Content Details
Information on this page was last modified on : 2024/06/10 7:46:49 PM

ZOLGENSMA (onasemnogene abeparvovec-xioi)

Belongs to Category

How It Works

Zolgensma works by delivering a functional copy of the SMN gene into the patient’s cells using a viral vector called adeno-associated virus 9 (AAV9). This vector targets motor neuron cells and introduces the healthy SMN gene, which then produces the survival motor neuron (SMN) protein. This protein is essential for the maintenance and function of motor neurons, and its presence helps to improve muscle function and slow the progression of SMA.

Side Effects

  • Elevated liver enzymes
  • Nausea and vomiting
  • Decreased platelet count (thrombocytopenia)
  • Fever
  • Decreased appetite
  • Elevated cardiac troponin-I


  • Treatment of spinal muscular atrophy (SMA) in pediatric patients under the age of 2 with bi-allelic mutations in the SMN1 gene


  • Hypersensitivity to any of the components of Zolgensma
  • Patients with advanced liver disease
  • Severe pre-existing thrombocytopenia

Price Comparison in Different Countries

Country Price Reference
Pakistan Approximately PKR 250,000,000 Dawaai Pakistan
United States USD 2,125,000 GoodRx
United Kingdom GBP 1,795,000 NHS UK
Canada CAD 2,850,000 Health Canada
Australia AUD 2,900,000 PBS Australia

Top 5 Global Brands

  1. Novartis
  2. Pfizer
  3. Roche
  4. Sanofi
  5. GlaxoSmithKline (GSK)


Zolgensma (Onasemnogene Abeparvovec-xioi) represents a significant advancement in the treatment of spinal muscular atrophy (SMA). By providing a functional copy of the SMN gene, Zolgensma helps improve motor neuron function and slow the progression of SMA in young children. Despite its high cost, Zolgensma offers hope for better quality of life for patients with SMA. The cost of Zolgensma varies widely across different countries, reflecting disparities in healthcare pricing and accessibility. Patients and families should consult with their healthcare providers and explore financial assistance programs to access this life-changing treatment.


Additional Information:

One of the following licensed pharmacy from the nearest location will deliver ZOLGENSMA (onasemnogene abeparvovec-xioi). The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts your request based on valid prescription and availability.

Want to share this information?
Something doesn't feel right ?

Questions and Answers

There are no questions yet. Be the first to ask a question about this product.

Only registered users are eligible to enter questions


There are no reviews yet.

Be the first to review “ZOLGENSMA (onasemnogene abeparvovec-xioi)”
Shopping Cart