1 hr before or 2 hr after food.

One of the following licensed pharmacy from the nearest location will deliver Vorif tablet 50 mg 10’s. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

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