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Zyncillin Injection 500 mg 10 Vial

, This drug requires a valid prescription from PMDC registered health practitioner.
Manufactured by
Contains

Zyncillin Injection contains Ampicillin | belongs to Broad-spectrum penicillin

Product SKUpg_25426_35425
Drug Strength
Pack size

Side effects

Major & minor side effects for Zyncillin Injection 500 mg 10 Vial

  • Diarrhea severe
  • Skin rash severe
  • Pain at the injection site
  • Fever with chills
  • Seizures

Uses of Zyncillin Injection 500 mg 10 Vial

What is it prescribed for?

  • Bacterial Meningitis

    Zyncillin Injection 500 mg 10 Vial is used in the treatment of meningitis, which is an inflammation of the protective membranes that surround the brain and spinal cord, caused by Streptococcus pneumoniae and Neisseria meningitidis.

  • Respiratory Tract Infection

    Zyncillin Injection 500 mg 10 Vial is used in the treatment of respiratory tract infections like pneumonia and brochitis, caused by Streptococcus pneumoniae and Staphylococcus aureus.

  • Endocarditis

    Zyncillin Injection 500 mg 10 Vial is used in the treatment of Endocarditis which is an inflammation of inner layer of heart caused by Streptococcus species: Staphylococci, and Enterococci.

  • Bacterial Septicemia

    Zyncillin Injection 500 mg 10 Vial is used in the treatment of Septicemia which is an infection of the blood caused by Staphylococci and Streptococcus pyogenes.

  • Urinary Tract Infection

    Zyncillin Injection 500 mg 10 Vial is used in the treatment of infections of the urinary tract caused by E.coli, Pseudomonas aeruginosa, Enterococci and Klebsiella pneumoniae.

Concerns

Frequently asked questions

  • Onset of action

    The peak effect of this medicine can be observed in 1 to 2 hours after an oral dose.

  • Duration of Effect

    The effect of this medicine lasts for an average duration of 3 to 6 hours.

  • Safe with Alchohol?

    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Is it habit forming?

    No habit forming tendencies have been reported.

  • Usage in pregnancy?

    This medicine is not known to cause any harm to the fetus. But the evidence is inadequate and it should be used only when necessary after consulting a doctor.

  • Usage while breast-feeding?

    This medicine is safe to use during breastfeeding. Any incidence of rashes on skin or diarrhea in the infant should be reported. It is advised to consult a doctor before taking this medicine.

When not to use?

  • Allergy

    Zyncillin Injection 500 mg 10 Vial is not recommended if a patient is highly allergic to Zyncillin Injection 500 mg 10 Vial or other antibiotics of Penicillins and Cephalosporins groups.

Warnings

Warnings for special population
  • Pregnancy

    This medicine is not known to cause any harm to the fetus. But the evidence is inadequate and it should be used only when necessary after consulting a doctor.

  • Breast-feeding

    This medicine is safe to use during breastfeeding. Any incidence of rashes on skin or diarrhea in the infant should be reported. It is advised to consult a doctor before taking this medicine.

Warnings

Warnings for special population
  • Allergic Reaction

    Avoid if you have a known allergy to Zyncillin Injection 500 mg 10 Vial or Beta-lactam Antibiotics like penicillins and cephalosporins. Seek immediate medical attention if the patient experiences any allergic symptoms like rash, itching, nausea or vomiting, swelling of lips, hands, and feet.

  • Drug-resistance

    Usage of Zyncillin Injection 500 mg 10 Vial without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that is drug resistant.

  • Clostridium difficile-associated Diarrhea

    Do not take if you experience severe diarrhea after receiving Zyncillin Injection 500 mg 10 Vial. This is because the antibiotic therapy will cause an imbalance in the normal microbial flora in the large intestine, which promotes the growth of bacteria called clostridium difficile.

  • Mononucleosis

    Zyncillin Injection 500 mg 10 Vial is likely to cause rashes and bumps on the skin if the patient is suffering from Mononucleosis. Usage of Zyncillin Injection 500 mg 10 Vial is not recommended in such cases.

Dosage

  • Missed Dose

    The missed dose should be taken as soon possible. It is advisable to skip the missed dose if it's already time for your next scheduled dose.

  • Overdose

    Seek emergency medical treatment or contact the doctor in case of overdose.

Interactions

Interaction with Medicines
  • Atenolol moderate
  • Chloroquine moderate
  • Doxycycline moderate
  • Methotrexate severe
  • Warfarin moderate
Disease interactions
  • severe

    The blood concentration of intravenous Zyncillin Injection 500 mg 10 Vial may increase in patients suffering from impaired kidney functioning. Suitable dose adjustments are to be made based on the severity of kidney function. Frequent monitoring of kidney function tests is necessary.

  • moderate

    Zyncillin Injection 500 mg 10 Vial should be discontinued if severe diarrhea occurs. Patients having a history of Colitis should be monitored closely.

Food interactions
  • The absorption of Zyncillin Injection 500 mg 10 Vial may decrease in the presence of food. For proper absorption of the medicine, it should be taken at least 1 hour before or 2 hours after meals.

General Instructions

Take Zyncillin Injection 500 mg 10 Vial 1 hour before or 2 hours after meals. Do not take in larger amounts than advised. Consult the doctor if you experience any undesirable effects. Do not stop taking Zyncillin Injection 500 mg 10 Vial before completion of course.

Other details

  • To be taken on an empty stomach
  • To be taken as instructed by doctor
  • May cause sleepiness

How it works

Zyncillin Injection 500 mg 10 Vial works by preventing the creation of a component necessary for bacterial cell wall formation. Thus stops the growth and multiplication of the microorganism.

References

How to use Zyncillin Injection 500 mg 10 Vial

May be administered by direct IV push over 3-5 min at a rate not to exceed 100 mg/min or IV intermittent infusion over 15-30 min at concentration not to exceed 30 mg/mL.
Reconstitution: IM: Add (depending on manufacturer) 1.2 mL of SWFI or bacteriostatic water for injection to each 125 mg vial, 1 mL of diluent to each 250 mg vial, 1.8 mL of diluent to each 500 mg vial, 3.5 mL of diluent to each 1 gm vial, or 6.8 mL of diluents to each 2 gm vial. Intermittent infusion: Add 5 mL of SWFI or bacteriostatic water for injection to each 125, 250, or 500 mg vial or 7.4 to 10 mL of diluent to each 1 or 2 gm vial.
Compatibility: Stable in D5W, NS. At Y-site administration, incompatible with amphotericin B cholesteryl sulphate complex, epinephrine, fluconazole, hydralazine, midazolam, ondansetron, sargramostim, verapamil, vinorelbine. In syringe, incompatible with erythromycin lactobionate, gentamicin, hydromorphone, kanamycin, lincomycin, metoclopramide. When admixed, incompatible with amikacin, chlorpromazine, dopamine, gentamicin, hydralazine, prochlorperazine.
Stability: Solutions for IM or direct IV should be used within 1 hour. Solutions for IV infusion will be inactivated by dextrose at room temperature. If dextrose containing solutions are to be used, the resultant solution will only be stable for 2 hours versus 8 hours in NS. Stability of parenteral admixture in NS at room temperature (25°C) is 8 hours and at refrigeration (4°C) is 2 days.

what are the adverse effects of Zyncillin Injection 500 mg 10 Vial

Hypersensitivity, GI upset, rash, transient rise in liver enzymes. Rarely pseudomembranous colitis.

What is the dose of Zyncillin Injection 500 mg 10 Vial

ORAL: Adults: 250 mg-1 gm every 6 hr. Children: 1 mth- 1 yr: 62.5 mg every 6 hr, the dose doubled in severe cases; 1-5 yr: 125 mg every 6 hr, the dose doubled in severe cases; 5-12 yr: 250 mg every 6 hr, the dose doubled in severe cases.
Urinary Tract Infection: Adults & Children over 10 yr, 500 mg every 8 hr, Children: Under 10 yr, half the adult dose.
Lower Respiratory Tract Infections: Adults & Children: gt; 20 kg: 250 mg every 6 hr. lt; 20 kg: 50 mg/kg/day divided as 6 hourly or 8 hourly dose.
Upper Respiratory Tract Infections: Adults & Children: gt; 20 kg: 250 mg every 6 hr. lt; 20 kg: 50 mg/kg/day divided as 6 hourly or 8 hourly dose.
INJECTION: Adults: 250-500 mg four to six times daily by IM or IV inj. Children: Half adult dose.
Meningitis: IV: Adults & Children: 150-200 mg/kg/day given every 3-4 hr.
Upper Respiratory Tract Infections: IM/IV: Adults & Children: gt; 40 kg: 250-500 mg every 8 hr. lt; 40 kg: 25-50 mg/kg every 6-8 hr.
Endocarditis (in combination with other antibiotic if necessary): By IV infusion: Adults: 2 gm every 6 hr, increased to 2 gm every 4 hr e.g. in enterococcal endocarditis or if ampicillin used alone.

One of the following licensed pharmacy from the nearest location will deliver Zyncillin Injection 500 mg 10 Vial. The details of the licensed pharmacy shall be shared once you request the drugs and the respective pharmacy accepts the your request based on valid prescription and availability.

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