vyndaqel 61mg (tadamidis) soft capusle

How it Works

Vyndaqel, also known as tafamidis, is a medication used in the treatment of transthyretin amyloidosis (ATTR) in adults with symptomatic polyneuropathy. ATTR is a rare, progressive disease characterized by the abnormal accumulation of misfolded transthyretin protein, leading to tissue damage and organ dysfunction. Tafamidis works by stabilizing the transthyretin protein, thereby preventing its misfolding and aggregation into amyloid fibrils. By stabilizing the transthyretin tetramer, tafamidis helps preserve organ function and slow the progression of the disease.

Side Effects

• Peripheral edema (swelling of extremities)
• Urinary tract infections
• Diarrhea
• Dizziness
• Upper respiratory tract infections
• Orthostatic hypotension (low blood pressure upon standing)
• Decreased platelet count
• Upper abdominal pain
• Headache
• Vertigo

Indications

• Transthyretin amyloidosis (ATTR) in adults with symptomatic polyneuropathy

Contraindications

• Hypersensitivity to tafamidis or any of its excipients
• Severe renal impairment (creatinine clearance less than 30 mL/min)
• Pregnancy and breastfeeding (use only if clearly needed and benefits outweigh the risks)

Price Comparison in Different Countries

Top 5 Global Brands

1. Vyndaqel (Pfizer)
2. Vyndamax (Pfizer)
3. Inotersen (Ionis Pharmaceuticals)
4. Patisiran (Alnylam Pharmaceuticals)
5. AG10 (Eidos Therapeutics)